MOUSE:IFT57

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ift57 (synonyms: Hippi)
Protein Name(s)	Intraflagellar transport protein 57 homolog HIP1-interacting protein
External Links
UniProt	Q8BXG3
EMBL	AF274590 DQ266091 AK014731 AK047217
CCDS	CCDS28211.1
RefSeq	NP_082956.2
UniGene	Mm.241276 Mm.404371
ProteinModelPortal	Q8BXG3
BioGrid	216353
PhosphoSite	Q8BXG3
MaxQB	Q8BXG3
PaxDb	Q8BXG3
PRIDE	Q8BXG3
Ensembl	ENSMUST00000046777 ENSMUST00000142682
GeneID	73916
KEGG	mmu:73916
UCSC	uc007zkf.1
CTD	55081
MGI	MGI:1921166
eggNOG	NOG263230
GeneTree	ENSGT00390000006307
HOGENOM	HOG000007186
HOVERGEN	HBG054573
InParanoid	Q8BXG3
KO	K04638
OMA	FTWKRPT
OrthoDB	EOG75B85X
PhylomeDB	Q8BXG3
TreeFam	TF106156
Reactome	REACT_269412
NextBio	339338
PRO	PR:Q8BXG3
Proteomes	UP000000589
Bgee	Q8BXG3
ExpressionAtlas	Q8BXG3
Genevestigator	Q8BXG3
GO	GO:0005813 GO:0036064 GO:0005929 GO:0044292 GO:0005794 GO:0030992 GO:0032391 GO:0072372 GO:0003677 GO:0006919 GO:0006915 GO:0042384 GO:0060271 GO:0001947 GO:0042073 GO:0060972 GO:0050680 GO:0001843 GO:0042981 GO:0006355 GO:0007224 GO:0006351
InterPro	IPR019530
PANTHER	PTHR16011
Pfam	PF10498

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005930	axoneme	PMID:21209331^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Fig 3 D shows axenomal localisation in WT	complete CACAO 2903
part_of	GO:0005930	axoneme	PMID:21209331^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030992	intraciliary transport particle B	PMID:25443296^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030992	intraciliary transport particle B	PMID:24596149^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21209331^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:17931679^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042073	intraciliary transport	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000410691 ZFIN:ZDB-GENE-040614-1	P		Seeded From UniProt	complete
part_of	GO:0030992	intraciliary transport particle B	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1921166 PANTHER:PTN000410691 WB:WBGene00000492	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1921166 PANTHER:PTN000410691	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1921166 PANTHER:PTN000410691	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1921166 PANTHER:PTN000410691	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905515	non-motile cilium assembly	PMID:21703454^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000312)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060972	left/right pattern formation	PMID:17027958^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3707373	P	occurs_in:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	PMID:21703454^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044458	motile cilium assembly	PMID:17027958^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3707373	P	occurs_in:(EMAPA:16075)	Seeded From UniProt	complete
part_of	GO:0044292	dendrite terminus	PMID:20368623^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17168) part_of:(CL:0000745)\|part_of:(EMAPA:17168) part_of:(CL:0000748)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	PMID:11788820^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NWB7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042073	intraciliary transport	PMID:19253336^[10]	ECO:0000305	curator inference used in manual assertion	GO:0030992	P		Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:23955340^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	PMID:22922713^[12]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q93833	C		Seeded From UniProt	complete
part_of	GO:0032391	photoreceptor connecting cilium	PMID:20368623^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35686) part_of:(CL:0000210)	Seeded From UniProt	complete
part_of	GO:0030992	intraciliary transport particle B	PMID:23810713^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000437)	Seeded From UniProt	complete
part_of	GO:0030992	intraciliary transport particle B	PMID:19253336^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030992	intraciliary transport particle B	PMID:12821668^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17168)\|part_of:(EMAPA:17373)\|part_of:(EMAPA:17972)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:17027958^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3707373	P	occurs_in:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:11788820^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NWB7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	PMID:11788820^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NWB7	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:19253336^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:19253336^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:11788820^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001947	heart looping	PMID:17027958^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3707373	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001843	neural tube closure	PMID:17027958^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3707373	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NWB7 ensembl:ENSP00000264538	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NWB7 ensembl:ENSP00000264538	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NWB7 ensembl:ENSP00000264538	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	Reactome:R-MMU-5617824	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page
↑ Liew, GM et al. (2014) The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3. Dev. Cell 31 265-78 PubMed GONUTS page
↑ Ishikawa, H et al. (2014) TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. Elife 3 e01566 PubMed GONUTS page
↑ Luby-Phelps, K et al. (2008) Spatial distribution of intraflagellar transport proteins in vertebrate photoreceptors. Vision Res. 48 413-23 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 Ezratty, EJ et al. (2011) A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell 145 1129-41 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Houde, C et al. (2006) Hippi is essential for node cilia assembly and Sonic hedgehog signaling. Dev. Biol. 300 523-33 PubMed GONUTS page
↑ ^8.0 ^8.1 Sedmak, T & Wolfrum, U (2010) Intraflagellar transport molecules in ciliary and nonciliary cells of the retina. J. Cell Biol. 189 171-86 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Gervais, FG et al. (2002) Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi. Nat. Cell Biol. 4 95-105 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Follit, JA et al. (2009) Characterization of mouse IFT complex B. Cell Motil. Cytoskeleton 66 457-68 PubMed GONUTS page
↑ Wang, C et al. (2013) Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. J. Biol. Chem. 288 29518-29 PubMed GONUTS page
↑ Wei, Q et al. (2012) The BBSome controls IFT assembly and turnaround in cilia. Nat. Cell Biol. 14 950-7 PubMed GONUTS page
↑ Howard, PW et al. (2013) Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17. Exp. Cell Res. 319 2275-81 PubMed GONUTS page
↑ Baker, SA et al. (2003) IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia. J. Biol. Chem. 278 34211-8 PubMed GONUTS page

