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MOUSE:HXB1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Hoxb1 (synonyms: Hox-2.9, Hoxb-1)
Protein Name(s) Homeobox protein Hox-B1

Homeobox protein Hox-2.9

External Links
UniProt P17919
EMBL X53063
X59474
AK017686
BC103597
BC103598
BC103606
M34005
CCDS CCDS25300.1
PIR A60082
RefSeq NP_032292.3
UniGene Mm.890
ProteinModelPortal P17919
SMR P17919
BioGrid 200375
PhosphoSite P17919
PRIDE P17919
Ensembl ENSMUST00000019117
GeneID 15407
KEGG mmu:15407
UCSC uc007lbz.2
CTD 3211
MGI MGI:96182
eggNOG NOG236971
GeneTree ENSGT00760000118940
HOGENOM HOG000247020
HOVERGEN HBG006089
InParanoid P17919
KO K09301
OMA YAICNRG
OrthoDB EOG7PK91P
PhylomeDB P17919
TreeFam TF317730
NextBio 288120
PRO PR:P17919
Proteomes UP000000589
Bgee P17919
CleanEx MM_HOXB1
Genevestigator P17919
GO GO:0005634
GO:0003677
GO:0043565
GO:0048646
GO:0009653
GO:0009952
GO:0048704
GO:0021612
GO:0021754
GO:0045944
GO:0021570
GO:0021571
GO:0021546
GO:0006351
Gene3D 1.10.10.60
InterPro IPR017970
IPR001356
IPR020479
IPR009057
Pfam PF00046
PRINTS PR00024
SMART SM00389
SUPFAM SSF46689
PROSITE PS00027
PS50071

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

acts_upstream_of_or_within

GO:0048704

embryonic skeletal system morphogenesis

PMID:10885747[1]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96183
MGI:MGI:96184
MGI:MGI:96185
MGI:MGI:96186
MGI:MGI:96187
MGI:MGI:96188
MGI:MGI:96189
MGI:MGI:96190

P

has_participant:(EMAPA:19431)|has_participant:(EMAPA:19432)|has_participant:(EMAPA:19466)|has_participant:(EMAPA:19467)|has_participant:(EMAPA:19542)|has_participant:(EMAPA:19543)|has_participant:(EMAPA:19544)|has_participant:(EMAPA:19545)|has_participant:(EMAPA:19549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048646

anatomical structure formation involved in morphogenesis

PMID:10529420[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96170

P

results_in_formation_of:(EMAPA:16272)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:18787068[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14653

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:18787068[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97495

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021754

facial nucleus development

PMID:8898234[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857824

P

results_in_development_of:(EMAPA:35338)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021612

facial nerve structural organization

PMID:8898234[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857824

P

has_participant:(EMAPA:17796)|has_participant:(EMAPA:17264)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021571

rhombomere 5 development

PMID:10529420[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96170

P

results_in_development_of:(EMAPA:16496)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021570

rhombomere 4 development

PMID:10529420[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96170

P

results_in_development_of:(EMAPA:16492)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021546

rhombomere development

PMID:21320481[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14653

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009952

anterior/posterior pattern specification

PMID:10885747[1]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96183
MGI:MGI:96184
MGI:MGI:96185
MGI:MGI:96186
MGI:MGI:96187
MGI:MGI:96188
MGI:MGI:96189
MGI:MGI:96190

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009952

anterior/posterior pattern specification

PMID:10529420[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96170

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009653

anatomical structure morphogenesis

PMID:10529420[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96170

P

has_participant:(EMAPA:16399)

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:7911971[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14653

F

Seeded From UniProt

complete

contributes_to

GO:0003677

DNA binding

PMID:9242495[7]

ECO:0000314

direct assay evidence used in manual assertion

F

has_participant:(MGI:MGI:96183)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14653

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14653

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14653

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14653
ensembl:ENSP00000355140

P

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14653
ensembl:ENSP00000355140

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14653
ensembl:ENSP00000355140

F

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14653
ensembl:ENSP00000355140

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14653
ensembl:ENSP00000355140

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14653
ensembl:ENSP00000355140

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001356
InterPro:IPR009057
InterPro:IPR020479

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017970

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017970

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-MMU-5693628
Reactome:R-MMU-5621012
Reactome:R-MMU-5621004
Reactome:R-MMU-5619424
Reactome:R-MMU-5617982

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0371
UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Medina-Martínez, O et al. (2000) A large targeted deletion of Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations. Dev. Biol. 222 71-83 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Rossel, M & Capecchi, MR (1999) Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Development 126 5027-40 PubMed GONUTS page
  3. ↑ 3.0 3.1 Wassef, MA et al. (2008) Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors. Development 135 3369-78 PubMed GONUTS page
  4. ↑ 4.0 4.1 Goddard, JM et al. (1996) Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve. Development 122 3217-28 PubMed GONUTS page
  5. ↑ Wong, EY et al. (2011) Hoxb3 negatively regulates Hoxb1 expression in mouse hindbrain patterning. Dev. Biol. 352 382-92 PubMed GONUTS page
  6. ↑ Pellerin, I et al. (1994) Hox proteins have different affinities for a consensus DNA site that correlate with the positions of their genes on the hox cluster. Mol. Cell. Biol. 14 4532-45 PubMed GONUTS page
  7. ↑ Maconochie, MK et al. (1997) Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1. Genes Dev. 11 1885-95 PubMed GONUTS page
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