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PMID:26780311
| Citation |
Casson, RJ, Wood, JP, Han, G, Kittipassorn, T, Peet, DJ and Chidlow, G (2016) M-Type Pyruvate Kinase Isoforms and Lactate Dehydrogenase A in the Mammalian Retina: Metabolic Implications. Invest. Ophthalmol. Vis. Sci. 57:66-80 |
|---|---|
| Abstract |
Like cancer cells, photoreceptor cells produce lactate aerobically, requiring lactate dehydrogenase A (LDH-A). Cancer cells also use glycolytic intermediates for biosynthesis. The molecular switch controlling glycolytic flow is thought to be an isoenzyme of pyruvate kinase (PKM2). Here, we determined the expression and localization of PKM2 and LDH-A in mammalian retina and make comparisons with the brain. |
| Links |
PubMed Online version:10.1167/iovs.15-17962 |
| Keywords |
Aged; Animals; Blotting, Western; Callithrix; Cell Line; Energy Metabolism/genetics; Humans; Immunohistochemistry; Isoenzymes/biosynthesis; Isoenzymes/genetics; L-Lactate Dehydrogenase/biosynthesis; L-Lactate Dehydrogenase/genetics; Mice; Mice, Inbred C57BL; Middle Aged; Pyruvate Kinase/biosynthesis; Pyruvate Kinase/genetics; RNA/genetics; Rabbits; Rats; Rats, Sprague-Dawley; Retina/cytology; Retina/enzymology; Reverse Transcriptase Polymerase Chain Reaction |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0001917: photoreceptor inner segment |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
Notes
See also
References
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