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MOUSE:GBRD

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Gabrd
Protein Name(s) Gamma-aminobutyric acid receptor subunit delta

GABA(A) receptor subunit delta

External Links
UniProt P22933
EMBL AH001900
S42882
CCDS CCDS19028.1
PIR A36303
I52630
RefSeq NP_032098.2
UniGene Mm.388925
ProteinModelPortal P22933
SMR P22933
STRING 10090.ENSMUSP00000030925
ChEMBL CHEMBL2094133
iPTMnet P22933
PhosphoSite P22933
PaxDb P22933
PRIDE P22933
Ensembl ENSMUST00000030925
GeneID 14403
KEGG mmu:14403
UCSC uc008wdf.2
CTD 2563
MGI MGI:95622
eggNOG KOG3643
ENOG410XPWH
HOGENOM HOG000231335
HOVERGEN HBG051707
InParanoid P22933
KO K05184
OMA RARFKPI
OrthoDB EOG712TVZ
PhylomeDB P22933
TreeFam TF315453
PRO PR:P22933
Proteomes UP000000589
Bgee P22933
ExpressionAtlas P22933
Genevisible P22933
GO GO:0030054
GO:0034707
GO:0045211
GO:0005254
GO:0005230
GO:0004890
GO:0007268
Gene3D 2.70.170.10
InterPro IPR006028
IPR008098
IPR006202
IPR006201
IPR006029
IPR018000
PANTHER PTHR18945
Pfam PF02931
PF02932
PRINTS PR01722
PR00253
PR00252
SUPFAM SSF63712
SSF90112
TIGRFAMs TIGR00860
PROSITE PS00236

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0051932

synaptic transmission, GABAergic

PMID:25339733[1]

ECO:0000314

P

Figure 2 & 7, up-regulation of protein conferring sensitivity of synaptic activity

complete
CACAO 12241

GO:0030424

axon

PMID:25339733[1]

ECO:0000314

C

Staining with the antibody showed broad distribution of δ subunit on the soma, axon, and dendritic regions of acutely dissociated CA1PCs and DGGCs acquired from NSW and control mice (Fig. 3A). Mouse GBRD.

complete
CACAO 12242

GO:0030424

axon

PMID:25339733[1]

ECO:0000314

C

Staining the antibody showed broad distribution of delta subunits (δ subunit) on the axon. Immunohistochemical distribution of delta subunit in hippocampal CA1 neurons top portion of figure 3 (referred to as 3A in text). From UniProt: GABA(A) (uniprotID: P22933). Mus musculus

complete
CACAO 12394

GO:0030425

dendrite

PMID:25339733[1]

ECO:0000314

C

Staining the antibody showed broad distribution of delta subunits (δ subunit) on dendritic regions. Immunohistochemical distribution of delta subunit in hippocampal CA1 neurons top portion of figure 3 (referred to as figure 3A within paper). From UniProt: GABA(A) (uniprotID: P22933). Mus musculus

complete
CACAO 12395

GO:0043025

neuronal cell body

PMID:25339733[1]

ECO:0000314

C

Staining the antibody showed broad distribution of delta subunits (δ subunit) on the soma. Immunohistochemical distribution of delta subunit in hippocampal CA1 neurons top portion of figure 3 (referred to as figure 3A within paper). From UniProt: GABA(A) (uniprotID: P22933). Mus musculus

complete
CACAO 12396

enables

GO:1904315

transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

PMID:14627650[2]

ECO:0006013

patch-clamp recording evidence used in manual assertion

F

  • occurs_in:(GO:0098982)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

enables

GO:1904315

transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

PMID:14627650[2]

ECO:0001225

knockout evidence used in manual assertion

F

  • occurs_in:(GO:0098982)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0099055

integral component of postsynaptic membrane

PMID:14627650[2]

ECO:0006003

electron microscopy evidence used in manual assertion

C

  • part_of:(GO:0098982)
  • part_of:(UBERON:0000061)
  • part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0098982

GABA-ergic synapse

PMID:14627650[2]

ECO:0006013

patch-clamp recording evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0098982

GABA-ergic synapse

PMID:14627650[2]

ECO:0006003

electron microscopy evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0098982

GABA-ergic synapse

PMID:14627650[2]

ECO:0001225

knockout evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:1902711

GABA-A receptor complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95621
PANTHER:PTN000435002
RGD:2649
RGD:2650
UniProtKB:P18505
UniProtKB:P28472

C

Seeded From UniProt

complete

involved_in

GO:0050877

nervous system process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87888
PANTHER:PTN000434994
UniProtKB:P11230
UniProtKB:P17787
UniProtKB:P43681

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95747
PANTHER:PTN000434994
UniProtKB:G5EDF1
UniProtKB:P11230
WB:WBGene00006765
WB:WBGene00006774

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95747
PANTHER:PTN000434994
RGD:2351
RGD:621544
WB:WBGene00000042
WB:WBGene00002974
WB:WBGene00006765
WB:WBGene00006774

