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PMID:12175488
| Citation |
Wilanowski, T, Tuckfield, A, Cerruti, L, O'Connell, S, Saint, R, Parekh, V, Tao, J, Cunningham, JM and Jane, SM (2002) A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech. Dev. 114:37-50 |
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| Abstract |
The Drosophila transcription factor Grainyhead regulates several key developmental processes. Three mammalian genes, CP2, LBP-1a and LBP-9 have been previously identified as homologues of grainyhead. We now report the cloning of two new mammalian genes (Mammalian grainyhead (MGR) and Brother-of-MGR (BOM)) and one new Drosophila gene (dCP2) that rewrite the phylogeny of this family. We demonstrate that MGR and BOM are more closely related to grh, whereas CP2, LBP-1a and LBP-9 are descendants of the dCP2 gene. MGR shares the greatest sequence homology with grh, is expressed in tissue-restricted patterns more comparable to grh and binds to and transactivates the promoter of the human Engrailed-1 gene, the mammalian homologue of the key grainyhead target gene, engrailed. This sequence and functional conservation indicates that the new mammalian members of this family play important developmental roles. |
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| Keywords |
Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cloning, Molecular; DNA/metabolism; DNA-Binding Proteins/metabolism; Dimerization; Drosophila; Drosophila Proteins; Embryo, Mammalian/pathology; Embryo, Nonmammalian; Evolution, Molecular; Exons; Homeodomain Proteins/metabolism; Humans; In Situ Hybridization; Mice; Molecular Sequence Data; Nuclear Proteins; Phylogeny; Polymerase Chain Reaction; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Repressor Proteins; Sequence Homology, Amino Acid; Tissue Distribution; Transcription Factors/biosynthesis; Transcription Factors/metabolism; Transcription, Genetic; Transcriptional Activation |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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