MOUSE:LMNB1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Lmnb1
Protein Name(s)	Lamin-B1
External Links
UniProt	P14733
EMBL	X16705 M35153 D50080 BC052729 BC058392
CCDS	CCDS29261.1
PIR	S07720
RefSeq	NP_034851.2
UniGene	Mm.4105
ProteinModelPortal	P14733
SMR	P14733
BioGrid	201177
IntAct	P14733
MINT	MINT-1726964
PhosphoSite	P14733
REPRODUCTION-2DPAGE	IPI00230394
SWISS-2DPAGE	P14733
MaxQB	P14733
PaxDb	P14733
PRIDE	P14733
Ensembl	ENSMUST00000025486
GeneID	16906
KEGG	mmu:16906
UCSC	uc012bdd.2
CTD	4001
MGI	MGI:96795
eggNOG	NOG325506
GeneTree	ENSGT00760000118905
HOGENOM	HOG000007711
HOVERGEN	HBG013015
InParanoid	P14733
KO	K07611
OMA	QKESRAC
OrthoDB	EOG7MD4PW
PhylomeDB	P14733
TreeFam	TF101181
Reactome	REACT_198626 REACT_209025 REACT_209428 REACT_75800
ChiTaRS	Lmnb1
NextBio	290940
PRO	PR:P14733
Proteomes	UP000000589
Bgee	P14733
CleanEx	MM_LMNB1
Genevestigator	P14733
GO	GO:0005638 GO:0005635 GO:0005637 GO:0005654 GO:0005634 GO:0008432 GO:0043274 GO:0005198 GO:0031662 GO:0046330
Gene3D	2.60.40.1260
InterPro	IPR001664 IPR018039 IPR027696 IPR001322
PANTHER	PTHR23239 PTHR23239:SF157
Pfam	PF00038 PF00932
SUPFAM	SSF74853
PROSITE	PS00226

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005635	nuclear envelope	PMID:23166514^[1]	ECO:0000314			C		According to Figure 2, Lamin B1 shows variation in length of glutamic acid repeat, which greatly affects mobility within the nuclear envelope.	complete CACAO 7518
part_of	GO:0005635	nuclear envelope	PMID:23166514^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:19028838^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	PMID:19028838^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Z1B3	F		Seeded From UniProt	complete
involved_in	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	PMID:19028838^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008432	JUN kinase binding	PMID:19028838^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:19028838^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:19028838^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1990837	sequence-specific double-stranded DNA binding	PMID:23117660^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904609	cellular response to monosodium L-glutamate	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620522	P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P20700	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620522	C		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	PMID:20153721^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620522	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620522	C		Seeded From UniProt	complete
part_of	GO:0005652	nuclear lamina	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620522	C		Seeded From UniProt	complete
part_of	GO:0005638	lamin filament	PMID:8032679^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	PMID:25123547^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:20457914^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:16364897^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620522	C		Seeded From UniProt	complete
colocalizes_with	GO:0005635	nuclear envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P20700	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23028340^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21874024^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21503901^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12714744^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P20700	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620522	C		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:29484800^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20700 ensembl:ENSP00000261366	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20700 ensembl:ENSP00000261366	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P20700 ensembl:ENSP00000261366	C		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001664	F		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001664	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-8868383	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	Reactome:R-MMU-912355	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0403	C		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0179	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 De Castro, SC et al. (2012) Lamin b1 polymorphism influences morphology of the nuclear envelope, cell cycle progression, and risk of neural tube defects in mice. PLoS Genet. 8 e1003059 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Fiume, R et al. (2009) Involvement of nuclear PLCbeta1 in lamin B1 phosphorylation and G2/M cell cycle progression. FASEB J. 23 957-66 PubMed GONUTS page
↑ Fouillade, C et al. (2013) Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arterioscler. Thromb. Vasc. Biol. 33 76-86 PubMed GONUTS page
↑ Eto, K et al. (2010) Phosphorylated SAP155, the spliceosomal component, is localized to chromatin in postnatal mouse testes. Biochem. Biophys. Res. Commun. 393 577-81 PubMed GONUTS page
↑ Furukawa, K et al. (1994) cDNA cloning and functional characterization of a meiosis-specific protein (MNS1) with apparent nuclear association. Chromosome Res. 2 99-113 PubMed GONUTS page
↑ Karmodiya, K et al. (2014) Camello, a novel family of Histone Acetyltransferases that acetylate histone H4 and is essential for zebrafish development. Sci Rep 4 6076 PubMed GONUTS page
↑ Kim, CE et al. (2010) A molecular mechanism underlying the neural-specific defect in torsinA mutant mice. Proc. Natl. Acad. Sci. U.S.A. 107 9861-6 PubMed GONUTS page
↑ Goodchild, RE et al. (2005) Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope. Neuron 48 923-32 PubMed GONUTS page
↑ Cocquet, J et al. (2012) A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse. PLoS Genet. 8 e1002900 PubMed GONUTS page
↑ Chang, M et al. (2011) The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat. Immunol. 12 1002-9 PubMed GONUTS page
↑ Davis, H et al. (2011) FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. J. Pathol. 224 180-9 PubMed GONUTS page
↑ Burns, KH et al. (2003) Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos. Science 300 633-6 PubMed GONUTS page
↑ Whitton, H et al. (2018) Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver. Aging Cell 17 e12742 PubMed GONUTS page

