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MOUSE:KI67

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Mki67 (ECO:0000312 with MGI:MGI:106035)
Protein Name(s) Proliferation marker protein Ki-67 (ECO:0000305)

Antigen identified by monoclonal antibody Ki-67 homolog (ECO:0000305) Antigen KI-67 homolog (ECO:0000305) Antigen Ki67 homolog (ECO:0000305)

External Links
UniProt E9PVX6
EMBL X82786
AC123047
BC053453
CCDS CCDS52421.1
PIR T30249
RefSeq NP_001074586.2
UniGene Mm.4078
ProteinModelPortal E9PVX6
SMR E9PVX6
IntAct E9PVX6
MINT MINT-4109797
STRING 10090.ENSMUSP00000033310
iPTMnet E9PVX6
PhosphoSitePlus E9PVX6
MaxQB E9PVX6
PaxDb E9PVX6
PeptideAtlas E9PVX6
PRIDE E9PVX6
Ensembl ENSMUST00000033310
GeneID 17345
KEGG mmu:17345
UCSC uc009kem.2
CTD 4288
MGI MGI:106035
eggNOG ENOG410JR7C
ENOG410ZXYW
GeneTree ENSGT00530000064425
HOGENOM HOG000113223
HOVERGEN HBG006213
InParanoid E9PVX6
KO K17582
OMA TGLSKVD
OrthoDB EOG091G005S
TreeFam TF336000
ChiTaRS Mki67
PRO PR:E9PVX6
Proteomes UP000000589
Bgee ENSMUSG00000031004
ExpressionAtlas E9PVX6
Genevisible E9PVX6
GO GO:0000775
GO:0000793
GO:0005737
GO:0016020
GO:0016604
GO:0005730
GO:0005634
GO:0005524
GO:0003677
GO:0008022
GO:0003723
GO:0031100
GO:0008283
GO:0034605
GO:1990705
GO:0006259
GO:0072574
GO:0030212
GO:0007126
GO:1902275
GO:0051983
GO:0007088
GO:0014070
Gene3D 2.60.200.20
InterPro IPR000253
IPR012568
IPR029334
IPR008984
Pfam PF00498
PF08065
PF15276
SMART SM00240
SM01295
SUPFAM SSF49879
PROSITE PS50006

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

NOT|involved_in

GO:0008283

cell population proliferation

PMID:26949251[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051983

regulation of chromosome segregation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P46013

P

Seeded From UniProt

complete

involved_in

GO:0007088

regulation of mitotic nuclear division

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P46013

P

Seeded From UniProt

complete

involved_in

GO:1902275

regulation of chromatin organization

PMID:26949251[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1990705

cholangiocyte proliferation

PMID:25446530[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072574

hepatocyte proliferation

PMID:25446530[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051983

regulation of chromosome segregation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P46013

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051321

meiotic cell cycle

PMID:12355204[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016604

nuclear body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P46013

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008283

cell population proliferation

PMID:19303854[4]

ECO:0000314

direct assay evidence used in manual assertion

P

acts_on_population_of:(CL:0000646)|acts_on_population_of:(CL:0000362)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008283

cell population proliferation

PMID:12972605[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P46013

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007088

regulation of mitotic nuclear division

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P46013

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11731231[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:15237214[7]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16037)
  • part_of:(CL:0000007)|part_of:(EMAPA:16036)
  • part_of:(CL:0000007)

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:12355204[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P46013

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:25433207[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24582971[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24191021[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:23786676[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:23284756[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22984613[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21464233[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19409883[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18604197[16]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002327)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17257418[17]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32834)
  • part_of:(CL:0000164)|part_of:(EMAPA:32834)
  • part_of:(CL:0000066)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16314515[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15237214[7]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:16032)|part_of:(EMAPA:16034)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12368262[19]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:D4A0Y6

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P46013

C

Seeded From UniProt

complete

part_of

GO:0000793

condensed chromosome

PMID:12355204[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0000793

condensed chromosome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P46013

C

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

PMID:12355204[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158
UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Sobecki, M et al. (2016) The cell proliferation antigen Ki-67 organises heterochromatin. Elife 5 e13722 PubMed GONUTS page
  2. ↑ 2.0 2.1 Falix, FA et al. (2014) Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning. Dev. Biol. 396 201-13 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Traut, W et al. (2002) The temporal and spatial distribution of the proliferation associated Ki-67 protein during female and male meiosis. Chromosoma 111 156-64 PubMed GONUTS page
  4. ↑ Ezhkova, E et al. (2009) Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 136 1122-35 PubMed GONUTS page
  5. ↑ Khalili, K et al. (2003) Puralpha is essential for postnatal brain development and developmentally coupled cellular proliferation as revealed by genetic inactivation in the mouse. Mol. Cell. Biol. 23 6857-75 PubMed GONUTS page
  6. ↑ Ridanpää, M et al. (2001) Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures. Mech. Dev. 109 173-81 PubMed GONUTS page
  7. ↑ 7.0 7.1 Winking, H et al. (2004) Expression of the proliferation marker Ki-67 during early mouse development. Cytogenet. Genome Res. 105 251-6 PubMed GONUTS page
  8. ↑ Serinagaoglu, Y et al. (2015) Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Dev. Biol. 398 97-109 PubMed GONUTS page
  9. ↑ Murthy, M et al. (2014) Transcription factor Runx1 inhibits proliferation and promotes developmental maturation in a selected population of inner olfactory nerve layer olfactory ensheathing cells. Gene 540 191-200 PubMed GONUTS page
  10. ↑ Rockich, BE et al. (2013) Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 110 E4456-64 PubMed GONUTS page
  11. ↑ Sharma, P et al. (2013) Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN. Mol. Cancer 12 67 PubMed GONUTS page
  12. ↑ Krolewski, RC et al. (2012) Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium. PLoS ONE 7 e51737 PubMed GONUTS page
  13. ↑ Balasubramanian, S et al. (2012) β3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse. PLoS ONE 7 e45076 PubMed GONUTS page
  14. ↑ Osorio, KM et al. (2011) Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J. Cell Biol. 193 235-50 PubMed GONUTS page
  15. ↑ Okado, H et al. (2009) The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex. Dev. Biol. 331 140-51 PubMed GONUTS page
  16. ↑ Nojima, H et al. (2008) IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade. Nat. Cell Biol. 10 971-8 PubMed GONUTS page
  17. ↑ Yang, HS & Hinds, PW (2007) pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development. BMC Dev. Biol. 7 6 PubMed GONUTS page
  18. ↑ Marçal, N et al. (2005) Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation. Mol. Cell. Biol. 25 10916-29 PubMed GONUTS page
  19. ↑ Olave, I et al. (2002) Identification of a polymorphic, neuron-specific chromatin remodeling complex. Genes Dev. 16 2509-17 PubMed GONUTS page
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