MOUSE:IL3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Il3 (synonyms: Csfmu, Il-3)
Protein Name(s)	Interleukin-3 IL-3 Hematopoietic growth factor Mast cell growth factor MCGF Multipotential colony-stimulating factor P-cell-stimulating factor
External Links
UniProt	P01586
EMBL	K01850 K01668 K03233 X02732 M20128 M14394
CCDS	CCDS24693.1
PIR	A25481
RefSeq	NP_034686.2
UniGene	Mm.983
PDB	2L3O
PDBsum	2L3O
ProteinModelPortal	P01586
SMR	P01586
PhosphoSite	P01586
PRIDE	P01586
Ensembl	ENSMUST00000019058
GeneID	16187
KEGG	mmu:16187
UCSC	uc007ixn.1
CTD	3562
MGI	MGI:96552
eggNOG	opiNOG27251
HOGENOM	HOG000113051
HOVERGEN	HBG006148
InParanoid	P01586
KO	K04736
OMA	SGRDTHR
OrthoDB	EOG7BZVW6
PhylomeDB	P01586
TreeFam	TF338567
NextBio	289085
PRO	PR:P01586
Proteomes	UP000000589
Bgee	P01586
CleanEx	MM_IL3
ExpressionAtlas	P01586
Genevestigator	P01586
GO	GO:0005615 GO:0005125 GO:0008083 GO:0019221 GO:0097192 GO:0006955 GO:0033028 GO:0043066 GO:0010507 GO:0033026 GO:0008284 GO:0046330 GO:0070668 GO:0002763 GO:0050731 GO:0001934 GO:0010468 GO:0006110 GO:0035304 GO:0001666
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR002183
PANTHER	PTHR10079
Pfam	PF02059
PIRSF	PIRSF001939
PRINTS	PR00430
SUPFAM	SSF47266

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:15680329^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:15231831^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:14967141^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000826)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:12944463^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:12124386^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:11527400^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070668	positive regulation of mast cell proliferation	PMID:15947484^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070668	positive regulation of mast cell proliferation	PMID:12714518^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:7519779^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:10872802^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000236)\|regulates_o_occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	PMID:14967141^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000826)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	PMID:14967141^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000826)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:7736574^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:10652277^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000557)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042976	activation of Janus kinase activity	PMID:8378315^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038156	interleukin-3-mediated signaling pathway	PMID:19109256^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035304	regulation of protein dephosphorylation	PMID:12944463^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_has_input:(MGI:MGI:1096330)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033028	myeloid cell apoptotic process	PMID:9202146^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000763)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033026	negative regulation of mast cell apoptotic process	PMID:12714518^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030224	monocyte differentiation	PMID:19109256^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96553	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030097	hemopoiesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2897	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019221	cytokine-mediated signaling pathway	PMID:7519779^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010507	negative regulation of autophagy	PMID:15680329^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:9697835^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:32760) occurs_in:(CL:0000049) has_regulation_target:(MGI:MGI:95484)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009725	response to hormone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2897	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:7690439^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:7957045^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:7736574^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:1350248^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2897	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:7957045^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000826)	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:12714518^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006110	regulation of glycolytic process	PMID:17437992^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:106918	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:7690439^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2897	C		Seeded From UniProt	complete
enables	GO:0005135	interleukin-3 receptor binding	PMID:19109256^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P26952-3	F		Seeded From UniProt	complete
enables	GO:0005135	interleukin-3 receptor binding	PMID:19109256^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P26952-1	F		Seeded From UniProt	complete
enables	GO:0005135	interleukin-3 receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2897	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:7957045^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000826)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:7736574^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000236)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:7519779^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:14967141^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000826)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:1350248^[19]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000839)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:12714518^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000097)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:10872802^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000236)\|occurs_in:(CL:0000097)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:10652277^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000557)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2897	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002763	positive regulation of myeloid leukocyte differentiation	PMID:7690439^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96974	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000837)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002763	positive regulation of myeloid leukocyte differentiation	PMID:1375116^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96974	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000837)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	PMID:14967141^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000826)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:17437992^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:106918	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001558	regulation of cell growth	PMID:19109256^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96553	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001558	regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2897	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
enables	GO:0005135	interleukin-3 receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002183	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002183	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002183	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002183	F		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Lum, JJ et al. (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120 237-48 PubMed GONUTS page
↑ Seo, SY et al. (2004) BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J. Biol. Chem. 279 42240-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Yu, C et al. (2004) JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol. Cell 13 329-40 PubMed GONUTS page
↑ ^4.0 ^4.1 Chiang, CW et al. (2003) Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Mol. Cell. Biol. 23 6350-62 PubMed GONUTS page
↑ Xu, J et al. (2002) The role of Asp-462 in regulating Akt activity. J. Biol. Chem. 277 35561-6 PubMed GONUTS page
↑ Antoku, K et al. (2001) Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein. Biochem. Biophys. Res. Commun. 286 1003-10 PubMed GONUTS page
↑ Ikeda, K et al. (2005) Stat5a is essential for the proliferation and survival of murine mast cells. Int. Arch. Allergy Immunol. 137 Suppl 1 45-50 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Shelburne, CP et al. (2003) Stat5 expression is critical for mast cell development and survival. Blood 102 1290-7 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Ito, T et al. (1994) Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase. Proc. Natl. Acad. Sci. U.S.A. 91 7455-9 PubMed GONUTS page
↑ ^10.0 ^10.1 Iseki, M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem. Biophys. Res. Commun. 272 45-54 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Miyazaki, T et al. (1995) Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81 223-31 PubMed GONUTS page
↑ ^12.0 ^12.1 Kieslinger, M et al. (2000) Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. Genes Dev. 14 232-44 PubMed GONUTS page
↑ Silvennoinen, O et al. (1993) Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. Proc. Natl. Acad. Sci. U.S.A. 90 8429-33 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 Chen, J et al. (2009) A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode. J. Biol. Chem. 284 5763-73 PubMed GONUTS page
↑ Barge, RM et al. (1997) Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal. FEBS Lett. 409 207-10 PubMed GONUTS page
↑ Traver, D et al. (1998) Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Immunity 9 47-57 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Ploemacher, RE et al. (1993) Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor. Leukemia 7 1374-80 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Hilton, DJ et al. (1994) Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J. 13 4765-75 PubMed GONUTS page
↑ ^19.0 ^19.1 Okada, S et al. (1992) Synergistic effect of IL-3 and IL-6 on highly enriched murine hemopoietic progenitors. Exp. Hematol. 20 546-51 PubMed GONUTS page
↑ ^20.0 ^20.1 Lum, JJ et al. (2007) The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev. 21 1037-49 PubMed GONUTS page
↑ Tsuji, K et al. (1992) Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture. Blood 79 2855-60 PubMed GONUTS page