[PMID:23166514-1] 1.0 ^1.1 De Castro, SC et al. (2012) Lamin b1 polymorphism influences morphology of the nuclear envelope, cell cycle progression, and risk of neural tube defects in mice. PLoS Genet. 8 e1003059 PubMed GONUTS page

[PMID:19028838-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Fiume, R et al. (2009) Involvement of nuclear PLCbeta1 in lamin B1 phosphorylation and G2/M cell cycle progression. FASEB J. 23 957-66 PubMed GONUTS page

[PMID:23117660-3] Fouillade, C et al. (2013) Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arterioscler. Thromb. Vasc. Biol. 33 76-86 PubMed GONUTS page

[PMID:20153721-4] Eto, K et al. (2010) Phosphorylated SAP155, the spliceosomal component, is localized to chromatin in postnatal mouse testes. Biochem. Biophys. Res. Commun. 393 577-81 PubMed GONUTS page

[PMID:8032679-5] Furukawa, K et al. (1994) cDNA cloning and functional characterization of a meiosis-specific protein (MNS1) with apparent nuclear association. Chromosome Res. 2 99-113 PubMed GONUTS page

[PMID:25123547-6] Karmodiya, K et al. (2014) Camello, a novel family of Histone Acetyltransferases that acetylate histone H4 and is essential for zebrafish development. Sci Rep 4 6076 PubMed GONUTS page

[PMID:20457914-7] Kim, CE et al. (2010) A molecular mechanism underlying the neural-specific defect in torsinA mutant mice. Proc. Natl. Acad. Sci. U.S.A. 107 9861-6 PubMed GONUTS page

[PMID:16364897-8] Goodchild, RE et al. (2005) Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope. Neuron 48 923-32 PubMed GONUTS page

[PMID:23028340-9] Cocquet, J et al. (2012) A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse. PLoS Genet. 8 e1002900 PubMed GONUTS page

[PMID:21874024-10] Chang, M et al. (2011) The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat. Immunol. 12 1002-9 PubMed GONUTS page

[PMID:21503901-11] Davis, H et al. (2011) FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. J. Pathol. 224 180-9 PubMed GONUTS page

[PMID:12714744-12] Burns, KH et al. (2003) Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos. Science 300 633-6 PubMed GONUTS page

[PMID:29484800-13] Whitton, H et al. (2018) Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver. Aging Cell 17 e12742 PubMed GONUTS page

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MOUSE:LMNB1

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