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MOUSE:HINT1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Hint1 (synonyms: Hint, Pkci, Pkci1, Prkcnh1) | |
| Protein Name(s) | Histidine triad nucleotide-binding protein 1
Adenosine 5'-monophosphoramidase Protein kinase C inhibitor 1 Protein kinase C-interacting protein 1 PKCI-1 | |
| External Links | ||
| UniProt | P70349 | |
| EMBL | U60001 AK002965 AK012433 BC070415 BC080296 | |
| CCDS | CCDS24702.1 | |
| PIR | PN0044 | |
| RefSeq | NP_032274.1 | |
| UniGene | Mm.425 | |
| ProteinModelPortal | P70349 | |
| SMR | P70349 | |
| IntAct | P70349 | |
| MINT | MINT-1868587 | |
| BindingDB | P70349 | |
| ChEMBL | CHEMBL1250364 | |
| PhosphoSite | P70349 | |
| REPRODUCTION-2DPAGE | P70349 | |
| MaxQB | P70349 | |
| PaxDb | P70349 | |
| PRIDE | P70349 | |
| Ensembl | ENSMUST00000020504 | |
| GeneID | 15254 | |
| KEGG | mmu:15254 | |
| UCSC | uc007iyj.1 | |
| CTD | 3094 | |
| MGI | MGI:1321133 | |
| eggNOG | COG0537 | |
| GeneTree | ENSGT00510000046448 | |
| HOGENOM | HOG000061064 | |
| HOVERGEN | HBG051906 | |
| InParanoid | P70349 | |
| KO | K02503 | |
| OMA | FRIMNNC | |
| OrthoDB | EOG75QR5T | |
| PhylomeDB | P70349 | |
| TreeFam | TF314862 | |
| NextBio | 287869 | |
| PRO | PR:P70349 | |
| Proteomes | UP000000589 | |
| Bgee | P70349 | |
| CleanEx | MM_HINT1 | |
| ExpressionAtlas | P70349 | |
| Genevestigator | P70349 | |
| GO | GO:0005737 GO:0070062 GO:0000118 GO:0005634 GO:0005886 GO:0016787 GO:0000166 GO:0072332 GO:0009154 GO:0006355 GO:0006351 | |
| Gene3D | 3.30.428.10 | |
| InterPro | IPR019808 IPR001310 IPR011146 | |
| PANTHER | PTHR23089 | |
| Pfam | PF01230 | |
| PRINTS | PR00332 | |
| SUPFAM | SSF54197 | |
| PROSITE | PS00892 PS51084 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0050850 |
positive regulation of calcium-mediated signaling |
ECO:0000315 |
P |
Fig. 2A,B, along with Fig. 1B show that the HINT1 KO fibroblasts demonstrate calcium ion dysregulation, While the immunoblots displayed in Fig. 3A-D, revealed that the decreased ATP-induced Ca2+ entry is likely a consequence of down-regulated expression of Orai1 and STIM1 proteins. |
complete | |||||
|
involved_in |
GO:0050850 |
positive regulation of calcium-mediated signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0072332 |
intrinsic apoptotic signaling pathway by p53 class mediator |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009154 |
purine ribonucleotide catabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000118 |
histone deacetylase complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0072332 |
intrinsic apoptotic signaling pathway by p53 class mediator |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0009154 |
purine ribonucleotide catabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000118 |
histone deacetylase complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0072332 |
intrinsic apoptotic signaling pathway by p53 class mediator |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49773 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49773 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009154 |
purine ribonucleotide catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49773 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49773 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49773 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49773 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49773 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000118 |
histone deacetylase complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49773 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Linde, CI et al. (2013) Histidine triad nucleotide-binding protein 1 (HINT1) regulates Ca(2+) signaling in mouse fibroblasts and neuronal cells via store-operated Ca(2+) entry pathway. Am. J. Physiol., Cell Physiol. 304 C1098-104 PubMed GONUTS page
- ↑ Klein, MG et al. (1998) Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family. Exp. Cell Res. 244 26-32 PubMed GONUTS page
