MOUSE:LHX2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Lhx2
Protein Name(s)	LIM/homeobox protein Lhx2 Homeobox protein LH-2 LIM homeobox protein 2
External Links
UniProt	Q9Z0S2
EMBL	AF124734 BC055741
CCDS	CCDS16008.1
RefSeq	NP_034840.1
UniGene	Mm.142856
ProteinModelPortal	Q9Z0S2
SMR	Q9Z0S2
BioGrid	201155
PhosphoSite	Q9Z0S2
PaxDb	Q9Z0S2
PRIDE	Q9Z0S2
Ensembl	ENSMUST00000000253
GeneID	16870
KEGG	mmu:16870
UCSC	uc008jnk.1
CTD	9355
MGI	MGI:96785
eggNOG	NOG240987
GeneTree	ENSGT00760000118921
HOGENOM	HOG000034022
HOVERGEN	HBG006262
InParanoid	Q9Z0S2
KO	K09373
OMA	HECRSPS
PhylomeDB	Q9Z0S2
TreeFam	TF315442
NextBio	290834
PRO	PR:Q9Z0S2
Proteomes	UP000000589
Bgee	Q9Z0S2
CleanEx	MM_LHX2
ExpressionAtlas	Q9Z0S2
Genevestigator	Q9Z0S2
GO	GO:0005622 GO:0005634 GO:0003682 GO:0001076 GO:0043565 GO:0008270 GO:0048646 GO:0048675 GO:0007411 GO:0007420 GO:0021987 GO:0009953 GO:0001942 GO:0045199 GO:0007498 GO:2000678 GO:0007399 GO:0001843 GO:0022008 GO:0030182 GO:0021772 GO:0045944 GO:0045893 GO:0060041 GO:0021537 GO:0021978 GO:0006366
Gene3D	1.10.10.60 2.10.110.10
InterPro	IPR017970 IPR001356 IPR009057 IPR001781
Pfam	PF00046 PF00412
SMART	SM00389 SM00132
SUPFAM	SSF46689
PROSITE	PS00027 PS50071 PS00478 PS50023