[PMID:15680329-1] 1.0 ^1.1 Lum, JJ et al. (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120 237-48 PubMed GONUTS page

[PMID:15231831-2] Seo, SY et al. (2004) BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J. Biol. Chem. 279 42240-9 PubMed GONUTS page

[PMID:14967141-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Yu, C et al. (2004) JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol. Cell 13 329-40 PubMed GONUTS page

[PMID:12944463-4] 4.0 ^4.1 Chiang, CW et al. (2003) Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Mol. Cell. Biol. 23 6350-62 PubMed GONUTS page

[PMID:12124386-5] Xu, J et al. (2002) The role of Asp-462 in regulating Akt activity. J. Biol. Chem. 277 35561-6 PubMed GONUTS page

[PMID:11527400-6] Antoku, K et al. (2001) Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein. Biochem. Biophys. Res. Commun. 286 1003-10 PubMed GONUTS page

[PMID:15947484-7] Ikeda, K et al. (2005) Stat5a is essential for the proliferation and survival of murine mast cells. Int. Arch. Allergy Immunol. 137 Suppl 1 45-50 PubMed GONUTS page

[PMID:12714518-8] 8.0 ^8.1 ^8.2 ^8.3 Shelburne, CP et al. (2003) Stat5 expression is critical for mast cell development and survival. Blood 102 1290-7 PubMed GONUTS page

[PMID:7519779-9] 9.0 ^9.1 ^9.2 Ito, T et al. (1994) Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase. Proc. Natl. Acad. Sci. U.S.A. 91 7455-9 PubMed GONUTS page

[PMID:10872802-10] 10.0 ^10.1 Iseki, M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem. Biophys. Res. Commun. 272 45-54 PubMed GONUTS page

[PMID:7736574-11] 11.0 ^11.1 ^11.2 Miyazaki, T et al. (1995) Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81 223-31 PubMed GONUTS page

[PMID:10652277-12] 12.0 ^12.1 Kieslinger, M et al. (2000) Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. Genes Dev. 14 232-44 PubMed GONUTS page

[PMID:8378315-13] Silvennoinen, O et al. (1993) Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. Proc. Natl. Acad. Sci. U.S.A. 90 8429-33 PubMed GONUTS page

[PMID:19109256-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 Chen, J et al. (2009) A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode. J. Biol. Chem. 284 5763-73 PubMed GONUTS page

[PMID:9202146-15] Barge, RM et al. (1997) Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal. FEBS Lett. 409 207-10 PubMed GONUTS page

[PMID:9697835-16] Traver, D et al. (1998) Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Immunity 9 47-57 PubMed GONUTS page

[PMID:7690439-17] 17.0 ^17.1 ^17.2 Ploemacher, RE et al. (1993) Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor. Leukemia 7 1374-80 PubMed GONUTS page

[PMID:7957045-18] 18.0 ^18.1 ^18.2 Hilton, DJ et al. (1994) Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J. 13 4765-75 PubMed GONUTS page

[PMID:1350248-19] 19.0 ^19.1 Okada, S et al. (1992) Synergistic effect of IL-3 and IL-6 on highly enriched murine hemopoietic progenitors. Exp. Hematol. 20 546-51 PubMed GONUTS page

[PMID:17437992-20] 20.0 ^20.1 Lum, JJ et al. (2007) The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev. 21 1037-49 PubMed GONUTS page

[PMID:1375116-21] Tsuji, K et al. (1992) Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture. Blood 79 2855-60 PubMed GONUTS page

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MOUSE:IL3

Contents

Annotations

Notes

References

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