GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:GASR
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Cckbr | |
| Protein Name(s) | Gastrin/cholecystokinin type B receptor
CCK-B receptor CCK-BR Cholecystokinin-2 receptor CCK2-R | |
| External Links | ||
| UniProt | P56481 | |
| EMBL | AF019371 AF264178 AF264177 AK028325 | |
| CCDS | CCDS21651.1 | |
| RefSeq | NP_031653.1 | |
| UniGene | Mm.44513 | |
| ProteinModelPortal | P56481 | |
| SMR | P56481 | |
| MINT | MINT-1534414 | |
| BindingDB | P56481 | |
| ChEMBL | CHEMBL2111334 | |
| GuidetoPHARMACOLOGY | 77 | |
| PhosphoSite | P56481 | |
| PaxDb | P56481 | |
| PRIDE | P56481 | |
| Ensembl | ENSMUST00000033189 | |
| GeneID | 12426 | |
| KEGG | mmu:12426 | |
| UCSC | uc009iyd.1 | |
| CTD | 887 | |
| MGI | MGI:99479 | |
| eggNOG | NOG238659 | |
| HOGENOM | HOG000294067 | |
| HOVERGEN | HBG036927 | |
| InParanoid | P56481 | |
| KO | K04195 | |
| OMA | WRAFDGP | |
| PhylomeDB | P56481 | |
| TreeFam | TF315303 | |
| Reactome | REACT_188573 REACT_207651 REACT_235286 | |
| NextBio | 281236 | |
| PRO | PR:P56481 | |
| Proteomes | UP000000589 | |
| Bgee | P56481 | |
| CleanEx | MM_CCKBR | |
| ExpressionAtlas | P56481 | |
| Genevestigator | P56481 | |
| GO | GO:0016021 GO:0016020 GO:0005886 GO:0015054 GO:0031741 GO:0048565 GO:0001696 GO:0048732 GO:0008284 GO:0007204 | |
| InterPro | IPR009126 IPR000314 IPR000276 IPR017452 | |
| Pfam | PF00001 | |
| PRINTS | PR01822 PR00527 PR00237 | |
| PROSITE | PS00237 PS50262 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0015054 |
gastrin receptor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:2000987 |
positive regulation of behavioral fear response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2290 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0090274 |
positive regulation of somatostatin secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2290 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0070371 |
ERK1 and ERK2 cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2290 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051968 |
positive regulation of synaptic transmission, glutamatergic |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2290 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051930 |
regulation of sensory perception of pain |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2290 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0050806 |
positive regulation of synaptic transmission |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2290 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048732 |
gland development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2384535 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048565 |
digestive tract development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2384535 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045851 |
pH reduction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2180591 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0044849 |
estrous cycle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2290 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0038188 |
cholecystokinin signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032230 |
positive regulation of synaptic transmission, GABAergic |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2290 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031741 |
type B gastrin/cholecystokinin receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017046 |
peptide hormone binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:16894)|part_of:(EMAPA:17503) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0015054 |
gastrin receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0015054 |
gastrin receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2290 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2290 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007200 |
phospholipase C-activating G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006915 |
apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2290 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2290 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2290 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2290 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004951 |
cholecystokinin receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0002209 |
behavioral defense response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2290 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001821 |
histamine secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2290 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001696 |
gastric acid secretion |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:108482 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001696 |
gastric acid secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2384535 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0038188 |
cholecystokinin signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P32239 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0031741 |
type B gastrin/cholecystokinin receptor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P32239 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017046 |
peptide hormone binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P32239 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0015054 |
gastrin receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P32239 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P32239 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P32239 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007200 |
phospholipase C-activating G protein-coupled receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P32239 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004951 |
cholecystokinin receptor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P32239 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0015054 |
gastrin receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000276 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004930 |
G protein-coupled receptor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Fukushima, Y et al. (2004) Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa. Eur. J. Pharmacol. 502 243-52 PubMed GONUTS page
- ↑ Schinke, T et al. (2009) Impaired gastric acidification negatively affects calcium homeostasis and bone mass. Nat. Med. 15 674-81 PubMed GONUTS page
- ↑ Nagata, A et al. (1996) G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo. Proc. Natl. Acad. Sci. U.S.A. 93 11825-30 PubMed GONUTS page
c
e
g
p
- GO:0017046 ! peptide hormone binding
- GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway
- GO:0045851 ! pH reduction
- GO:0005886 ! plasma membrane
- GO:0032230 ! positive regulation of synaptic transmission, GABAergic
- GO:0050806 ! positive regulation of synaptic transmission
- GO:0007204 ! positive regulation of cytosolic calcium ion concentration
- GO:2000987 ! positive regulation of behavioral fear response
- GO:0090274 ! positive regulation of somatostatin secretion
- GO:0051968 ! positive regulation of synaptic transmission, glutamatergic
- GO:0008284 ! positive regulation of cell population proliferation