C

Seeded From UniProt

complete

involved_in

GO:0042391

regulation of membrane potential

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87885
MGI:MGI:87887
MGI:MGI:87888
MGI:MGI:87890
MGI:MGI:87891
MGI:MGI:87892
MGI:MGI:87893
MGI:MGI:87894
MGI:MGI:87895
MGI:MGI:95747
MGI:MGI:95751
MGI:MGI:99779
PANTHER:PTN000434994
RGD:2348
UniProtKB:P02708
UniProtKB:P23415

P

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95613
PANTHER:PTN000434994
UniProtKB:P23416
UniProtKB:P36544
UniProtKB:Q401N2
WB:WBGene00000055
WB:WBGene00002974
WB:WBGene00006797

P

Seeded From UniProt

complete

involved_in

GO:0007268

chemical synaptic transmission

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003011
FB:FBgn0086778
MGI:MGI:103156
MGI:MGI:95613
MGI:MGI:95623
MGI:MGI:95747
PANTHER:PTN000434994
RGD:2648
RGD:61859
RGD:61901
UniProtKB:P48167
WB:WBGene00000050
WB:WBGene00000054

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000434994
UniProtKB:P11230
UniProtKB:P17787
UniProtKB:P30926
UniProtKB:P32297
UniProtKB:P36544
UniProtKB:P43681
UniProtKB:Q15822

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1861899
MGI:MGI:95623
MGI:MGI:95750
PANTHER:PTN000434994
RGD:2649
RGD:2650
RGD:61855
RGD:61861
RGD:621229
UniProtKB:O75311
UniProtKB:P23415
UniProtKB:P23416
UniProtKB:P28472
UniProtKB:P48167
UniProtKB:Q9UGM1
WB:WBGene00000955
WB:WBGene00001133
WB:WBGene00001591
WB:WBGene00001592

C

Seeded From UniProt

complete

contributes_to

GO:0005230

extracellular ligand-gated ion channel activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000434994
WB:WBGene00000043
WB:WBGene00001512
WB:WBGene00003386
WB:WBGene00006774
WB:WBGene00012857
WB:WBGene00017375

F

Seeded From UniProt

complete

contributes_to

GO:0004890

GABA-A receptor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95621
MGI:MGI:95626
PANTHER:PTN000435002
RGD:2649
RGD:2650
RGD:2651
RGD:61901
RGD:61902
RGD:620532
UniProtKB:P28472
WB:WBGene00001512

F

Seeded From UniProt

complete

part_of

GO:0099055

integral component of postsynaptic membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:61901

C

Seeded From UniProt

complete

part_of

GO:0098982

GABA-ergic synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:61901

C

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:61901

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007268

chemical synaptic transmission

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:61901

P

Seeded From UniProt

complete

enables

GO:0004890

GABA-A receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:61901

F

Seeded From UniProt

complete

involved_in

GO:0060078

regulation of postsynaptic membrane potential

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:1904315

P

Seeded From UniProt

complete

involved_in

GO:0060078

regulation of postsynaptic membrane potential

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:1904315

P

Seeded From UniProt

complete

involved_in

GO:1902476

chloride transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005254

P

Seeded From UniProt

complete

part_of

GO:0099055

integral component of postsynaptic membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18506
ensembl:ENSRNOP00000022246

C

Seeded From UniProt

complete

part_of

GO:0098982

GABA-ergic synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18506
ensembl:ENSRNOP00000022246

C

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18506
ensembl:ENSRNOP00000022246

C

Seeded From UniProt

complete

involved_in

GO:0007268

chemical synaptic transmission

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18506
ensembl:ENSRNOP00000022246

P

Seeded From UniProt

complete

enables

GO:0004890

GABA-A receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P18506
ensembl:ENSRNOP00000022246

F

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006028
InterPro:IPR006201

F

Seeded From UniProt

complete

enables

GO:0004890

GABA-A receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008098

F

Seeded From UniProt

complete

enables

GO:0005216

ion channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006028
InterPro:IPR006201

F

Seeded From UniProt

complete

enables

GO:0005230

extracellular ligand-gated ion channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006202
InterPro:IPR036734

F

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006029
InterPro:IPR006202
InterPro:IPR008098
InterPro:IPR036719
InterPro:IPR036734

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008098

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006028
InterPro:IPR006029
InterPro:IPR006201
InterPro:IPR006202
InterPro:IPR036719
InterPro:IPR036734

C

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006028
InterPro:IPR006201

P

Seeded From UniProt

complete

part_of

GO:0034707

chloride channel complex

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0869

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0006821

chloride transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0869

P

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

part_of

GO:0045211

postsynaptic membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0628
UniProtKB-SubCell:SL-0219

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0005254

chloride channel activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0869

F

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0770

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Carver, CM et al. (2014) Perimenstrual-like hormonal regulation of extrasynaptic δ-containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity. J. Neurosci. 34 14181-97 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Wei, W et al. (2003) Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus. J. Neurosci. 23 10650-61 PubMed GONUTS page
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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