MOUSE:IMB1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Kpnb1 (synonyms: Impnb)
Protein Name(s)	Importin subunit beta-1 Karyopherin subunit beta-1 Nuclear factor p97 Pore targeting complex 97 kDa subunit PTAC97 SCG
External Links
UniProt	P70168
EMBL	D67015 D45836 AL627445 CH466556 BC052438 BC055115
CCDS	CCDS25316.1
PIR	S66288
RefSeq	NP_032405.3
UniGene	Mm.251013
PDB	1GCJ 1UKL
PDBsum	1GCJ 1UKL
ProteinModelPortal	P70168
SMR	P70168
BioGrid	200654
DIP	DIP-33404N
IntAct	P70168
MINT	MINT-6478527
PhosphoSite	P70168
MaxQB	P70168
PaxDb	P70168
PRIDE	P70168
Ensembl	ENSMUST00000001479
GeneID	16211
KEGG	mmu:16211
UCSC	uc007ldu.1
CTD	3837
MGI	MGI:107532
eggNOG	COG5215
GeneTree	ENSGT00550000074898
HOGENOM	HOG000204108
HOVERGEN	HBG002369
InParanoid	P70168
KO	K14293
OMA	MSNILPY
OrthoDB	EOG7GN2KZ
TreeFam	TF105655
Reactome	REACT_198968 REACT_205002
ChiTaRS	Kpnb1
EvolutionaryTrace	P70168
NextBio	289169
PRO	PR:P70168
Proteomes	UP000000589
Bgee	P70168
CleanEx	MM_KPNB1
ExpressionAtlas	P70168
Genevestigator	P70168
GO	GO:0005737 GO:0071782 GO:0070062 GO:0016020 GO:0005635 GO:0031965 GO:0005634 GO:0043234 GO:0019899 GO:0044822 GO:0019904 GO:0008565 GO:0006606 GO:0006610
Gene3D	1.25.10.10
InterPro	IPR011989 IPR016024 IPR021133 IPR001494 IPR027140
PANTHER	PTHR10527:SF1
Pfam	PF03810
SMART	SM00913
SUPFAM	SSF48371
PROSITE	PS50077 PS50166

