MOUSE:KPYM

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pkm (synonyms: Pk3, Pkm2, Pykm)
Protein Name(s)	Pyruvate kinase PKM Pyruvate kinase muscle isozyme
External Links
UniProt	P52480
EMBL	D38379 X97047 AK002341 AK135397 AK151724 AK153483 AK155110 AK155655 AK170892 AK168943 AK171023 AK171033 AC160637 BC016619 BC094663
CCDS	CCDS40659.1 CCDS57681.1
PIR	S55921
RefSeq	NP_001240812.1 NP_035229.2 XP_006510918.1
UniGene	Mm.326167 Mm.488724
ProteinModelPortal	P52480
SMR	P52480
BioGrid	202191
IntAct	P52480
MINT	MINT-1850796
PhosphoSite	P52480
REPRODUCTION-2DPAGE	IPI00407130 P52480
SWISS-2DPAGE	P52480
MaxQB	P52480
PaxDb	P52480
PRIDE	P52480
Ensembl	ENSMUST00000034834 ENSMUST00000163694
GeneID	18746
KEGG	mmu:18746
UCSC	uc009pyf.2 uc009pyh.2
CTD	5315
MGI	MGI:97591
eggNOG	COG0469
GeneTree	ENSGT00390000008859
HOVERGEN	HBG000941
InParanoid	P52480
KO	K00873
OMA	DVPYFEK
OrthoDB	EOG78M01Q
PhylomeDB	P52480
TreeFam	TF300390
Reactome	REACT_232322
SABIO-RK	P52480
UniPathway	UPA00109
NextBio	294905
PRO	PR:P52480
Proteomes	UP000000589
Bgee	P52480
CleanEx	MM_PKM2
Genevestigator	P52480
GO	GO:0005929 GO:0031012 GO:0070062 GO:0005739 GO:0005634 GO:0005886 GO:0005524 GO:0000287 GO:0044822 GO:0030955 GO:0004743 GO:0006096 GO:0012501
Gene3D	2.40.33.10 3.20.20.60 3.40.1380.20
InterPro	IPR001697 IPR015813 IPR011037 IPR015794 IPR018209 IPR015793 IPR015795 IPR015806
PANTHER	PTHR11817
Pfam	PF00224 PF02887
PRINTS	PR01050
SUPFAM	SSF50800 SSF51621 SSF52935
TIGRFAMs	TIGR01064
PROSITE	PS00110

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P14618	P		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:17634366^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:23658023^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000212861 RGD:3336	P		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10803 EcoGene:EG10804 MGI:MGI:97591 PANTHER:PTN000212670 RGD:3336 RGD:3337 SGD:S000000036 UniProtKB:Q2RAK2	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000212670 SGD:S000000036 UniProtKB:P14618	C		Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10803 EcoGene:EG10804 MGI:MGI:97591 MGI:MGI:97604 PANTHER:PTN000212670 PomBase:SPAC4H3.10c RGD:3336 RGD:3337 SGD:S000000036 SGD:S000005874 TAIR:locus:2033760 TAIR:locus:2084583 TAIR:locus:2176912 UniProtKB:C6KTA4 UniProtKB:P14618 UniProtKB:P30613 UniProtKB:Q2RAK2	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14618	P		Seeded From UniProt	complete
part_of	GO:1902912	pyruvate kinase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3337	C		Seeded From UniProt	complete
enables	GO:0070324	thyroid hormone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3337	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051289	protein homotetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3337	P		Seeded From UniProt	complete
enables	GO:0043531	ADP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3337	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043403	skeletal muscle tissue regeneration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3337	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042866	pyruvate biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3337	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3337	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031100	animal organ regeneration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3337	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0012501	programmed cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14618	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006754	ATP biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3337	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006096	glycolytic process	PMID:7295297^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006096	glycolytic process	PMID:7262549^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006096	glycolytic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3337	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006006	glucose metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3337	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:16687649^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14618	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14651853^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:16894)\|part_of:(EMAPA:17373)\|part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14618	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14618	C		Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	PMID:7295297^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16105)\|occurs_in:(EMAPA:16894)\|occurs_in:(EMAPA:32716)\|occurs_in:(EMAPA:17373)	Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	PMID:7262549^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:17373)	Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14618	F		Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3337	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001889	liver development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3337	P		Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14618 ensembl:ENSP00000320171	P		Seeded From UniProt	complete
involved_in	GO:0012501	programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14618 ensembl:ENSP00000320171	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14618 ensembl:ENSP00000320171	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14618 ensembl:ENSP00000320171	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14618 ensembl:ENSP00000320171	C		Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14618 ensembl:ENSP00000320171	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R5Z9 ensembl:ENSP00000320171	C		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001697 InterPro:IPR015793	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015813	F		Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001697 InterPro:IPR015793 InterPro:IPR015806 InterPro:IPR018209	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001697 InterPro:IPR015793 InterPro:IPR015806 InterPro:IPR018209	P		Seeded From UniProt	complete
enables	GO:0030955	potassium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001697 InterPro:IPR015793	F		Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.40	F		Seeded From UniProt	complete
part_of	GO:0001917	photoreceptor inner segment	PMID:26780311^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0324 UniPathway:UPA00109	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
↑ Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Peters, J et al. (1981) Polymorphism of kidney pyruvate kinase in the mouse is determined by a gene, Pk-3, on chromosome 9. Biochem. Genet. 19 757-69 PubMed GONUTS page
↑ ^5.0 ^5.1 Johnson, FM et al. (1981) A variation in mouse kidney pyruvate kinase activity determined by a mutant gene on chromosome 9. Genet. Res. 37 123-31 PubMed GONUTS page
↑ Krisfalusi, M et al. (2006) Multiple glycolytic enzymes are tightly bound to the fibrous sheath of mouse spermatozoa. Biol. Reprod. 75 270-8 PubMed GONUTS page
↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
↑ Casson, RJ et al. (2016) M-Type Pyruvate Kinase Isoforms and Lactate Dehydrogenase A in the Mammalian Retina: Metabolic Implications. Invest. Ophthalmol. Vis. Sci. 57 66-80 PubMed GONUTS page

[PMID:17634366-1] Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page

[PMID:23658023-2] Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7295297-4] 4.0 ^4.1 Peters, J et al. (1981) Polymorphism of kidney pyruvate kinase in the mouse is determined by a gene, Pk-3, on chromosome 9. Biochem. Genet. 19 757-69 PubMed GONUTS page

[PMID:7262549-5] 5.0 ^5.1 Johnson, FM et al. (1981) A variation in mouse kidney pyruvate kinase activity determined by a mutant gene on chromosome 9. Genet. Res. 37 123-31 PubMed GONUTS page

[PMID:16687649-6] Krisfalusi, M et al. (2006) Multiple glycolytic enzymes are tightly bound to the fibrous sheath of mouse spermatozoa. Biol. Reprod. 75 270-8 PubMed GONUTS page

[PMID:14651853-7] Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

[PMID:26780311-8] Casson, RJ et al. (2016) M-Type Pyruvate Kinase Isoforms and Lactate Dehydrogenase A in the Mammalian Retina: Metabolic Implications. Invest. Ophthalmol. Vis. Sci. 57 66-80 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

MOUSE:KPYM

Contents

Annotations

Notes

References

a

c

e

g

i

k

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools