MOUSE:JAG2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Jag2
Protein Name(s)	Protein jagged-2 Jagged2
External Links
UniProt	Q9QYE5
EMBL	AF038572 AC160929 AF010137 Y14495
CCDS	CCDS26200.1
RefSeq	NP_034718.2
UniGene	Mm.186146
ProteinModelPortal	Q9QYE5
SMR	Q9QYE5
PhosphoSite	Q9QYE5
PRIDE	Q9QYE5
Ensembl	ENSMUST00000075827
GeneID	16450
KEGG	mmu:16450
CTD	3714
MGI	MGI:1098270
eggNOG	NOG12793
GeneTree	ENSGT00760000118786
HOGENOM	HOG000113124
HOVERGEN	HBG031645
InParanoid	Q9QYE5
KO	K06052
OMA	GACCDGD
OrthoDB	EOG7BKCSS
TreeFam	TF351835
Reactome	REACT_196589 REACT_196591 REACT_196638 REACT_196643 REACT_199384 REACT_199404 REACT_199411 REACT_199413
NextBio	289709
PRO	PR:Q9QYE5
Proteomes	UP000000589
CleanEx	MM_JAG2
Genevestigator	Q9QYE5
GO	GO:0005887 GO:0016020 GO:0005886 GO:0005509 GO:0008083 GO:0009912 GO:0001709 GO:1990134 GO:0042492 GO:0001701 GO:0016331 GO:0007219 GO:0042475 GO:0030155 GO:0042127 GO:0003016 GO:0007605 GO:0001501 GO:0007283 GO:0045061
InterPro	IPR001774 IPR000742 IPR001881 IPR013032 IPR000152 IPR018097 IPR009030 IPR026219 IPR011651 IPR001007
Pfam	PF01414 PF00008 PF07645 PF07657
PRINTS	PR02059
SMART	SM00051 SM00181 SM00179 SM00214
SUPFAM	SSF57184
PROSITE	PS00010 PS51051 PS00022 PS01186 PS50026 PS01187