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:22734700^[1]	ECO:0000315			P		Fig 4 shows that LHX2 positively regulates transcription of gene CYP19A.	complete CACAO 6352
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:22457488^[2]	ECO:0000315			P		Fig 4 shows that in thalamic-projecting neurons, LHX2 regulates the expression of ROBO1 and ROBO2.	complete CACAO 6353
	GO:0007411	axon guidance	PMID:22457488^[2]	ECO:0000315			P		Fig. 3 shows that normal levels of LHX2 in the thalamus regulate axon guidance.	complete CACAO 6354
involved_in	GO:0021987	cerebral cortex development	PMID:26371318^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000179	positive regulation of neural precursor cell proliferation	PMID:26371318^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:26371318^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26371318^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050768	negative regulation of neurogenesis	PMID:26371318^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:26371318^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:28053041^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:28053041^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050768	negative regulation of neurogenesis	PMID:28053041^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	PMID:28053041^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045814	negative regulation of gene expression, epigenetic	PMID:28053041^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:7513049^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:7513049^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:7513049^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:12640)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:7513049^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_regulation_target:(NCBI_Gene:1081)	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:22457488^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:22734700^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10593900^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267978 MGI:MGI:102673 MGI:MGI:1100513 MGI:MGI:1888519 MGI:MGI:96785 PANTHER:PTN000654232 UniProtKB:Q969G2 UniProtKB:Q9UBR4 WB:WBGene00000438 WB:WBGene00002988 WB:WBGene00003167 WB:WBGene00006654	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002023 FB:FBgn0267978 MGI:MGI:101776 MGI:MGI:102673 MGI:MGI:107792 MGI:MGI:1096343 MGI:MGI:1100513 MGI:MGI:1306803 MGI:MGI:1888519 MGI:MGI:96785 MGI:MGI:99783 PANTHER:PTN000654232 RGD:71076 UniProtKB:P53411 UniProtKB:Q90881 WB:WBGene00000438 WB:WBGene00002988 WB:WBGene00003000 WB:WBGene00003167 WB:WBGene00006654 ZFIN:ZDB-GENE-050114-2 ZFIN:ZDB-GENE-050114-3 ZFIN:ZDB-GENE-050417-210 ZFIN:ZDB-GENE-051220-1 ZFIN:ZDB-GENE-060728-1 ZFIN:ZDB-GENE-980526-131	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267978 MGI:MGI:1096343 MGI:MGI:1100513 MGI:MGI:1306803 MGI:MGI:96785 MGI:MGI:99783 PANTHER:PTN000654232 RGD:71074 UniProtKB:O60663 UniProtKB:O97581 UniProtKB:P53411 UniProtKB:Q9UPM6 WB:WBGene00000438 WB:WBGene00002987 WB:WBGene00002988 WB:WBGene00003167	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1100513 MGI:MGI:1888519 MGI:MGI:96785 PANTHER:PTN000654232 UniProtKB:Q9UBR4	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267978 MGI:MGI:1100513 MGI:MGI:1888519 MGI:MGI:96785 PANTHER:PTN000654232 WB:WBGene00000438 WB:WBGene00002987 WB:WBGene00006654	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000678	negative regulation of transcription regulatory region DNA binding	PMID:9697309^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97168	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060041	retina development in camera-type eye	PMID:19146846^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97490	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048675	axon extension	PMID:21857657^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048646	anatomical structure formation involved in morphogenesis	PMID:11719201^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1890208	P	results_in_formation_of:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19146846^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97490	P	has_regulation_target:(MGI:MGI:1341840)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10431247^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1342291	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24012369^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000723) occurs_in:(CL:0000723) occurs_in:(EMAPA:18771) occurs_in:(EMAPA:18771) has_regulation_target:(MGI:MGI:1202876) has_regulation_target:(MGI:MGI:1202876) has_regulation_target:(MGI:MGI:1202879) has_regulation_target:(MGI:MGI:1202879) has_regulation_target:(MGI:MGI:1891468) has_regulation_target:(MGI:MGI:1891468) has_regulation_target:(MGI:MGI:1888513) has_regulation_target:(MGI:MGI:1888513) has_regulation_target:(MGI:MGI:88329) has_regulation_target:(MGI:MGI:88329) has_regulation_target:(MGI:MGI:1889272) has_regulation_target:(MGI:MGI:1889272) has_regulation_target:(MGI:MGI:96615) has_regulation_target:(MGI:MGI:96615) has_regulation_target:(MGI:MGI:104750) has_regulation_target:(MGI:MGI:104750) has_regulation_target:(MGI:MGI:101972) has_regulation_target:(MGI:MGI:101972) has_regulation_target:(MGI:MGI:108559) has_regulation_target:(MGI:MGI:108559) has_regulation_target:(MGI:MGI:1919583) has_regulation_target:(MGI:MGI:1919583) has_regulation_target:(MGI:MGI:2446089) has_regulation_target:(MGI:MGI:2446089)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045199	maintenance of epithelial cell apical/basal polarity	PMID:24012369^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926500,MGI:MGI:3772179	P	occurs_in:(EMAPA:18771) occurs_in:(CL:0000723)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:15173589^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:2661338)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:15173589^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1890208	P	occurs_in:(EMAPA:17606) results_in_acquisition_of_features_of:(CL:0000207)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022008	neurogenesis	PMID:18184563^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021987	cerebral cortex development	PMID:19820705^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4399044	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021978	telencephalon regionalization	PMID:11719201^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88177 MGI:MGI:88180	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021978	