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MOUSE:GAB2
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Gab2 | |
| Protein Name(s) | GRB2-associated-binding protein 2
GRB2-associated binder 2 Growth factor receptor bound protein 2-associated protein 2 PH domain-containing adaptor molecule p97 | |
| External Links | ||
| UniProt | Q9Z1S8 | |
| EMBL | AF104244 AB018414 | |
| UniGene | Mm.42033 | |
| ProteinModelPortal | Q9Z1S8 | |
| SMR | Q9Z1S8 | |
| DIP | DIP-41351N | |
| IntAct | Q9Z1S8 | |
| MINT | MINT-244287 | |
| PhosphoSite | Q9Z1S8 | |
| MaxQB | Q9Z1S8 | |
| PRIDE | Q9Z1S8 | |
| MGI | MGI:1333854 | |
| eggNOG | NOG83177 | |
| HOVERGEN | HBG051685 | |
| InParanoid | Q9Z1S8 | |
| PhylomeDB | Q9Z1S8 | |
| Reactome | REACT_213364 | |
| PRO | PR:Q9Z1S8 | |
| Proteomes | UP000000589 | |
| Genevestigator | Q9Z1S8 | |
| GO | GO:0005737 GO:0005829 GO:0005886 GO:0005547 GO:0043325 GO:0005068 GO:0016477 GO:0007229 GO:0030316 GO:0048015 GO:0008284 GO:0043306 GO:0007169 | |
| Gene3D | 2.30.29.30 | |
| InterPro | IPR001849 IPR011993 | |
| Pfam | PF00169 | |
| SMART | SM00233 | |
| PROSITE | PS50003 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008360 |
regulation of cell shape |
ECO:0000315 |
P |
Figure 7A illustrates a more elongated cellular morphology in Gab2 mutants. Figure 7C provides further evidence by showing Gab2 mutants were 2 to 7 times more likely to have an elongated cell shape. |
complete | |||||
| GO:0010634 |
positive regulation of epithelial cell migration |
ECO:0000315 |
P |
Figure 8 |
complete | |||||
|
involved_in |
GO:0010634 |
positive regulation of epithelial cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048015 |
phosphatidylinositol-mediated signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043325 |
phosphatidylinositol-3,4-bisphosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043306 |
positive regulation of mast cell degranulation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030316 |
osteoclast differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005547 |
phosphatidylinositol-3,4,5-trisphosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005068 |
transmembrane receptor protein tyrosine kinase adaptor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0035556 |
intracellular signal transduction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621367 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621367 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0030316 |
osteoclast differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621367 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019903 |
protein phosphatase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:621367 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0016477 |
cell migration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007229 |
integrin-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005068 |
transmembrane receptor protein tyrosine kinase adaptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005068 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005068 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-MMU-9007137 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Zhang, X et al. (2013) Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility. Mol. Cell. Biol. 33 1657-70 PubMed GONUTS page
- ↑ 2.0 2.1 Gu, H et al. (2001) Essential role for Gab2 in the allergic response. Nature 412 186-90 PubMed GONUTS page
- ↑ 3.0 3.1 Yu, M et al. (2006) Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI. J. Immunol. 176 2421-9 PubMed GONUTS page
- ↑ Wada, T et al. (2005) The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat. Med. 11 394-9 PubMed GONUTS page
- ↑ 5.0 5.1 Yu, WM et al. (2002) Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration. Blood 99 2351-9 PubMed GONUTS page
c
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p
- GO:0005547 ! phosphatidylinositol-3,4,5-trisphosphate binding
- GO:0043325 ! phosphatidylinositol-3,4-bisphosphate binding
- GO:0048015 ! phosphatidylinositol-mediated signaling
- GO:0005886 ! plasma membrane
- GO:0010634 ! positive regulation of epithelial cell migration
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0043306 ! positive regulation of mast cell degranulation
- GO:0032991 ! protein-containing complex
- GO:0019904 ! protein domain specific binding
- GO:0019903 ! protein phosphatase binding