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0010494	cytoplasmic stress granule	PMID:27430620^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034599)	Seeded From UniProt	complete
part_of	GO:0034399	nuclear periphery	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000055427 PomBase:SPAC1B1.03c PomBase:SPAC2F3.06c PomBase:SPBC14F5.03c PomBase:SPCC1840.03	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000055427 UniProtKB:Q14974	C		Seeded From UniProt	complete
enables	GO:0008565	obsolete protein transporter activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107532 MGI:MGI:1917822 PANTHER:PTN000055427 SGD:S000000912 SGD:S000004339 SGD:S000004925 TAIR:locus:2039410 TAIR:locus:2168586	F		Seeded From UniProt	complete
enables	GO:0008139	nuclear localization sequence binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000055427 SGD:S000000221 SGD:S000000912 SGD:S000004925	F		Seeded From UniProt	complete
involved_in	GO:0006610	ribosomal protein import into nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107532 PANTHER:PTN000055427 UniProtKB:O00410 UniProtKB:Q14974	P		Seeded From UniProt	complete
involved_in	GO:0006607	NLS-bearing protein import into nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0262743 MGI:MGI:1917822 PANTHER:PTN000055427 SGD:S000000912 UniProtKB:Q8I3M5	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0262743 MGI:MGI:1917822 PANTHER:PTN000055427 PomBase:SPCC1840.03 SGD:S000000912 SGD:S000004339 SGD:S000004925 TAIR:locus:2039410 TAIR:locus:2168586 UniProtKB:G5EAZ4	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090307	mitotic spindle assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	P		Seeded From UniProt	complete
part_of	GO:0071782	endoplasmic reticulum tubular network	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	C		Seeded From UniProt	complete
enables	GO:0061676	importin-alpha family protein binding	PMID:20699224^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P52293	F		Seeded From UniProt	complete
enables	GO:0061676	importin-alpha family protein binding	PMID:20699224^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:C0LLJ0	F		Seeded From UniProt	complete
enables	GO:0061608	nuclear import signal receptor activity	PMID:15689618^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0061608	nuclear import signal receptor activity	PMID:11809816^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	PMID:19581287^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0002320)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045184	establishment of protein localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2909	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040001	establishment of mitotic spindle localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:19796622^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031291	Ran protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030953	astral microtubule organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	F		Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2909	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007080	mitotic metaphase plate congression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007079	mitotic chromosome movement towards spindle pole	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006610	ribosomal protein import into nucleus	PMID:11809816^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006610	ribosomal protein import into nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006606	protein import into nucleus	PMID:15689618^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006606	protein import into nucleus	PMID:15964792^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006606	protein import into nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	C		Seeded From UniProt	complete
part_of	GO:0005643	nuclear pore	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2909	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q14974	C		Seeded From UniProt	complete
involved_in	GO:0090307	mitotic spindle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14974 ensembl:ENSP00000290158	P		Seeded From UniProt	complete
part_of	GO:0071782	endoplasmic reticulum tubular network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14974 ensembl:ENSP00000290158	C		Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14974 ensembl:ENSP00000290158	P		Seeded From UniProt	complete
involved_in	GO:0040001	establishment of mitotic spindle localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14974 ensembl:ENSP00000290158	P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14974 ensembl:ENSP00000290158	C		Seeded From UniProt	complete
involved_in	GO:0031291	Ran protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14974 ensembl:ENSP00000290158	P		Seeded From UniProt	complete
involved_in	GO:0030953	astral microtubule organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14974 ensembl:ENSP00000290158	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14974 ensembl:ENSP00000290158	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14974 ensembl:ENSP00000290158	F		Seeded From UniProt	complete
involved_in	GO:0007080	mitotic metaphase plate congression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14974 ensembl:ENSP00000290158	P		Seeded From UniProt	complete
involved_in	GO:0007079	mitotic chromosome movement towards spindle pole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14974 ensembl:ENSP00000290158	P		Seeded From UniProt	complete
involved_in	GO:0006610	ribosomal protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14974 ensembl:ENSP00000290158	P		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14974 ensembl:ENSP00000290158	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14974 ensembl:ENSP00000290158	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14974 ensembl:ENSP00000290158	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q14974 ensembl:ENSP00000290158	C		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040122	P		Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001494	P		Seeded From UniProt	complete
enables	GO:0008536	Ran GTPase binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001494	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0178	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Mahboubi, H et al. (2016) AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization. Mol. Pharmacol. 90 460-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Hu, J et al. (2010) Novel importin-alpha family member Kpna7 is required for normal fertility and fecundity in the mouse. J. Biol. Chem. 285 33113-22 PubMed GONUTS page
↑ ^4.0 ^4.1 Sakakida, Y et al. (2005) Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal. J. Biol. Chem. 280 13272-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Plafker, SM & Macara, IG (2002) Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11. Mol. Cell. Biol. 22 1266-75 PubMed GONUTS page
↑ Echeverría, PC et al. (2009) Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta. Mol. Cell. Biol. 29 4788-97 PubMed GONUTS page
↑ Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
↑ Kahle, J et al. (2005) Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13. Mol. Cell. Biol. 25 5339-54 PubMed GONUTS page

[PMID:27430620-1] Mahboubi, H et al. (2016) AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization. Mol. Pharmacol. 90 460-8 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20699224-3] 3.0 ^3.1 Hu, J et al. (2010) Novel importin-alpha family member Kpna7 is required for normal fertility and fecundity in the mouse. J. Biol. Chem. 285 33113-22 PubMed GONUTS page

[PMID:15689618-4] 4.0 ^4.1 Sakakida, Y et al. (2005) Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal. J. Biol. Chem. 280 13272-8 PubMed GONUTS page

[PMID:11809816-5] 5.0 ^5.1 Plafker, SM & Macara, IG (2002) Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11. Mol. Cell. Biol. 22 1266-75 PubMed GONUTS page

[PMID:19581287-6] Echeverría, PC et al. (2009) Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta. Mol. Cell. Biol. 29 4788-97 PubMed GONUTS page

[PMID:19796622-7] Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page

[PMID:15964792-8] Kahle, J et al. (2005) Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13. Mol. Cell. Biol. 25 5339-54 PubMed GONUTS page

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MOUSE:IMB1

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References

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