MOUSE:HXA1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Hoxa1 (synonyms: Era-1, Hox-1.6, Hoxa-1)
Protein Name(s)	Homeobox protein Hox-A1 Early retinoic acid 1 Homeobox protein Hox-1.6 Homeoboxless protein ERA-1-399 Homeotic protein ERA-1-993
External Links
UniProt	P09022
EMBL	M22115 M22115 X06023 X06024 M20214 M20216 M20215
PIR	A27155 A30242 B30242
UniGene	Mm.197
ProteinModelPortal	P09022
SMR	P09022
DIP	DIP-59869N
IntAct	P09022
PhosphoSite	P09022
PRIDE	P09022
MGI	MGI:96170
eggNOG	NOG236971
HOGENOM	HOG000171545
HOVERGEN	HBG006089
InParanoid	P09022
PRO	PR:P09022
Proteomes	UP000000589
Bgee	P09022
CleanEx	MM_HOXA1
ExpressionAtlas	P09022
Genevestigator	P09022
GO	GO:0005634 GO:0043565 GO:0021599 GO:0048646 GO:0009653 GO:0009952 GO:0048844 GO:0071300 GO:0021953 GO:0090103 GO:0050890 GO:0048702 GO:0021612 GO:0021754 GO:0030902 GO:0042472 GO:0008045 GO:0007399 GO:0050905 GO:0007634 GO:0042473 GO:0045944 GO:0050795 GO:0006357 GO:0021569 GO:0021570 GO:0021571 GO:0060876 GO:0007605 GO:0006351
Gene3D	1.10.10.60
InterPro	IPR017970 IPR001356 IPR020479 IPR009057
Pfam	PF00046
PRINTS	PR00024
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS00027 PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
acts_upstream_of_or_within	GO:0090103	cochlea morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090102	cochlea development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071361	cellular response to ethanol	PMID:19091803^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071300	cellular response to retinoic acid	PMID:23723417^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060876	semicircular canal formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060840	artery development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050905	neuromuscular process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050890	cognition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050795	regulation of behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048844	artery morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048839	inner ear development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048702	embryonic neurocranium morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048646	anatomical structure formation involved in morphogenesis	PMID:10529420^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96182	P	results_in_formation_of:(EMAPA:16272)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18787068^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042473	outer ear morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:15367676^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3056069	P	has_participant:(EMAPA:36580)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030902	hindbrain development	PMID:15367676^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3056069	P	results_in_development_of:(EMAPA:16297)\|results_in_development_of:(EMAPA:16301)\|results_in_development_of:(EMAPA:16305)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021953	central nervous system neuron differentiation	PMID:9806922^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857504	P	occurs_in:(EMAPA:16488) results_in_acquisition_of_features_of:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021754	facial nucleus development	PMID:8102800^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857504	P	results_in_development_of:(EMAPA:16660)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021612	facial nerve structural organization	PMID:9806922^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95296	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021599	abducens nerve formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021571	rhombomere 5 development	PMID:10529420^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96182	P	results_in_development_of:(EMAPA:16496)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021571	rhombomere 5 development	PMID:9806922^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857504	P	results_in_development_of:(EMAPA:16305)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021571	rhombomere 5 development	PMID:8102800^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857504	P	results_in_development_of:(EMAPA:16496)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021570	rhombomere 4 development	PMID:10529420^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96182	P	results_in_development_of:(EMAPA:16492)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021570	rhombomere 4 development	PMID:9806922^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857504	P	results_in_development_of:(EMAPA:16301)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021570	rhombomere 4 development	PMID:8102800^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857504	P	results_in_development_of:(EMAPA:16492)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021569	rhombomere 3 development	PMID:9806922^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95296	P	results_in_development_of:(EMAPA:16488)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021569	rhombomere 3 development	PMID:9806922^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857504	P	results_in_development_of:(EMAPA:16297)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:10529420^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96182	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:15367676^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3056069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009653	anatomical structure morphogenesis	PMID:10529420^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96182	P	has_participant:(EMAPA:16399)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009653	anatomical structure morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008045	motor neuron axon guidance	PMID:9806922^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95296	P	occurs_in:(EMAPA:16932) occurs_in:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007634	optokinetic behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007399	nervous system development	PMID:15367676^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3056069	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:15465489^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057 InterPro:IPR020479	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-5617955	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Wang, LL et al. (2009) Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation. Hum. Reprod. 24 562-79 PubMed GONUTS page
↑ Maamar, H et al. (2013) linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in cis. Genes Dev. 27 1260-71 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Rossel, M & Capecchi, MR (1999) Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Development 126 5027-40 PubMed GONUTS page
↑ Wassef, MA et al. (2008) Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors. Development 135 3369-78 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Remacle, S et al. (2004) Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo. Mol. Cell. Biol. 24 8567-75 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Helmbacher, F et al. (1998) Hoxa1 and Krox-20 synergize to control the development of rhombomere 3. Development 125 4739-48 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Dollé, P et al. (1993) Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos. Proc. Natl. Acad. Sci. U.S.A. 90 7666-70 PubMed GONUTS page
↑ Pruitt, SC et al. (2004) Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo. Gene Expr. Patterns 4 671-85 PubMed GONUTS page

[PMID:19091803-1] Wang, LL et al. (2009) Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation. Hum. Reprod. 24 562-79 PubMed GONUTS page

[PMID:23723417-2] Maamar, H et al. (2013) linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in cis. Genes Dev. 27 1260-71 PubMed GONUTS page

[PMID:10529420-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Rossel, M & Capecchi, MR (1999) Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Development 126 5027-40 PubMed GONUTS page

[PMID:18787068-4] Wassef, MA et al. (2008) Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors. Development 135 3369-78 PubMed GONUTS page

[PMID:15367676-5] 5.0 ^5.1 ^5.2 ^5.3 Remacle, S et al. (2004) Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo. Mol. Cell. Biol. 24 8567-75 PubMed GONUTS page

[PMID:9806922-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Helmbacher, F et al. (1998) Hoxa1 and Krox-20 synergize to control the development of rhombomere 3. Development 125 4739-48 PubMed GONUTS page

[PMID:8102800-7] 7.0 ^7.1 ^7.2 Dollé, P et al. (1993) Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos. Proc. Natl. Acad. Sci. U.S.A. 90 7666-70 PubMed GONUTS page

[PMID:15465489-8] Pruitt, SC et al. (2004) Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo. Gene Expr. Patterns 4 671-85 PubMed GONUTS page

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MOUSE:HXA1

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