MOUSE:LN28A

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Lin28a (synonyms: Lin28, Tex17)
Protein Name(s)	Protein lin-28 homolog A Lin-28A Testis-expressed protein 17
External Links
UniProt	Q8K3Y3
EMBL	AF521097 BC068304
CCDS	CCDS18761.1
RefSeq	NP_665832.1
UniGene	Mm.302567
PDB	3TRZ 3TS0 3TS2
PDBsum	3TRZ 3TS0 3TS2
ProteinModelPortal	Q8K3Y3
SMR	Q8K3Y3
BioGrid	219943
DIP	DIP-48573N
IntAct	Q8K3Y3
STRING	10090.ENSMUSP00000050488
iPTMnet	Q8K3Y3
PhosphoSite	Q8K3Y3
MaxQB	Q8K3Y3
PaxDb	Q8K3Y3
PRIDE	Q8K3Y3
Ensembl	ENSMUST00000051674
GeneID	83557
KEGG	mmu:83557
UCSC	uc008vdw.1
CTD	79727
MGI	MGI:1890546
eggNOG	KOG3070 COG1278
GeneTree	ENSGT00840000129853
HOGENOM	HOG000047091
HOVERGEN	HBG081922
InParanoid	Q8K3Y3
KO	K18754
OMA	SGICKWF
OrthoDB	EOG72JWJ8
PhylomeDB	Q8K3Y3
TreeFam	TF316240
Reactome	[www.reactome.org/content/detail/R-MMU-452723 R-MMU-452723]
PRO	PR:Q8K3Y3
Proteomes	UP000000589
Bgee	Q8K3Y3
CleanEx	MM_LIN28
ExpressionAtlas	Q8K3Y3
Genevisible	Q8K3Y3
GO	GO:0005737 GO:0000932 GO:0010494 GO:0005730 GO:0005634 GO:0003677 GO:0035198 GO:0003729 GO:0003723 GO:0031369 GO:0008270 GO:0007281 GO:0010587 GO:0010586 GO:0045686 GO:1901724 GO:0045666 GO:0045727 GO:0031054 GO:0060964 GO:0006355 GO:0031123 GO:0048863 GO:0019827
Gene3D	2.40.50.140 4.10.60.10
InterPro	IPR011129 IPR002059 IPR012340 IPR001878
Pfam	PF00313 PF00098
PRINTS	PR00050
SMART	SM00357 SM00343
SUPFAM	SSF50249 SSF57756
PROSITE	PS50158

