MOUSE:MANBA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Manba (ECO:0000312 with MGI:MGI:88175) (synonyms: Bmn (ECO:0000303 with PMID:11892998^[1]))
Protein Name(s)	Beta-mannosidase Lysosomal beta A mannosidase Mannanase Mannase
External Links
UniProt	Q8K2I4
EMBL	AF306557 AK010623 AK142165 AK166340 AK170290 BC031409
CCDS	CCDS17857.1
RefSeq	NP_081564.3
UniGene	Mm.280536
ProteinModelPortal	Q8K2I4
SMR	Q8K2I4
STRING	10090.ENSMUSP00000029814
CAZy	GH2
PhosphoSite	Q8K2I4
MaxQB	Q8K2I4
PaxDb	Q8K2I4
PRIDE	Q8K2I4
Ensembl	ENSMUST00000029814
GeneID	110173
KEGG	mmu:110173
UCSC	uc008rlu.2
CTD	4126
MGI	MGI:88175
eggNOG	COG3250
GeneTree	ENSGT00390000001670
HOGENOM	HOG000186862
HOVERGEN	HBG052404
InParanoid	Q8K2I4
KO	K01192
OrthoDB	EOG7S7SD2
PhylomeDB	Q8K2I4
TreeFam	TF105723
UniPathway	UPA00280
NextBio	363463
PRO	PR:Q8K2I4
Proteomes	UP000000589
Bgee	Q8K2I4
CleanEx	MM_MANBA
ExpressionAtlas	Q8K2I4
Genevestigator	Q8K2I4
GO	GO:0005764 GO:0004567 GO:0006516 GO:0046355
Gene3D	2.60.120.260 2.60.40.320 3.20.20.80
InterPro	IPR008979 IPR013812 IPR006102 IPR006104 IPR006103 IPR013781 IPR017853 IPR028369
PANTHER	PTHR10066:SF12
Pfam	PF02836 PF02837
SUPFAM	SSF49303 SSF49785 SSF51445

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0004567	beta-mannosidase activity	PMID:16377659^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006516	glycoprotein catabolic process	PMID:16377659^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004567	beta-mannosidase activity	PMID:30552791^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046355	mannan catabolic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000007198 UniProtKB:Q5B7W2	P	Seeded From UniProt	complete
involved_in	GO:0006516	glycoprotein catabolic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88175 PANTHER:PTN000007198	P	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000007201 RGD:1305785	C	Seeded From UniProt	complete
enables	GO:0004567	beta-mannosidase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88175 PANTHER:PTN000007198 RGD:1305785 UniProtKB:Q5B7W2	F	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00462	C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	PMID:19710420^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006516	glycoprotein catabolic process	PMID:3447593^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305785	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:19710420^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005537	mannose binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305785	F	Seeded From UniProt	complete
enables	GO:0004567	beta-mannosidase activity	PMID:3447593^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004567	beta-mannosidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00462	F	Seeded From UniProt	complete
enables	GO:0004567	beta-mannosidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305785	F	Seeded From UniProt	complete
enables	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006103	F	Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006103	P	Seeded From UniProt	complete
enables	GO:0004567	beta-mannosidase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.2.1.25	F	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:3447593^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016798	hydrolase activity, acting on glycosyl bonds	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0326	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0326	P	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Beccari, T et al. (2001) Mouse beta-mannosidase: cDNA cloning, expression, and chromosomal localization. Biosci. Rep. 21 315-23 PubMed GONUTS page
↑ ^2.0 ^2.1 Zhu, M et al. (2006) Beta-mannosidosis mice: a model for the human lysosomal storage disease. Hum. Mol. Genet. 15 493-500 PubMed GONUTS page
↑ Gytz, H et al. (2019) The structure of mammalian β-mannosidase provides insight into β-mannosidosis and nystagmus. FEBS J. 286 1319-1331 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Boonen, M et al. (2009) Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity. Mol. Biol. Cell 20 4381-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Lundin, LG (1987) A gene (Bmn) controlling beta-mannosidase activity in the mouse is located in the distal part of chromosome 3. Biochem. Genet. 25 603-10 PubMed GONUTS page

[PMID:11892998-1] Beccari, T et al. (2001) Mouse beta-mannosidase: cDNA cloning, expression, and chromosomal localization. Biosci. Rep. 21 315-23 PubMed GONUTS page

[PMID:16377659-2] 2.0 ^2.1 Zhu, M et al. (2006) Beta-mannosidosis mice: a model for the human lysosomal storage disease. Hum. Mol. Genet. 15 493-500 PubMed GONUTS page

[PMID:30552791-3] Gytz, H et al. (2019) The structure of mammalian β-mannosidase provides insight into β-mannosidosis and nystagmus. FEBS J. 286 1319-1331 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19710420-5] 5.0 ^5.1 Boonen, M et al. (2009) Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity. Mol. Biol. Cell 20 4381-9 PubMed GONUTS page

[PMID:3447593-6] 6.0 ^6.1 ^6.2 Lundin, LG (1987) A gene (Bmn) controlling beta-mannosidase activity in the mouse is located in the distal part of chromosome 3. Biochem. Genet. 25 603-10 PubMed GONUTS page

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MOUSE:MANBA

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