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MOUSE:LUM
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Lum (synonyms: Lcn, Ldc) | |
| Protein Name(s) | Lumican
Keratan sulfate proteoglycan lumican KSPG lumican | |
| External Links | ||
| UniProt | P51885 | |
| EMBL | S79461 AF013262 AK014312 AK075737 AK164774 BC005550 | |
| CCDS | CCDS24142.1 | |
| RefSeq | NP_032550.2 | |
| UniGene | Mm.18888 | |
| ProteinModelPortal | P51885 | |
| SMR | P51885 | |
| IntAct | P51885 | |
| MINT | MINT-4100731 | |
| PhosphoSite | P51885 | |
| MaxQB | P51885 | |
| PaxDb | P51885 | |
| PRIDE | P51885 | |
| Ensembl | ENSMUST00000038160 | |
| GeneID | 17022 | |
| KEGG | mmu:17022 | |
| UCSC | uc007gwz.2 | |
| CTD | 4060 | |
| MGI | MGI:109347 | |
| eggNOG | COG4886 | |
| GeneTree | ENSGT00760000118969 | |
| HOGENOM | HOG000234447 | |
| HOVERGEN | HBG108061 | |
| InParanoid | P51885 | |
| KO | K08122 | |
| OMA | KKLHINY | |
| OrthoDB | EOG75F4DF | |
| PhylomeDB | P51885 | |
| TreeFam | TF334562 | |
| Reactome | REACT_198578 REACT_198960 REACT_216309 REACT_268667 REACT_269577 | |
| NextBio | 291134 | |
| PRO | PR:P51885 | |
| Proteomes | UP000000589 | |
| Bgee | P51885 | |
| CleanEx | MM_LUM | |
| Genevestigator | P51885 | |
| GO | GO:0005615 GO:0070062 GO:0005583 GO:0005578 GO:0051216 GO:0030199 GO:0045944 GO:0070848 GO:0014070 GO:0007601 | |
| InterPro | IPR001611 IPR003591 IPR000372 IPR027219 | |
| PANTHER | PTHR24371:SF54 | |
| Pfam | PF13855 PF01462 | |
| SMART | SM00369 SM00013 | |
| PROSITE | PS51450 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0032914 |
positive regulation of transforming growth factor beta1 production |
ECO:0000315 |
P |
Figure 3 shows that lumican deficient mice resulted in reduced TGF-β1 production |
complete | |||||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0000006) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030021 |
extracellular matrix structural constituent conferring compression resistance |
ECO:0007666 |
automatically integrated combinatorial computational and experimental evidence used in manual assertion |
F |
occurs_in:(UBERON:0000006) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0002048)|part_of:(UBERON:0001155) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030021 |
extracellular matrix structural constituent conferring compression resistance |
ECO:0007666 |
automatically integrated combinatorial computational and experimental evidence used in manual assertion |
F |
occurs_in:(UBERON:0002048)|occurs_in:(UBERON:0001155) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032914 |
positive regulation of transforming growth factor beta1 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
produced_by:(CL:0002548) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005518 |
collagen binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000689695 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(MGI:MGI:1202398) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:620984 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005583 |
fibrillar collagen trimer |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005518 |
collagen binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070848 |
response to growth factor |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51886 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051216 |
cartilage development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51886 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51886 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014070 |
response to organic cyclic compound |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51886 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005583 |
fibrillar collagen trimer |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51884 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005518 |
collagen binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P51884 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007601 |
visual perception |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030199 |
collagen fibril organization |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Li, LF et al. (2011) Lumican expression in diaphragm induced by mechanical ventilation. PLoS ONE 6 e24692 PubMed GONUTS page
- ↑ 2.0 2.1 Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page
- ↑ 3.0 3.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page
- ↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Carlson, EC et al. (2005) Keratocan, a cornea-specific keratan sulfate proteoglycan, is regulated by lumican. J. Biol. Chem. 280 25541-7 PubMed GONUTS page
- ↑ Raouf, A et al. (2002) Lumican is a major proteoglycan component of the bone matrix. Matrix Biol. 21 361-7 PubMed GONUTS page
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