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0071076	RNA 3' uridylation	PMID:18951094^[1]	ECO:0000314			P		Fig. 3Aa and 3Ab: When comparing Lin28a mutant with wildtype, it can be seen that Lin28a does bind the miRNA species in question, pri-let-7a. With both pri-let-7a and Lin28a present, the sharp band at pre-let-7a produced with mutant lin28a seen on the northern blot is abrogated and instead a smear can be seen in its place. In Fig. 3Ba, these species of varying lengths (cloned from HEK293T cells ectopically expressing pri-let-7a-1 and Lin28a) are sequenced showing 3' uridylation of an average of 14 U nucleotides. Called Lin28a in paper	complete CACAO 12262
	GO:2000627	positive regulation of miRNA catabolic process	PMID:18951094^[1]	ECO:0000315			P		"Protein knockdown was carried out against human Lin28b in Huh7 cells and mouse Lin28a in mouse ESCs" Fig. S3 shows, with knocked down mouse Lin28a, there is a marked increase in accumulation of mature let7a species. Called mouse Lin28a in paper.	complete CACAO 12263
enables	GO:0035198	miRNA binding	PMID:28671666^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H9Z2	C		Seeded From UniProt	complete
part_of	GO:0005844	polysome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H9Z2	C		Seeded From UniProt	complete
enables	GO:1905538	polysome binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H9Z2	F		Seeded From UniProt	complete
involved_in	GO:2000767	positive regulation of cytoplasmic translation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H9Z2	P		Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:23102813^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	PMID:23102813^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:23102813^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035198	miRNA binding	PMID:26045559^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1990825	sequence-specific mRNA binding	PMID:26045559^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0002151	G-quadruplex RNA binding	PMID:26045559^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	PMID:21962509^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:21962509^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032008	positive regulation of TOR signaling	PMID:21962509^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	PMID:21962509^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001134)	Seeded From UniProt	complete
involved_in	GO:1901724	positive regulation of cell proliferation involved in kidney development	PMID:24732380^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048863	stem cell differentiation	PMID:18604195^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048863	stem cell differentiation	PMID:18292307^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	PMID:18604195^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	PMID:18292307^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010587	miRNA catabolic process	PMID:18604195^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010587	miRNA catabolic process	PMID:18292307^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H9Z2	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H9Z2	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:18604195^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:18292307^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H9Z2	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000767	positive regulation of cytoplasmic translation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H9Z2	P		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H9Z2	C		Seeded From UniProt	complete
enables	GO:1905538	polysome binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H9Z2	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060964	regulation of gene silencing by miRNA	PMID:19898466^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2685973	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045727	positive regulation of translation	PMID:17473174^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045686	negative regulation of glial cell differentiation	PMID:20179095^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	PMID:20179095^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035198	miRNA binding	PMID:18604195^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035198	miRNA binding	PMID:18604195^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0002322)	Seeded From UniProt	complete
enables	GO:0031369	translation initiation factor binding	PMID:17473174^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8JZQ9	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031123	RNA 3'-end processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H9Z2	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031054	pre-miRNA processing	PMID:18604195^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002322)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031054	pre-miRNA processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H9Z2	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019827	stem cell population maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H9Z2	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010587	miRNA catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H9Z2	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010586	miRNA metabolic process	PMID:20179095^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H9Z2	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007281	germ cell development	PMID:19578360^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99655	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007281	germ cell development	PMID:19578360^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005844	polysome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H9Z2	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18604195^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17473174^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12798299^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20014101^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H9Z2	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18604195^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H9Z2	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:17473174^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H9Z2	C		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:17473174^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H9Z2	F		Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H9Z2	C		Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H9Z2 ensembl:ENSP00000363314	P		Seeded From UniProt	complete
involved_in	GO:0010587	miRNA catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H9Z2 ensembl:ENSP00000363314	P		Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H9Z2 ensembl:ENSP00000363314	C		Seeded From UniProt	complete
part_of	GO:0005844	polysome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H9Z2 ensembl:ENSP00000363314	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H9Z2 ensembl:ENSP00000363314	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H9Z2 ensembl:ENSP00000363314	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H9Z2 ensembl:ENSP00000363314	F		Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H9Z2 ensembl:ENSP00000363314	C		Seeded From UniProt	complete
involved_in	GO:2000767	positive regulation of cytoplasmic translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H9Z2 ensembl:ENSP00000363314	P		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H9Z2 ensembl:ENSP00000363314	C		Seeded From UniProt	complete
enables	GO:1905538	polysome binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H9Z2 ensembl:ENSP00000363314	F		Seeded From UniProt	complete
involved_in	GO:0031123	RNA 3'-end processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H9Z2 ensembl:ENSP00000363314	P		Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9H9Z2 ensembl:ENSP00000363314	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001878 InterPro:IPR002059 InterPro:IPR011129 InterPro:IPR036875	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001878 InterPro:IPR036875	F		Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0943	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0496	C		Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0235	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0230	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Heo, I et al. (2008) Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol. Cell 32 276-84 PubMed GONUTS page
↑ Faehnle, CR et al. (2017) Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis. Nat. Struct. Mol. Biol. 24 658-665 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Cho, J et al. (2012) LIN28A is a suppressor of ER-associated translation in embryonic stem cells. Cell 151 765-77 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 O'Day, E et al. (2015) An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates. J. Biol. Chem. 290 17909-22 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Zhu, H et al. (2011) The Lin28/let-7 axis regulates glucose metabolism. Cell 147 81-94 PubMed GONUTS page
↑ Urbach, A et al. (2014) Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev. 28 971-82 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Rybak, A et al. (2008) A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat. Cell Biol. 10 987-93 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Viswanathan, SR et al. (2008) Selective blockade of microRNA processing by Lin28. Science 320 97-100 PubMed GONUTS page
↑ Rybak, A et al. (2009) The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat. Cell Biol. 11 1411-20 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Polesskaya, A et al. (2007) Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency. Genes Dev. 21 1125-38 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Balzer, E et al. (2010) LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro. Development 137 891-900 PubMed GONUTS page
↑ ^12.0 ^12.1 West, JA et al. (2009) A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature 460 909-13 PubMed GONUTS page
↑ Moss, EG & Tang, L (2003) Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites. Dev. Biol. 258 432-42 PubMed GONUTS page
↑ Hu, J et al. (2010) Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and its dominant-negative mutant caused two-cell-stage embryonic arrest. Dev. Dyn. 239 407-24 PubMed GONUTS page

[PMID:18951094-1] 1.0 ^1.1 Heo, I et al. (2008) Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol. Cell 32 276-84 PubMed GONUTS page

[PMID:28671666-2] Faehnle, CR et al. (2017) Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis. Nat. Struct. Mol. Biol. 24 658-665 PubMed GONUTS page

[PMID:23102813-3] 3.0 ^3.1 ^3.2 Cho, J et al. (2012) LIN28A is a suppressor of ER-associated translation in embryonic stem cells. Cell 151 765-77 PubMed GONUTS page

[PMID:26045559-4] 4.0 ^4.1 ^4.2 O'Day, E et al. (2015) An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates. J. Biol. Chem. 290 17909-22 PubMed GONUTS page

[PMID:21962509-5] 5.0 ^5.1 ^5.2 ^5.3 Zhu, H et al. (2011) The Lin28/let-7 axis regulates glucose metabolism. Cell 147 81-94 PubMed GONUTS page

[PMID:24732380-6] Urbach, A et al. (2014) Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev. 28 971-82 PubMed GONUTS page

[PMID:18604195-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Rybak, A et al. (2008) A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat. Cell Biol. 10 987-93 PubMed GONUTS page

[PMID:18292307-8] 8.0 ^8.1 ^8.2 ^8.3 Viswanathan, SR et al. (2008) Selective blockade of microRNA processing by Lin28. Science 320 97-100 PubMed GONUTS page

[PMID:19898466-9] Rybak, A et al. (2009) The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat. Cell Biol. 11 1411-20 PubMed GONUTS page

[PMID:17473174-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Polesskaya, A et al. (2007) Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency. Genes Dev. 21 1125-38 PubMed GONUTS page

[PMID:20179095-11] 11.0 ^11.1 ^11.2 Balzer, E et al. (2010) LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro. Development 137 891-900 PubMed GONUTS page

[PMID:19578360-12] 12.0 ^12.1 West, JA et al. (2009) A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature 460 909-13 PubMed GONUTS page

[PMID:12798299-13] Moss, EG & Tang, L (2003) Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites. Dev. Biol. 258 432-42 PubMed GONUTS page

[PMID:20014101-14] Hu, J et al. (2010) Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and its dominant-negative mutant caused two-cell-stage embryonic arrest. Dev. Dyn. 239 407-24 PubMed GONUTS page

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MOUSE:LN28A

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