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PMID:21931815
| Citation |
Li, LF, Chen, BX, Tsai, YH, Kao, WW, Yang, CT and Chu, PH (2011) Lumican expression in diaphragm induced by mechanical ventilation. PLoS ONE 6:e24692 |
|---|---|
| Abstract |
Diaphragmatic dysfunction found in the patients with acute lung injury required prolonged mechanical ventilation. Mechanical ventilation can induce production of inflammatory cytokines and excess deposition of extracellular matrix proteins via up-regulation of transforming growth factor (TGF)-β1. Lumican is known to participate in TGF-β1 signaling during wound healing. The mechanisms regulating interactions between mechanical ventilation and diaphragmatic injury are unclear. We hypothesized that diaphragmatic damage by short duration of mechanical stretch caused up-regulation of lumican that modulated TGF-β1 signaling. |
| Links |
PubMed PMC3170381 Online version:10.1371/journal.pone.0024692 |
| Keywords |
Actins/metabolism; Animals; Chondroitin Sulfate Proteoglycans/metabolism; Collagen/metabolism; Diaphragm/metabolism; Fibronectins/metabolism; Gene Expression Regulation; Keratan Sulfate/metabolism; Male; Mice; Mice, Inbred C57BL; Procollagen/metabolism; Respiration, Artificial/adverse effects; Tidal Volume/physiology; Transforming Growth Factor beta1/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0032914: positive regulation of transforming growth factor beta1 production |
ECO:0000315: |
P |
Figure 3 shows that lumican deficient mice resulted in reduced TGF-β1 production |
complete | ||||
|
involved_in |
GO:0032914: positive regulation of transforming growth factor beta1 production |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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