GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:HMX3
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Hmx3 (synonyms: Nkx-5.1, Nkx5-1) | |
| Protein Name(s) | Homeobox protein HMX3
Homeobox protein H6 family member 3 Homeobox protein Nkx-5.1 | |
| External Links | ||
| UniProt | P42581 | |
| EMBL | X75330 AJ009935 CH466531 BC139482 BC139483 | |
| CCDS | CCDS21917.1 | |
| PIR | I48690 | |
| RefSeq | NP_032283.3 XP_006507441.1 XP_006507442.1 | |
| UniGene | Mm.323562 | |
| ProteinModelPortal | P42581 | |
| SMR | P42581 | |
| PhosphoSite | P42581 | |
| MaxQB | P42581 | |
| PRIDE | P42581 | |
| Ensembl | ENSMUST00000046093 | |
| GeneID | 15373 | |
| KEGG | mmu:15373 | |
| UCSC | uc009kbo.2 | |
| CTD | 340784 | |
| MGI | MGI:107160 | |
| eggNOG | NOG312519 | |
| GeneTree | ENSGT00760000118779 | |
| HOGENOM | HOG000231923 | |
| HOVERGEN | HBG098273 | |
| InParanoid | P42581 | |
| KO | K09349 | |
| OMA | HPIVTSV | |
| OrthoDB | EOG7B8S4Q | |
| TreeFam | TF320562 | |
| ChiTaRS | Hmx3 | |
| NextBio | 288018 | |
| PRO | PR:P42581 | |
| Proteomes | UP000000589 | |
| Bgee | P42581 | |
| CleanEx | MM_HMX3 | |
| Genevestigator | P42581 | |
| GO | GO:0005634 GO:0043565 GO:0007420 GO:0030154 GO:0007566 GO:0042472 GO:0060135 GO:0050885 GO:0006355 GO:0006351 | |
| Gene3D | 1.10.10.60 | |
| InterPro | IPR017970 IPR001356 IPR020479 IPR009057 | |
| Pfam | PF00046 | |
| PRINTS | PR00024 | |
| SMART | SM00389 | |
| SUPFAM | SSF46689 | |
| PROSITE | PS00027 PS50071 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0043583 |
ear development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060135 |
maternal process involved in female pregnancy |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857577 |
P |
has_participant:(EMAPA:29917) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0050885 |
neuromuscular process controlling balance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857577 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0043583 |
ear development |
ECO:0000315 |
P |
Figure 2. Defects in the inner and middle ear in Six1-deficient mice. |
complete | |||||
|
acts_upstream_of_or_within |
GO:0042472 |
inner ear morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:107159 |
P |
has_participant:(EMAPA:17286) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0042472 |
inner ear morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857577 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007566 |
embryo implantation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857577 |
P |
has_participant:(EMAPA:25765) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0007420 |
brain development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:107159 |
P |
results_in_development_of:(EMAPA:16898) |
Seeded From UniProt |
complete | |
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Ozaki, H et al. (2004) Six1 controls patterning of the mouse otic vesicle. Development 131 551-62 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Amendt, BA et al. (1999) Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site. J. Biol. Chem. 274 11635-42 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Wang, W et al. (1998) Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Development 125 621-34 PubMed GONUTS page
- ↑ 4.0 4.1 Wang, W et al. (2004) Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx. Dev. Cell 7 439-53 PubMed GONUTS page
e
g
m
n
r