telencephalon regionalization	PMID:11719201^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1890208	P	has_participant:(EMAPA:16910)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021772	olfactory bulb development	PMID:19820705^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4399044	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021537	telencephalon development	PMID:19820705^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4399044	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021537	telencephalon development	PMID:17493606^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1890208	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021537	telencephalon development	PMID:11719201^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1890208	P	results_in_development_of:(EMAPA:16910)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021537	telencephalon development	PMID:11165475^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1890208	P	results_in_development_of:(EMAPA:17548)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:14566948^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1890208	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:11165475^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1890208	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:17991461^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P70662	F	occurs_in:(EMAPA:17525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007498	mesoderm development	PMID:9247336^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1890208	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:15295034^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1890208	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:14566948^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1890208	P	results_in_development_of:(EMAPA:16910)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:17493606^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1890208	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007399	nervous system development	PMID:9247336^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1890208	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24012369^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18771) part_of:(CL:0000723)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18076286^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:24012369^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:18771) occurs_in:(CL:0000723)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:19146846^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001942	hair follicle development	PMID:24012369^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926500,MGI:MGI:3772179	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001843	neural tube closure	PMID:11719201^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1890208	P	has_participant:(EMAPA:16530)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9011146 Reactome:R-MMU-9011082 Reactome:R-MMU-9011075	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Honda, S et al. (2012) LIM-homeodomain transcription factor, Lhx2, is involved in transcriptional control of brain-specific promoter/exon 1f of the mouse aromatase gene. J. Neuroendocrinol. 24 1367-74 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Marcos-Mondéjar, P et al. (2012) The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors. J. Neurosci. 32 4372-85 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Hsu, LC et al. (2015) Lhx2 regulates the timing of β-catenin-dependent cortical neurogenesis. Proc. Natl. Acad. Sci. U.S.A. 112 12199-204 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Muralidharan, B et al. (2017) LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11. J. Neurosci. 37 194-203 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Roberson, MS et al. (1994) Activation of the glycoprotein hormone alpha-subunit promoter by a LIM-homeodomain transcription factor. Mol. Cell. Biol. 14 2985-93 PubMed GONUTS page
↑ Glenn, DJ & Maurer, RA (1999) MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J. Biol. Chem. 274 36159-67 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Bendall, AJ et al. (1998) Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity. Differentiation 63 151-7 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Tétreault, N et al. (2009) The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation. Dev. Biol. 327 541-50 PubMed GONUTS page
↑ Sanuki, R et al. (2011) miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression. Nat. Neurosci. 14 1125-34 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Monuki, ES et al. (2001) Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway. Neuron 32 591-604 PubMed GONUTS page
↑ Bach, I et al. (1999) RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat. Genet. 22 394-9 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Folgueras, AR et al. (2013) Architectural niche organization by LHX2 is linked to hair follicle stem cell function. Cell Stem Cell 13 314-27 PubMed GONUTS page
↑ ^14.0 ^14.1 Hirota, J & Mombaerts, P (2004) The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons. Proc. Natl. Acad. Sci. U.S.A. 101 8751-5 PubMed GONUTS page
↑ Choi, PS et al. (2008) Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron 57 41-55 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Chou, SJ et al. (2009) Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex. Nat. Neurosci. 12 1381-9 PubMed GONUTS page
↑ ^17.0 ^17.1 Lakhina, V et al. (2007) Early thalamocortical tract guidance and topographic sorting of thalamic projections requires LIM-homeodomain gene Lhx2. Dev. Biol. 306 703-13 PubMed GONUTS page
↑ ^18.0 ^18.1 Bulchand, S et al. (2001) LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem. Mech. Dev. 100 165-75 PubMed GONUTS page
↑ ^19.0 ^19.1 Vyas, A et al. (2003) Paleocortex is specified in mice in which dorsal telencephalic patterning is severely disrupted. J. Comp. Neurol. 466 545-53 PubMed GONUTS page
↑ Xu, X et al. (2007) Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells. Dev. Biol. 312 484-500 PubMed GONUTS page
↑ ^21.0 ^21.1 Porter, FD et al. (1997) Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development 124 2935-44 PubMed GONUTS page
↑ Remedios, R et al. (2004) LIM genes parcellate the embryonic amygdala and regulate its development. J. Neurosci. 24 6986-90 PubMed GONUTS page
↑ Kittappa, R et al. (2007) The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol. 5 e325 PubMed GONUTS page