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
incorrect (CACAO)	GO:0060021	palate development	PMID:19341725^[1]	ECO:0000304			P		page 7 Abnormal palate-mandible fusion has been reported in Jagged2−/− ...mice...	complete
	GO:0001709	cell fate determination	PMID:10910909^[2]	ECO:0000303			P			complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	PMID:10958687^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005112	Notch binding	PMID:10958687^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O35516	F		Seeded From UniProt	complete
involved_in	GO:0045061	thymic T cell selection	PMID:10383933^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y219	P		Seeded From UniProt	complete
involved_in	GO:0042492	gamma-delta T cell differentiation	PMID:10383933^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:10383933^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y219	P		Seeded From UniProt	complete
involved_in	GO:0009912	auditory receptor cell fate commitment	PMID:10080181^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:10383933^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y219	F		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	PMID:10080181^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10910909^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001709	cell fate determination	PMID:10910909^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990134	epithelial cell apoptotic process involved in palatal shelf morphogenesis	PMID:16607638^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2657215	P	occurs_in:(EMAPA:17931) occurs_in:(CL:0000066)\|occurs_in:(EMAPA:17881) occurs_in:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2938	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045061	thymic T cell selection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y219	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:15721140^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2657215	P	has_participant:(EMAPA:17917)\|has_participant:(EMAPA:17938)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y219	P		Seeded From UniProt	complete
Colocalizes with	GO:0005737	cytoplasm	PMID:22652674^[8]	ECO:0000314			C		Figure 7A shows immnunostaining of Jagged2 in the cytoplasm: "At 19.5 dpc (the day of labor), Jagged2 was expressed in the cytoplasm of oocytes (A)"	complete CACAO 11678
acts_upstream_of_or_within	GO:0030217	T cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y219	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030155	regulation of cell adhesion	PMID:16607638^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2657215	P	regulates_o_occurs_in:(EMAPA:17931) regulates_o_has_participant:(CL:0000066)\|regulates_o_occurs_in(EMAPA:17935) regulates_o_has_participant:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y219	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016331	morphogenesis of embryonic epithelium	PMID:16607638^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2657215	P	has_participant:(EMAPA:17930)	Seeded From UniProt	complete
	GO:0045061	thymic T cell selection	PMID:10383933^[4]	ECO:0000250		UniProtKB:Q9Y219	P			complete
part_of	GO:0016020	membrane	PMID:15886206^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y219	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2938	P		Seeded From UniProt	complete
enables	GO:0005112	Notch binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y219	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003016	respiratory system process	PMID:9531541^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2657215	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:9531541^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2657215	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001501	skeletal system development	PMID:15721140^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2657215	P	results_in_development_of:(EMAPA:17928)\|results_in_development_of:(EMAPA:18290)	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0045061	thymic T cell selection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y219 ensembl:ENSP00000328169	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y219 ensembl:ENSP00000328169	P		Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y219 ensembl:ENSP00000328169	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y219 ensembl:ENSP00000328169	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y219 ensembl:ENSP00000328169	F		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y219 ensembl:ENSP00000328169	P		Seeded From UniProt	complete
enables	GO:0005112	Notch binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y219 ensembl:ENSP00000328169	F		Seeded From UniProt	complete
enables	GO:0005112	Notch binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026219	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001881 InterPro:IPR018097	F		Seeded From UniProt	complete
involved_in	GO:0007154	cell communication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001774	P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011651 InterPro:IPR026219	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011651	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001774	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011651	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-9013059 Reactome:R-MMU-2032379	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0914	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Xiong, W et al. (2009) Hand2 is required in the epithelium for palatogenesis in mice. Dev. Biol. 330 131-41 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Tsai, S et al. (2000) Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact. Blood 96 950-7 PubMed GONUTS page
↑ ^3.0 ^3.1 Shimizu, K et al. (2000) Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. Mol. Cell. Biol. 20 6913-22 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Felli, MP et al. (1999) Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. Int. Immunol. 11 1017-25 PubMed GONUTS page
↑ ^5.0 ^5.1 Lanford, PJ et al. (1999) Notch signalling pathway mediates hair cell development in mammalian cochlea. Nat. Genet. 21 289-92 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Casey, LM et al. (2006) Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development. Dev. Dyn. 235 1830-44 PubMed GONUTS page
↑ ^7.0 ^7.1 Mitsiadis, TA et al. (2005) Role of the Notch signalling pathway in tooth morphogenesis. Arch. Oral Biol. 50 137-40 PubMed GONUTS page
↑ Guo, M et al. (2012) P4 down-regulates Jagged2 and Notch1 expression during primordial folliculogenesis. Front Biosci (Elite Ed) 4 2731-44 PubMed GONUTS page
↑ Vetrivel, KS et al. (2005) Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J. Biol. Chem. 280 25892-900 PubMed GONUTS page
↑ ^10.0 ^10.1 Jiang, R et al. (1998) Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev. 12 1046-57 PubMed GONUTS page

[PMID:19341725-1] Xiong, W et al. (2009) Hand2 is required in the epithelium for palatogenesis in mice. Dev. Biol. 330 131-41 PubMed GONUTS page

[PMID:10910909-2] 2.0 ^2.1 ^2.2 Tsai, S et al. (2000) Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact. Blood 96 950-7 PubMed GONUTS page

[PMID:10958687-3] 3.0 ^3.1 Shimizu, K et al. (2000) Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. Mol. Cell. Biol. 20 6913-22 PubMed GONUTS page

[PMID:10383933-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Felli, MP et al. (1999) Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. Int. Immunol. 11 1017-25 PubMed GONUTS page

[PMID:10080181-5] 5.0 ^5.1 Lanford, PJ et al. (1999) Notch signalling pathway mediates hair cell development in mammalian cochlea. Nat. Genet. 21 289-92 PubMed GONUTS page

[PMID:16607638-6] 6.0 ^6.1 ^6.2 Casey, LM et al. (2006) Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development. Dev. Dyn. 235 1830-44 PubMed GONUTS page

[PMID:15721140-7] 7.0 ^7.1 Mitsiadis, TA et al. (2005) Role of the Notch signalling pathway in tooth morphogenesis. Arch. Oral Biol. 50 137-40 PubMed GONUTS page

[PMID:22652674-8] Guo, M et al. (2012) P4 down-regulates Jagged2 and Notch1 expression during primordial folliculogenesis. Front Biosci (Elite Ed) 4 2731-44 PubMed GONUTS page

[PMID:15886206-9] Vetrivel, KS et al. (2005) Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J. Biol. Chem. 280 25892-900 PubMed GONUTS page

[PMID:9531541-10] 10.0 ^10.1 Jiang, R et al. (1998) Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev. 12 1046-57 PubMed GONUTS page

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MOUSE:JAG2

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