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PMID:12175488

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Citation

Wilanowski, T, Tuckfield, A, Cerruti, L, O'Connell, S, Saint, R, Parekh, V, Tao, J, Cunningham, JM and Jane, SM (2002) A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech. Dev. 114:37-50

Abstract

The Drosophila transcription factor Grainyhead regulates several key developmental processes. Three mammalian genes, CP2, LBP-1a and LBP-9 have been previously identified as homologues of grainyhead. We now report the cloning of two new mammalian genes (Mammalian grainyhead (MGR) and Brother-of-MGR (BOM)) and one new Drosophila gene (dCP2) that rewrite the phylogeny of this family. We demonstrate that MGR and BOM are more closely related to grh, whereas CP2, LBP-1a and LBP-9 are descendants of the dCP2 gene. MGR shares the greatest sequence homology with grh, is expressed in tissue-restricted patterns more comparable to grh and binds to and transactivates the promoter of the human Engrailed-1 gene, the mammalian homologue of the key grainyhead target gene, engrailed. This sequence and functional conservation indicates that the new mammalian members of this family play important developmental roles.

Links

PubMed

Keywords

Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cloning, Molecular; DNA/metabolism; DNA-Binding Proteins/metabolism; Dimerization; Drosophila; Drosophila Proteins; Embryo, Mammalian/pathology; Embryo, Nonmammalian; Evolution, Molecular; Exons; Homeodomain Proteins/metabolism; Humans; In Situ Hybridization; Mice; Molecular Sequence Data; Nuclear Proteins; Phylogeny; Polymerase Chain Reaction; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Repressor Proteins; Sequence Homology, Amino Acid; Tissue Distribution; Transcription Factors/biosynthesis; Transcription Factors/metabolism; Transcription, Genetic; Transcriptional Activation

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


See also

References

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