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MOUSE:ITK

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Itk (synonyms: Emt, Tlk, Tsk)
Protein Name(s) Tyrosine-protein kinase ITK/TSK

IL-2-inducible T-cell kinase Kinase EMT Kinase TLK T-cell-specific kinase

External Links
UniProt Q03526
EMBL L00619
L05631
L10628
D14042
CCDS CCDS70169.1
PIR A43030
RefSeq NP_001268894.1
NP_001268895.1
NP_001268897.1
NP_034713.2
UniGene Mm.339927
PDB 1AWJ
1LUI
1LUK
1LUM
1LUN
2ETZ
2EU0
2K79
2K7A
2RN8
2RNA
3S9K
PDBsum 1AWJ
1LUI
1LUK
1LUM
1LUN
2ETZ
2EU0
2K79
2K7A
2RN8
2RNA
3S9K
ProteinModelPortal Q03526
SMR Q03526
BioGrid 200840
DIP DIP-29283N
IntAct Q03526
MINT MINT-84965
PhosphoSite Q03526
PRIDE Q03526
Ensembl ENSMUST00000109237
GeneID 16428
KEGG mmu:16428
UCSC uc011xtn.1
CTD 3702
MGI MGI:96621
eggNOG COG0515
GeneTree ENSGT00760000119011
HOGENOM HOG000233859
HOVERGEN HBG008761
InParanoid Q03526
KO K07363
OMA HVYQIMN
PhylomeDB Q03526
TreeFam TF351634
BRENDA 2.7.10.1
Reactome REACT_188202
REACT_225768
EvolutionaryTrace Q03526
NextBio 289653
PRO PR:Q03526
Proteomes UP000000589
Bgee Q03526
CleanEx MM_ITK
ExpressionAtlas Q03526
Genevestigator Q03526
GO GO:0005911
GO:0005829
GO:0005524
GO:0046872
GO:0004715
GO:0007202
GO:0002250
GO:0001816
GO:0032609
GO:0032633
GO:0035556
GO:0001865
GO:0018108
GO:0050852
Gene3D 2.30.29.30
3.30.505.10
InterPro IPR011009
IPR001849
IPR011993
IPR000719
IPR017441
IPR001245
IPR000980
IPR001452
IPR008266
IPR020635
IPR001562
Pfam PF00779
PF00169
PF07714
PF00017
PF00018
PRINTS PR00401
PR00402
PR00109
SMART SM00107
SM00233
SM00252
SM00326
SM00219
SUPFAM SSF50044
SSF55550
SSF56112
PROSITE PS50003
PS00107
PS50011
PS00109
PS50001
PS50002
PS51113

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006468

protein phosphorylation

PMID:15662016[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15662016[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050852

T cell receptor signaling pathway

PMID:10213685[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007202

activation of phospholipase C activity

PMID:10213685[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q08881

F

Seeded From UniProt

complete

involved_in

GO:0002250

adaptive immune response

PMID:10213685[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001816

cytokine production

PMID:10213685[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050853

B cell receptor signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000700360
UniProtKB:P42680

P

Seeded From UniProt

complete

involved_in

GO:0050852

T cell receptor signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102960
MGI:MGI:96621
PANTHER:PTN000700360

P

Seeded From UniProt

complete

involved_in

GO:0038083

peptidyl-tyrosine autophosphorylation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001231474
UniProtKB:P42680

P

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001231474
UniProtKB:P42680
UniProtKB:P51813
UniProtKB:Q08881

F

Seeded From UniProt

complete

involved_in

GO:0002250

adaptive immune response

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102960
MGI:MGI:96621
PANTHER:PTN000700360

P

Seeded From UniProt

complete

involved_in

GO:0001865

NK T cell differentiation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96621
PANTHER:PTN001231477

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032633

interleukin-4 production

PMID:18292523[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:102960

P

occurs_in:(EMAPA:18767)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032633

interleukin-4 production

PMID:18292523[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2178928

P

occurs_in:(EMAPA:18767)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032609

interferon-gamma production

PMID:18292523[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:102960

P

occurs_in:(EMAPA:18767)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032609

interferon-gamma production

PMID:18292523[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2178928

P

occurs_in:(EMAPA:18767)

Seeded From UniProt

complete

part_of

GO:0005911

cell-cell junction

PMID:23793062[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q08881

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001865

NK T cell differentiation

PMID:18292523[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:102960

P

occurs_in:(EMAPA:18767)|occurs_in:(EMAPA:18768)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001865

NK T cell differentiation

PMID:18292523[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2178928

P

occurs_in:(EMAPA:18767)|occurs_in:(EMAPA:18768)

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q08881
ensembl:ENSP00000398655

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020635

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266
InterPro:IPR020635

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001562

P

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.10.2

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-MMU-2730850

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

involved_in

GO:0002250

adaptive immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1064

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Hwang, ES et al. (2005) T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 307 430-3 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Schaeffer, EM et al. (1999) Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science 284 638-41 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Felices, M & Berg, LJ (2008) The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival. J. Immunol. 180 3007-18 PubMed GONUTS page
  5. ↑ Liang, Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat. Immunol. 14 858-66 PubMed GONUTS page
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