MOUSE:IZUM1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Izumo1
Protein Name(s)	Izumo sperm-egg fusion protein 1 Oocyte binding/fusion factor OBF Sperm-specific protein izumo
External Links
UniProt	Q9D9J7
EMBL	AB195681 AK006830
CCDS	CCDS21255.1
RefSeq	NP_001018013.1
UniGene	Mm.380445
ProteinModelPortal	Q9D9J7
STRING	10090.ENSMUSP00000033100
PhosphoSite	Q9D9J7
MaxQB	Q9D9J7
PaxDb	Q9D9J7
PRIDE	Q9D9J7
DNASU	73456
Ensembl	ENSMUST00000033100
GeneID	73456
KEGG	mmu:73456
UCSC	uc009gwh.1
CTD	284359
MGI	MGI:1920706
eggNOG	NOG41344
GeneTree	ENSGT00390000015014
HOGENOM	HOG000113123
HOVERGEN	HBG081813
InParanoid	Q9D9J7
OMA	TYRCELG
OrthoDB	EOG72ZCG1
PhylomeDB	Q9D9J7
TreeFam	TF338356
Reactome	REACT_199081
NextBio	338309
PRO	PR:Q9D9J7
Proteomes	UP000000589
Bgee	Q9D9J7
CleanEx	MM_IZUMO1
Genevestigator	Q9D9J7
GO	GO:0002080 GO:0001669 GO:0016021 GO:0042803 GO:0005102 GO:0007155 GO:0007342 GO:0007338 GO:0035036
InterPro	IPR003599 IPR029389
Pfam	PF15005
SMART	SM00409

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0007342	fusion of sperm to egg plasma membrane	PMID:15759005^[1]	ECO:0000315			P		Figure 3 shows male infertility when Izumo gene is disrupted with insertional mutagensis	complete CACAO 4933
part_of	GO:0005886	plasma membrane	PMID:27624483^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0002080	acrosomal membrane	PMID:27624483^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:27309808^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034113	heterotypic cell-cell adhesion	PMID:27309808^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0086080	protein binding involved in heterotypic cell-cell adhesion	PMID:27309808^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:15759005^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization	PMID:15759005^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:15759005^[1]	ECO:0000305	curator inference used in manual assertion	GO:0007342	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:19658160^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035036	sperm-egg recognition	PMID:24739963^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization	PMID:24739963^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007338	single fertilization	PMID:24739963^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:24739963^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9EQF4	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1565454	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IYV9	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IYV9	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IYV9	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IYV9	F		Seeded From UniProt	complete
part_of	GO:0002080	acrosomal membrane	PMID:20375058^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000018)	Seeded From UniProt	complete
part_of	GO:0002080	acrosomal membrane	PMID:19144954^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
part_of	GO:0001669	acrosomal vesicle	PMID:20421979^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032700	F		Seeded From UniProt	complete
involved_in	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032700	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032700	C		Seeded From UniProt	complete
involved_in	GO:0035036	sperm-egg recognition	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032700	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007338	single fertilization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0278	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0002080	acrosomal membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0006	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Inoue, N et al. (2005) The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature 434 234-8 PubMed GONUTS page
↑ ^2.0 ^2.1 Young, SA et al. (2016) CRISPR/Cas9-mediated mutation revealed cytoplasmic tail is dispensable for IZUMO1 function and male fertility. Reproduction 152 665-672 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Ohto, U et al. (2016) Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization. Nature 534 566-9 PubMed GONUTS page
↑ Ellerman, DA et al. (2009) Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. Mol. Reprod. Dev. 76 1188-99 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Bianchi, E et al. (2014) Juno is the egg Izumo receptor and is essential for mammalian fertilization. Nature 508 483-7 PubMed GONUTS page
↑ Fujihara, Y et al. (2010) Sperm equatorial segment protein 1, SPESP1, is required for fully fertile sperm in mouse. J. Cell. Sci. 123 1531-6 PubMed GONUTS page
↑ Miranda, PV et al. (2009) Localization of low-density detergent-resistant membrane proteins in intact and acrosome-reacted mouse sperm. Biol. Reprod. 80 897-904 PubMed GONUTS page
↑ Inoue, N et al. (2010) Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse. PLoS ONE 5 e10301 PubMed GONUTS page

[PMID:15759005-1] 1.0 ^1.1 ^1.2 ^1.3 Inoue, N et al. (2005) The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature 434 234-8 PubMed GONUTS page

[PMID:27624483-2] 2.0 ^2.1 Young, SA et al. (2016) CRISPR/Cas9-mediated mutation revealed cytoplasmic tail is dispensable for IZUMO1 function and male fertility. Reproduction 152 665-672 PubMed GONUTS page

[PMID:27309808-3] 3.0 ^3.1 ^3.2 Ohto, U et al. (2016) Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization. Nature 534 566-9 PubMed GONUTS page

[PMID:19658160-4] Ellerman, DA et al. (2009) Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. Mol. Reprod. Dev. 76 1188-99 PubMed GONUTS page

[PMID:24739963-5] 5.0 ^5.1 ^5.2 ^5.3 Bianchi, E et al. (2014) Juno is the egg Izumo receptor and is essential for mammalian fertilization. Nature 508 483-7 PubMed GONUTS page

[PMID:20375058-6] Fujihara, Y et al. (2010) Sperm equatorial segment protein 1, SPESP1, is required for fully fertile sperm in mouse. J. Cell. Sci. 123 1531-6 PubMed GONUTS page

[PMID:19144954-7] Miranda, PV et al. (2009) Localization of low-density detergent-resistant membrane proteins in intact and acrosome-reacted mouse sperm. Biol. Reprod. 80 897-904 PubMed GONUTS page

[PMID:20421979-8] Inoue, N et al. (2010) Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse. PLoS ONE 5 e10301 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

MOUSE:IZUM1

Contents

Annotations

Notes

References

a

c

e

f

g

h

i

m

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools