MOUSE:GRHL2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Grhl2 (synonyms: Bom, Tcfcp2l3)
Protein Name(s)	Grainyhead-like protein 2 homolog Brother of mammalian grainyhead Transcription factor CP2-like 3
External Links
UniProt	Q8K5C0
EMBL	AF411213 BC042575 BC055035
CCDS	CCDS27434.1
RefSeq	NP_080772.2
UniGene	Mm.244612
ProteinModelPortal	Q8K5C0
BioGrid	232985
IntAct	Q8K5C0
MINT	MINT-4117994
STRING	10090.ENSMUSP00000022895
PhosphoSite	Q8K5C0
PaxDb	Q8K5C0
PRIDE	Q8K5C0
Ensembl	ENSMUST00000022895
GeneID	252973
KEGG	mmu:252973
UCSC	uc007vne.2
CTD	79977
MGI	MGI:2182543
eggNOG	NOG241458
GeneTree	ENSGT00760000119235
HOGENOM	HOG000220859
HOVERGEN	HBG054154
InParanoid	Q8K5C0
KO	K09275
OMA	KREQYSA
OrthoDB	EOG7GBFWJ
PhylomeDB	Q8K5C0
TreeFam	TF314132
NextBio	387437
PRO	PR:Q8K5C0
Proteomes	UP000000589
Bgee	Q8K5C0
CleanEx	MM_GRHL2
ExpressionAtlas	Q8K5C0
Genevestigator	Q8K5C0
GO	GO:0005634 GO:0003677 GO:0003700 GO:0007420 GO:0043010 GO:0003208 GO:0048701 GO:0042733 GO:0048568 GO:0060324 GO:0001701 GO:0060463 GO:0035264 GO:0001843 GO:0021915 GO:0010468 GO:0006355 GO:0030323 GO:0006351
InterPro	IPR007604
Pfam	PF04516

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:22955271^[1]	ECO:0000315			P		Fig. 4 shows Down-regulation of Grhl2 affects expression of its target genes.	complete CACAO 5120
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ISB3	F		Seeded From UniProt	complete
involved_in	GO:0045617	negative regulation of keratinocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
involved_in	GO:0044030	regulation of DNA methylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
involved_in	GO:0008544	epidermis development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
involved_in	GO:0001843	neural tube closure	PMID:20978075^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	PMID:20978075^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20978075^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:20978075^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:22955271^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001843	neural tube closure	PMID:20654612^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ISB3	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21081122^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008544	epidermis development	PMID:21081122^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ISB3	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ISB3	C		Seeded From UniProt	complete
involved_in	GO:0070830	bicellular tight junction assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
involved_in	GO:0034329	cell junction assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
involved_in	GO:0003382	epithelial cell morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ISB3	F		Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22955271^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:22955271^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090132	epithelium migration	PMID:22955271^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060487	lung epithelial cell differentiation	PMID:22955271^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:22696678^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003382	epithelial cell morphogenesis	PMID:22696678^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259211 MGI:MGI:2182540 MGI:MGI:2182543 MGI:MGI:2655333 PANTHER:PTN000867451 UniProtKB:Q6ISB3 UniProtKB:Q9NZI5	F		Seeded From UniProt	complete
involved_in	GO:0021915	neural tube development	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2182543 PANTHER:PTN000113123	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2182543 PANTHER:PTN000113123	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000867451 UniProtKB:Q12800	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259211 MGI:MGI:2182540 MGI:MGI:2182543 MGI:MGI:2444691 MGI:MGI:2655333 PANTHER:PTN000112980 UniProtKB:Q12800 UniProtKB:Q6ISB3 UniProtKB:Q8TE85 UniProtKB:Q9NZI5	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0259211 MGI:MGI:2182543 PANTHER:PTN000867451	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035264	multicellular organism growth	PMID:21377456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4942413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034329	cell junction assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ISB3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030323	respiratory tube development	PMID:21377456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4942413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021915	neural tube development	PMID:21377456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4942413	P	results_in_development_of:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:21377456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4942413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008544	epidermis development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:21377456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4942413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:12175488^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12175488^[8]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q8K5C0	P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ISB3	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ISB3	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ISB3	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12175488^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12175488^[8]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q8K5C0	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:25758223^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12175488^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12175488^[8]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q8K5C0	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003382	epithelial cell morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003208	cardiac ventricle morphogenesis	PMID:21377456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4942413	P	has_participant:(EMAPA:17331)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001843	neural tube closure	PMID:21262862^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4331210	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:21262862^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4331210	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ISB3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070830	bicellular tight junction assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060672	epithelial cell morphogenesis involved in placental branching	PMID:25758223^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4340678	P	results_in_morphogenesis_of:(EMAPA:31873)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060463	lung lobe morphogenesis	PMID:21377456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4942413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060324	face development	PMID:21377456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4942413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051973	positive regulation of telomerase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048701	embryonic cranial skeleton morphogenesis	PMID:21377456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4942413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048568	embryonic organ development	PMID:21377456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4942413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045617	negative regulation of keratinocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044030	regulation of DNA methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ISB3	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6ISB3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:21377456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4942413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:21377456^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4942413	P		Seeded From UniProt	complete
involved_in	GO:0070830	bicellular tight junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ISB3 ensembl:ENSP00000251808	P		Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ISB3 ensembl:ENSP00000251808	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ISB3 ensembl:ENSP00000251808	P		Seeded From UniProt	complete
involved_in	GO:0045617	negative regulation of keratinocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ISB3 ensembl:ENSP00000251808	P		Seeded From UniProt	complete
involved_in	GO:0044030	regulation of DNA methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ISB3 ensembl:ENSP00000251808	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ISB3 ensembl:ENSP00000251808	F		Seeded From UniProt	complete
involved_in	GO:0034329	cell junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ISB3 ensembl:ENSP00000251808	P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ISB3 ensembl:ENSP00000251808	F		Seeded From UniProt	complete
involved_in	GO:0008544	epidermis development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ISB3 ensembl:ENSP00000251808	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ISB3 ensembl:ENSP00000251808	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ISB3 ensembl:ENSP00000251808	P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ISB3 ensembl:ENSP00000251808	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ISB3 ensembl:ENSP00000251808	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ISB3 ensembl:ENSP00000251808	C		Seeded From UniProt	complete
involved_in	GO:0003382	epithelial cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ISB3 ensembl:ENSP00000251808	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ISB3 ensembl:ENSP00000251808	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040167	F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040167	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Varma, S et al. (2012) The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation. J. Biol. Chem. 287 37282-95 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Werth, M et al. (2010) The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex. Development 137 3835-45 PubMed GONUTS page
↑ Rifat, Y et al. (2010) Regional neural tube closure defined by the Grainy head-like transcription factors. Dev. Biol. 345 237-45 PubMed GONUTS page
↑ ^4.0 ^4.1 Boglev, Y et al. (2011) The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity. Dev. Biol. 349 512-22 PubMed GONUTS page
↑ ^5.0 ^5.1 Senga, K et al. (2012) Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25. Mol. Biol. Cell 23 2845-55 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 Pyrgaki, C et al. (2011) Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Dev. Biol. 353 38-49 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Wilanowski, T et al. (2002) A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech. Dev. 114 37-50 PubMed GONUTS page
↑ ^9.0 ^9.1 Walentin, K et al. (2015) A Grhl2-dependent gene network controls trophoblast branching morphogenesis. Development 142 1125-36 PubMed GONUTS page
↑ ^10.0 ^10.1 Brouns, MR et al. (2011) Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse. Hum. Mol. Genet. 20 1536-46 PubMed GONUTS page

[PMID:22955271-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Varma, S et al. (2012) The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation. J. Biol. Chem. 287 37282-95 PubMed GONUTS page

[PMID:20978075-2] 2.0 ^2.1 ^2.2 ^2.3 Werth, M et al. (2010) The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex. Development 137 3835-45 PubMed GONUTS page

[PMID:20654612-3] Rifat, Y et al. (2010) Regional neural tube closure defined by the Grainy head-like transcription factors. Dev. Biol. 345 237-45 PubMed GONUTS page

[PMID:21081122-4] 4.0 ^4.1 Boglev, Y et al. (2011) The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity. Dev. Biol. 349 512-22 PubMed GONUTS page

[PMID:22696678-5] 5.0 ^5.1 Senga, K et al. (2012) Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25. Mol. Biol. Cell 23 2845-55 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21377456-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 Pyrgaki, C et al. (2011) Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Dev. Biol. 353 38-49 PubMed GONUTS page

[PMID:12175488-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Wilanowski, T et al. (2002) A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech. Dev. 114 37-50 PubMed GONUTS page

[PMID:25758223-9] 9.0 ^9.1 Walentin, K et al. (2015) A Grhl2-dependent gene network controls trophoblast branching morphogenesis. Development 142 1125-36 PubMed GONUTS page

[PMID:21262862-10] 10.0 ^10.1 Brouns, MR et al. (2011) Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse. Hum. Mol. Genet. 20 1536-46 PubMed GONUTS page

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MOUSE:GRHL2

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