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PMID:9806922
| Citation |
Helmbacher, F, Pujades, C, Desmarquet, C, Frain, M, Rijli, FM, Chambon, P and Charnay, P (1998) Hoxa1 and Krox-20 synergize to control the development of rhombomere 3. Development 125:4739-48 |
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| Abstract |
The transcription factor genes Hoxa1 and Krox-20 have been shown to play important roles in vertebrate hindbrain segmentation. In this report, we present evidence for novel functions of these genes which co-operate in specifying cellular identity in rhombomere (r) 3. Although Hoxa1 has not been observed to be expressed rostrally to the prospective r3/r4 boundary, its inactivation results in (i) the appearance of patches of cells presenting an r2-like molecular identity within r3, (ii) early neuronal differentiation in r3, normally characteristic of even-numbered rhombomeres, and (iii) abnormal navigation of r3 motor axons, similar to that observed in even-numbered rhombomeres. These phenotypic manifestations become more severe in the context of the additional inactivation of one allele of the Krox-20 gene, demonstrating that Hoxa1 and Krox-20 synergize in a dosage-dependent manner to specify r3 identity and odd- versus even-numbered rhombomere characters. In addition, these data suggest that the control of the development of r3 may not be autonomous but dependent on interactions with Hoxa1-expressing cells. |
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| Keywords |
Animals; Axons/physiology; Crosses, Genetic; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; DNA-Binding Proteins/physiology; Early Growth Response Protein 2; Embryonic and Fetal Development/genetics; Female; Gene Dosage; Genotype; Heterozygote; Homeodomain Proteins/genetics; Homeodomain Proteins/physiology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Motor Neurons/physiology; Neurons/cytology; Neurons/physiology; Polymerase Chain Reaction; Rhombencephalon/cytology; Rhombencephalon/embryology; Transcription Factors/genetics; Transcription Factors/metabolism; Transcription Factors/physiology; Zinc Fingers |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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