PMID:11892998

Citation	Beccari, T, Bibi, L, Stinchi, S, Stirling, JL and Orlacchio, A (2001) Mouse beta-mannosidase: cDNA cloning, expression, and chromosomal localization. Biosci. Rep. 21:315-23
Abstract	Beta-mannosidase is an exoglycosidase involved in the degradation of N-linked oligosaccharides moieties of glycoproteins. Lack of beta-mannosidase activity leads to the lysosomal disorder beta-mannosidosis (MIM 248510). We have isolated and sequenced the gene encoding the mouse beta-mannosidase. Comparison of the deduced amino acid sequence of mouse, human, bovine, and goat beta-mannosidase showed 64%, identity, reflecting a high degree of evolutionary conservation. Analysis of a multiple tissue northern blotting revealed a major transcript of about 3.7 kb in all tissues examined. The northern analysis also demonstrates that there is differential tissue mRNA expression. The mouse beta-mannosidase gene (Bmn) was mapped to the distal end of Chromosome (Chr) 3, in a region that is homologous with a segment of human Chr 4 containing the orthologous human gene.
Links	PubMed
Keywords	Animals; Cattle; Cell Nucleus/enzymology; Cell Nucleus/genetics; Chromosome Mapping; Chromosomes/enzymology; Chromosomes/genetics; Chromosomes, Human, Pair 4/genetics; Cloning, Molecular; DNA, Complementary/analysis; DNA, Complementary/genetics; Eukaryotic Cells/enzymology; Evolution, Molecular; Gene Expression Regulation, Enzymologic/physiology; Goats/genetics; Humans; Lysosomal Storage Diseases/enzymology; Lysosomal Storage Diseases/genetics; Lysosomal Storage Diseases/physiopathology; Lysosomes/enzymology; Mannosidases/genetics; Mannosidases/isolation & purification; Mice; Molecular Sequence Data; Phylogeny; RNA, Messenger/metabolism; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Viscera/enzymology; beta-Mannosidase
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