[PMID:21209331-1] 1.0 ^1.1 ^1.2 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page

[PMID:25443296-2] Liew, GM et al. (2014) The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3. Dev. Cell 31 265-78 PubMed GONUTS page

[PMID:24596149-3] Ishikawa, H et al. (2014) TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. Elife 3 e01566 PubMed GONUTS page

[PMID:17931679-4] Luby-Phelps, K et al. (2008) Spatial distribution of intraflagellar transport proteins in vertebrate photoreceptors. Vision Res. 48 413-23 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21703454-6] 6.0 ^6.1 Ezratty, EJ et al. (2011) A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell 145 1129-41 PubMed GONUTS page

[PMID:17027958-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Houde, C et al. (2006) Hippi is essential for node cilia assembly and Sonic hedgehog signaling. Dev. Biol. 300 523-33 PubMed GONUTS page

[PMID:20368623-8] 8.0 ^8.1 Sedmak, T & Wolfrum, U (2010) Intraflagellar transport molecules in ciliary and nonciliary cells of the retina. J. Cell Biol. 189 171-86 PubMed GONUTS page

[PMID:11788820-9] 9.0 ^9.1 ^9.2 ^9.3 Gervais, FG et al. (2002) Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi. Nat. Cell Biol. 4 95-105 PubMed GONUTS page

[PMID:19253336-10] 10.0 ^10.1 ^10.2 ^10.3 Follit, JA et al. (2009) Characterization of mouse IFT complex B. Cell Motil. Cytoskeleton 66 457-68 PubMed GONUTS page

[PMID:23955340-11] Wang, C et al. (2013) Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. J. Biol. Chem. 288 29518-29 PubMed GONUTS page

[PMID:22922713-12] Wei, Q et al. (2012) The BBSome controls IFT assembly and turnaround in cilia. Nat. Cell Biol. 14 950-7 PubMed GONUTS page

[PMID:23810713-13] Howard, PW et al. (2013) Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17. Exp. Cell Res. 319 2275-81 PubMed GONUTS page

[PMID:12821668-14] Baker, SA et al. (2003) IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia. J. Biol. Chem. 278 34211-8 PubMed GONUTS page

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MOUSE:IFT57

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