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MOUSE:LEG3
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Lgals3 | |
| Protein Name(s) | Galectin-3
Gal-3 35 kDa lectin Carbohydrate-binding protein 35 CBP 35 Galactose-specific lectin 3 IgE-binding protein L-34 galactoside-binding lectin Laminin-binding protein Lectin L-29 Mac-2 antigen | |
| External Links | ||
| UniProt | P16110 | |
| EMBL | X16834 J03723 X16074 | |
| CCDS | CCDS26986.1 | |
| PIR | S08537 | |
| UniGene | Mm.248615 | |
| ProteinModelPortal | P16110 | |
| SMR | P16110 | |
| DIP | DIP-2152N | |
| IntAct | P16110 | |
| STRING | 10090.ENSMUSP00000022388 | |
| BindingDB | P16110 | |
| ChEMBL | CHEMBL3668 | |
| PhosphoSite | P16110 | |
| MaxQB | P16110 | |
| PaxDb | P16110 | |
| PRIDE | P16110 | |
| MGI | MGI:96778 | |
| eggNOG | NOG312075 | |
| HOGENOM | HOG000246423 | |
| HOVERGEN | HBG006255 | |
| InParanoid | P16110 | |
| ChiTaRS | Lgals3 | |
| PRO | PR:P16110 | |
| Proteomes | UP000000589 | |
| CleanEx | MM_LGALS3 | |
| Genevestigator | P16110 | |
| GO | GO:0005737 GO:0009897 GO:0001772 GO:0005634 GO:0005578 GO:0005681 GO:0030246 GO:0030154 GO:0030198 GO:0045087 GO:0006397 GO:0045806 GO:2000521 GO:2001189 GO:0050860 GO:0008380 GO:0001501 | |
| Gene3D | 2.60.120.200 | |
| InterPro | IPR013320 IPR015534 IPR001079 | |
| PANTHER | PTHR11346:SF26 | |
| Pfam | PF00337 | |
| SMART | SM00908 SM00276 | |
| SUPFAM | SSF49899 | |
| PROSITE | PS51304 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0009986 |
cell surface |
ECO:0000314 |
C |
Gal-3 is known to be expressed on the cell surface of human Eos, but Mouse Eos express Gal-3 as well. Figure 2B shows cell surface expression of Gal-3 in non-permeabilized BM-derived Eos. |
complete | |||||
| GO:0008380 |
RNA splicing |
ECO:0000314 |
P |
Acts a pre-mRNA splicing factor in the nucleus. |
complete | |||||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0002048) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001155) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
produced_by:(CL:0002548) |
Seeded From UniProt |
complete | ||
|
NOT|involved_in |
GO:0045185 |
maintenance of protein location |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2001189 |
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000521 |
negative regulation of immunological synapse formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050860 |
negative regulation of T cell receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045806 |
negative regulation of endocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001772 |
immunological synapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2001237 |
negative regulation of extrinsic apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1903769 |
negative regulation of cell proliferation in bone marrow |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69356 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1903078 |
positive regulation of protein localization to plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1902041 |
regulation of extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097386 |
glial cell projection |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0090280 |
positive regulation of calcium ion import |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0090073 |
positive regulation of protein homodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071677 |
positive regulation of mononuclear cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071674 |
mononuclear cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070232 |
regulation of T cell apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050918 |
positive chemotaxis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0050785 |
advanced glycation end-product receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69356 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048246 |
macrophage chemotaxis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0048245 |
eosinophil chemotaxis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0048030 |
disaccharide binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69356 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0048029 |
monosaccharide binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69356 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045806 |
negative regulation of endocytosis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045766 |
positive regulation of angiogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69356 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043236 |
laminin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69356 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042129 |
regulation of T cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042056 |
chemoattractant activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034988 |
Fc-gamma receptor I complex binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69356 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:36159) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0030593 |
neutrophil chemotaxis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030198 |
extracellular matrix organization |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:97011 |
P |
occurs_in:(EMAPA:36159) |
Seeded From UniProt |
complete | |
|
enables |
GO:0019903 |
protein phosphatase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019863 |
IgE binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019863 |
IgE binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69356 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0014064 |
positive regulation of serotonin secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69356 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69356 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69356 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69356 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69356 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69356 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0002548 |
monocyte chemotaxis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001772 |
immunological synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001501 |
skeletal system development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:97011 |
P |
results_in_development_of:(EMAPA:36159) |
Seeded From UniProt |
complete | |
|
enables |
GO:0030246 |
carbohydrate binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-MMU-8878599 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008380 |
RNA splicing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019863 |
IgE binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006397 |
mRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005681 |
spliceosomal complex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030246 |
carbohydrate binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Ge, XN et al. (2013) Eosinophil-expressed galectin-3 regulates cell trafficking and migration. Front Pharmacol 4 37 PubMed GONUTS page
- ↑ Coppin, L et al. (2017) Galectin-3 is a non-classic RNA binding protein that stabilizes the mucin MUC4 mRNA in the cytoplasm of cancer cells. Sci Rep 7 43927 PubMed GONUTS page
- ↑ 3.0 3.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page
- ↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
- ↑ Bi, S et al. (2011) Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry. Proc. Natl. Acad. Sci. U.S.A. 108 10650-5 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Chen, HY et al. (2009) Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse. Proc. Natl. Acad. Sci. U.S.A. 106 14496-501 PubMed GONUTS page
- ↑ Hideyama, T et al. (2010) Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2. J. Neurosci. 30 11917-25 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Ortega, N et al. (2005) Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation. Mol. Biol. Cell 16 3028-39 PubMed GONUTS page
- ↑ Poddar, D et al. (2013) An extraribosomal function of ribosomal protein L13a in macrophages resolves inflammation. J. Immunol. 190 3600-12 PubMed GONUTS page
- ↑ Crider-Pirkle, S et al. (2002) Cubilin, a binding partner for galectin-3 in the murine utero-placental complex. J. Biol. Chem. 277 15904-12 PubMed GONUTS page
- ↑ 11.0 11.1 Menon, RP et al. (2000) Interaction of a novel cysteine and histidine-rich cytoplasmic protein with galectin-3 in a carbohydrate-independent manner. FEBS Lett. 470 227-31 PubMed GONUTS page
c
e
i
m
- GO:0048246 ! macrophage chemotaxis
- GO:0045185 ! maintenance of protein location
- Mammalia
- Metazoa
- GO:0005743 ! mitochondrial inner membrane
- GO:0002548 ! monocyte chemotaxis
- GO:0071674 ! mononuclear cell migration
- GO:0048029 ! monosaccharide binding
- GO:0006397 ! mRNA processing
- Muridae
- Murinae
- Muroidea
- Mus
- Mus musculus
n
- GO:0043066 ! negative regulation of apoptotic process
- GO:0045806 ! negative regulation of endocytosis
- GO:2001189 ! negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
- GO:1903769 ! negative regulation of cell proliferation in bone marrow
- GO:2001237 ! negative regulation of extrinsic apoptotic signaling pathway
- GO:2000521 ! negative regulation of immunological synapse formation
- GO:0050860 ! negative regulation of T cell receptor signaling pathway
- GO:0030593 ! neutrophil chemotaxis
- GO:0005634 ! nucleus
p
- GO:0050918 ! positive chemotaxis
- GO:1903078 ! positive regulation of protein localization to plasma membrane
- GO:0090280 ! positive regulation of calcium ion import
- GO:0045766 ! positive regulation of angiogenesis
- GO:0014064 ! positive regulation of serotonin secretion
- GO:0071677 ! positive regulation of mononuclear cell migration
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0019903 ! protein phosphatase binding
r