[PMID:22734700-1] 1.0 ^1.1 Honda, S et al. (2012) LIM-homeodomain transcription factor, Lhx2, is involved in transcriptional control of brain-specific promoter/exon 1f of the mouse aromatase gene. J. Neuroendocrinol. 24 1367-74 PubMed GONUTS page

[PMID:22457488-2] 2.0 ^2.1 ^2.2 Marcos-Mondéjar, P et al. (2012) The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors. J. Neurosci. 32 4372-85 PubMed GONUTS page

[PMID:26371318-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Hsu, LC et al. (2015) Lhx2 regulates the timing of β-catenin-dependent cortical neurogenesis. Proc. Natl. Acad. Sci. U.S.A. 112 12199-204 PubMed GONUTS page

[PMID:28053041-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Muralidharan, B et al. (2017) LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11. J. Neurosci. 37 194-203 PubMed GONUTS page

[PMID:7513049-5] 5.0 ^5.1 ^5.2 ^5.3 Roberson, MS et al. (1994) Activation of the glycoprotein hormone alpha-subunit promoter by a LIM-homeodomain transcription factor. Mol. Cell. Biol. 14 2985-93 PubMed GONUTS page

[PMID:10593900-6] Glenn, DJ & Maurer, RA (1999) MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J. Biol. Chem. 274 36159-67 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9697309-8] Bendall, AJ et al. (1998) Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity. Differentiation 63 151-7 PubMed GONUTS page

[PMID:19146846-9] 9.0 ^9.1 ^9.2 Tétreault, N et al. (2009) The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation. Dev. Biol. 327 541-50 PubMed GONUTS page

[PMID:21857657-10] Sanuki, R et al. (2011) miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression. Nat. Neurosci. 14 1125-34 PubMed GONUTS page

[PMID:11719201-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Monuki, ES et al. (2001) Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway. Neuron 32 591-604 PubMed GONUTS page

[PMID:10431247-12] Bach, I et al. (1999) RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat. Genet. 22 394-9 PubMed GONUTS page

[PMID:24012369-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Folgueras, AR et al. (2013) Architectural niche organization by LHX2 is linked to hair follicle stem cell function. Cell Stem Cell 13 314-27 PubMed GONUTS page

[PMID:15173589-14] 14.0 ^14.1 Hirota, J & Mombaerts, P (2004) The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons. Proc. Natl. Acad. Sci. U.S.A. 101 8751-5 PubMed GONUTS page

[PMID:18184563-15] Choi, PS et al. (2008) Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron 57 41-55 PubMed GONUTS page

[PMID:19820705-16] 16.0 ^16.1 ^16.2 Chou, SJ et al. (2009) Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex. Nat. Neurosci. 12 1381-9 PubMed GONUTS page

[PMID:17493606-17] 17.0 ^17.1 Lakhina, V et al. (2007) Early thalamocortical tract guidance and topographic sorting of thalamic projections requires LIM-homeodomain gene Lhx2. Dev. Biol. 306 703-13 PubMed GONUTS page

[PMID:11165475-18] 18.0 ^18.1 Bulchand, S et al. (2001) LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem. Mech. Dev. 100 165-75 PubMed GONUTS page

[PMID:14566948-19] 19.0 ^19.1 Vyas, A et al. (2003) Paleocortex is specified in mice in which dorsal telencephalic patterning is severely disrupted. J. Comp. Neurol. 466 545-53 PubMed GONUTS page

[PMID:17991461-20] Xu, X et al. (2007) Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells. Dev. Biol. 312 484-500 PubMed GONUTS page

[PMID:9247336-21] 21.0 ^21.1 Porter, FD et al. (1997) Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development 124 2935-44 PubMed GONUTS page

[PMID:15295034-22] Remedios, R et al. (2004) LIM genes parcellate the embryonic amygdala and regulate its development. J. Neurosci. 24 6986-90 PubMed GONUTS page

[PMID:18076286-23] Kittappa, R et al. (2007) The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol. 5 e325 PubMed GONUTS page

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MOUSE:LHX2

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