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PMID:10383933
| Citation |
Felli, MP, Maroder, M, Mitsiadis, TA, Campese, AF, Bellavia, D, Vacca, A, Mann, RS, Frati, L, Lendahl, U, Gulino, A and Screpanti, I (1999) Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. Int. Immunol. 11:1017-25 |
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| Abstract |
The suggested role of Notch1 or its mutants in thymocyte differentiation and T cell tumorigenesis raises the question of how the different members of the Notch family influence distinct steps in T cell development and the role played by Notch ligands in the thymus. We report here that different Notch receptor-ligand partnerships may occur inside the thymus, as we observed differential expression of Notch1, 2 and 3 receptors, their ligands Jagged1 and 2, and downstream intracellular effectors hairy and Enhancer of Split homolog 1 (HES-1) and hairy and Enhancer of Split homolog 5 (HES-5), depending on ontogenetic stage and thymic cell populations. Indeed, while Jagged2 is expressed in both stromal cells and thymocytes, Jagged1 expression is restricted to stromal cells. Moreover, a differential distribution of Notch3, with respect to Notch1, was observed in distinct age-related thymocyte subsets. Finally, Notch3 was preferentially up-regulated in thymocytes, following the induction of their differentiation by interaction with thymic epithelial cells expressing the cognate Jagged1 and 2 ligands, suggesting that, besides Notch1, Notch3 may also be involved in distinct steps of thymocyte development. Our results suggest that the Notch signaling pathway is involved in a complex interplay of T cell developmental stages, as a consequence of the heterogeneity and specific expression of members of the Notch receptor family and their cognate ligands, in distinct thymic cell compartments. |
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| Keywords |
Animals; Basic Helix-Loop-Helix Transcription Factors; Calcium-Binding Proteins; Carrier Proteins/biosynthesis; Carrier Proteins/metabolism; Carrier Proteins/physiology; Cell Differentiation/immunology; DNA-Binding Proteins/biosynthesis; Helix-Loop-Helix Motifs; Homeodomain Proteins/biosynthesis; Intercellular Signaling Peptides and Proteins; Ligands; Lymphoid Tissue/cytology; Lymphoid Tissue/metabolism; Male; Membrane Proteins/biosynthesis; Membrane Proteins/metabolism; Membrane Proteins/physiology; Mice; Mice, Inbred C57BL; Protein Biosynthesis; Proteins/metabolism; Proteins/physiology; Proto-Oncogene Proteins/biosynthesis; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins/physiology; RNA, Messenger/biosynthesis; RNA, Messenger/metabolism; Receptor, Notch1; Receptor, Notch2; Receptors, Cell Surface/biosynthesis; Receptors, Cell Surface/metabolism; Receptors, Cell Surface/physiology; Receptors, Notch; Repressor Proteins/biosynthesis; Signal Transduction/immunology; Stromal Cells/metabolism; T-Lymphocyte Subsets/cytology; T-Lymphocytes/cytology; T-Lymphocytes/metabolism; Thymus Gland/cytology; Thymus Gland/metabolism; Transcription Factors |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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References
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