MOUSE:GOPC

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Gopc
Protein Name(s)	Golgi-associated PDZ and coiled-coil motif-containing protein PDZ protein interacting specifically with TC10 PIST
External Links
UniProt	Q8BH60
EMBL	AF287893 AB052838 AK030427 AK030637 AK032613 BC051171
CCDS	CCDS35898.1
RefSeq	NP_001186201.1 NP_444417.2
UniGene	Mm.390258
ProteinModelPortal	Q8BH60
SMR	Q8BH60
BioGrid	220478
IntAct	Q8BH60
MINT	MINT-1489410
STRING	10090.ENSMUSP00000020008
PhosphoSite	Q8BH60
MaxQB	Q8BH60
PaxDb	Q8BH60
PRIDE	Q8BH60
Ensembl	ENSMUST00000020008
GeneID	94221
KEGG	mmu:94221
UCSC	uc007fbf.2 uc007fbg.2
CTD	57120
MGI	MGI:2149946
eggNOG	NOG278699
GeneTree	ENSGT00550000074582
HOGENOM	HOG000280727
HOVERGEN	HBG057507
InParanoid	Q8BH60
PhylomeDB	Q8BH60
Reactome	R-MMU-5627083
ChiTaRS	Gopc
NextBio	352211
PRO	PR:Q8BH60
Proteomes	UP000000589
Bgee	Q8BH60
ExpressionAtlas	Q8BH60
Genevisible	Q8BH60
GO	GO:0030054 GO:0005737 GO:0030425 GO:0005794 GO:0000139 GO:0016020 GO:0005886 GO:0014069 GO:0045211 GO:0043234 GO:0045202 GO:0030140 GO:0005109 GO:0030695 GO:0044325 GO:0008022 GO:0042803 GO:0019905 GO:0006914 GO:0051260 GO:0015031 GO:0050790 GO:0007289
Gene3D	2.30.42.10
InterPro	IPR001478
Pfam	PF00595
SMART	SM00228
SUPFAM	SSF50156
PROSITE	PS50106

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0042803	protein homodimerization activity	PMID:11520064^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8BH60	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:11520064^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9EQD0	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:11520064^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q61091	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11520064^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:11520064^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:11520064^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9EQD0	F		Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:11520064^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q61091	F		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HD26	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HD26	F		Seeded From UniProt	complete
part_of	GO:0030140	trans-Golgi network transport vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HD26	C		Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HD26	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HD26	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HD26	C		Seeded From UniProt	complete
	GO:0097223	sperm part	PMID:26179146^[2]	ECO:0000314			C		Figure 7a	complete CACAO 11059
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HD26	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000009	negative regulation of protein localization to cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HD26	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HD26	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:12372286^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HD26	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043004	cytoplasmic sequestering of CFTR protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HD26	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:18468998^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HD26	C		Seeded From UniProt	complete
enables	GO:0030695	GTPase regulator activity	PMID:11162552^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030140	trans-Golgi network transport vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HD26	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HD26	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010360	negative regulation of anion channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HD26	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007289	spermatid nucleus differentiation	PMID:16765935^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386794	P	occurs_in:(CL:0000018)	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HD26	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HD26	C		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030695	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR038879	C		Seeded From UniProt	complete
involved_in	GO:0043004	cytoplasmic sequestering of CFTR protein	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR038879	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:12885772^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Yao, R et al. (2001) Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. Biochem. Biophys. Res. Commun. 286 771-8 PubMed GONUTS page
↑ Li, Y et al. (2015) FAM170B, a novel acrosomal protein involved in fertilization in mice. Mol. Reprod. Dev. 82 787-96 PubMed GONUTS page
↑ Yue, Z et al. (2002) A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. Neuron 35 921-33 PubMed GONUTS page
↑ Lyssand, JS et al. (2008) Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. J. Biol. Chem. 283 18792-800 PubMed GONUTS page
↑ Neudauer, CL et al. (2001) PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10. Biochem. Biophys. Res. Commun. 280 541-7 PubMed GONUTS page
↑ Catena, R et al. (2006) Changes in intranuclear chromatin architecture induce bipolar nuclear localization of histone variant H1T2 in male haploid spermatids. Dev. Biol. 296 231-238 PubMed GONUTS page
↑ Hassel, B et al. (2003) CALEB/NGC interacts with the Golgi-associated protein PIST. J. Biol. Chem. 278 40136-43 PubMed GONUTS page

[PMID:11520064-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Yao, R et al. (2001) Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. Biochem. Biophys. Res. Commun. 286 771-8 PubMed GONUTS page

[PMID:26179146-2] Li, Y et al. (2015) FAM170B, a novel acrosomal protein involved in fertilization in mice. Mol. Reprod. Dev. 82 787-96 PubMed GONUTS page

[PMID:12372286-3] Yue, Z et al. (2002) A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. Neuron 35 921-33 PubMed GONUTS page

[PMID:18468998-4] Lyssand, JS et al. (2008) Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. J. Biol. Chem. 283 18792-800 PubMed GONUTS page

[PMID:11162552-5] Neudauer, CL et al. (2001) PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10. Biochem. Biophys. Res. Commun. 280 541-7 PubMed GONUTS page

[PMID:16765935-6] Catena, R et al. (2006) Changes in intranuclear chromatin architecture induce bipolar nuclear localization of histone variant H1T2 in male haploid spermatids. Dev. Biol. 296 231-238 PubMed GONUTS page

[PMID:12885772-7] Hassel, B et al. (2003) CALEB/NGC interacts with the Golgi-associated protein PIST. J. Biol. Chem. 278 40136-43 PubMed GONUTS page

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MOUSE:GOPC

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