GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:FABP5
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Fabp5 (synonyms: Fabpe, Klbp, Mal1) | |
| Protein Name(s) | Fatty acid-binding protein, epidermal
Epidermal-type fatty acid-binding protein E-FABP Fatty acid-binding protein 5 Keratinocyte lipid-binding protein Psoriasis-associated fatty acid-binding protein homolog PA-FABP | |
| External Links | ||
| UniProt | Q05816 | |
| EMBL | X70100 AJ223066 AF061015 AF061014 AK008782 AK011551 BC002008 | |
| CCDS | CCDS38388.1 | |
| PIR | A47497 | |
| RefSeq | NP_034764.1 | |
| UniGene | Mm.741 | |
| PDB | 4AZN 4AZO 4AZP 4AZQ | |
| PDBsum | 4AZN 4AZO 4AZP 4AZQ | |
| ProteinModelPortal | Q05816 | |
| SMR | Q05816 | |
| BioGrid | 200959 | |
| IntAct | Q05816 | |
| MINT | MINT-1869678 | |
| STRING | 10090.ENSMUSP00000029046 | |
| iPTMnet | Q05816 | |
| PhosphoSitePlus | Q05816 | |
| REPRODUCTION-2DPAGE | Q05816 | |
| UCD-2DPAGE | Q05816 | |
| EPD | Q05816 | |
| PaxDb | Q05816 | |
| PeptideAtlas | Q05816 | |
| PRIDE | Q05816 | |
| Ensembl | ENSMUST00000029046 | |
| GeneID | 16592 | |
| KEGG | mmu:16592 | |
| UCSC | uc008opg.2 | |
| CTD | 2171 | |
| MGI | MGI:101790 | |
| eggNOG | KOG4015 ENOG4111US8 | |
| GeneTree | ENSGT00760000118898 | |
| HOGENOM | HOG000004829 | |
| HOVERGEN | HBG005633 | |
| InParanoid | Q05816 | |
| KO | K08754 | |
| OMA | VECDMNG | |
| OrthoDB | EOG091G0QSV | |
| PhylomeDB | Q05816 | |
| TreeFam | TF316894 | |
| Reactome | [www.reactome.org/content/detail/R-MMU-163560 R-MMU-163560] [www.reactome.org/content/detail/R-MMU-5362517 R-MMU-5362517] [www.reactome.org/content/detail/R-MMU-6798695 R-MMU-6798695] | |
| PRO | PR:Q05816 | |
| Proteomes | UP000000589 | |
| Bgee | ENSMUSG00000027533 | |
| CleanEx | MM_FABP5 | |
| ExpressionAtlas | Q05816 | |
| Genevisible | Q05816 | |
| GO | GO:0005737 GO:0070062 GO:0005504 GO:0005215 GO:0006006 GO:0015758 GO:0006629 GO:0006656 GO:0009611 | |
| Gene3D | 2.40.128.20 | |
| InterPro | IPR012674 IPR011038 IPR000463 IPR031259 IPR000566 | |
| PANTHER | PTHR11955 | |
| Pfam | PF00061 | |
| PRINTS | PR00178 | |
| SUPFAM | SSF50814 | |
| PROSITE | PS00214 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0048144 |
fibroblast proliferation |
ECO:0000315 |
P |
MOUSE FABP5 // 3T3 clones that overexpress different levels of FABP5 were produced (Fig. 2F) and their rates of proliferation were measured using MTT assay. Overexpression of FABP5 facilitated the proliferation of 3T3 cells and did so in a dose-responsive fashion (Fig. 2G). |
complete | |||||
|
involved_in |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035360 |
positive regulation of peroxisome proliferator activated receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001972 |
retinoic acid binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0099178 |
regulation of retrograde trans-synaptic signaling by endocanabinoid |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051930 |
regulation of sensory perception of pain |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031392 |
regulation of prostaglandin biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042593 |
glucose homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2450172 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010829 |
negative regulation of glucose transmembrane transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2450172 |
P |
occurs_in:(CL:0000136) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0006656 |
phosphatidylcholine biosynthetic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:95476 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006629 |
lipid metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2450172 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006006 |
glucose metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2450172 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005504 |
fatty acid binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005504 |
fatty acid binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:70997 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q01469 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q01469 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q01469 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005504 |
fatty acid binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q01469 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045202 |
synapse |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045211 |
postsynaptic membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Levi, L et al. (2013) Genetic ablation of the fatty acid-binding protein FABP5 suppresses HER2-induced mammary tumorigenesis. Cancer Res. 73 4770-80 PubMed GONUTS page
- ↑ Syamsunarno, MR et al. (2014) Fatty acid binding protein 4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress. PLoS ONE 9 e90825 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Haj-Dahmane, S et al. (2018) Fatty-acid-binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses. Proc. Natl. Acad. Sci. U.S.A. 115 3482-3487 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Schug, TT et al. (2007) Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors. Cell 129 723-33 PubMed GONUTS page
- ↑ 5.0 5.1 Bogdan, D et al. (2018) Fatty acid-binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation. J. Biol. Chem. 293 5295-5306 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Maeda, K et al. (2003) Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes 52 300-7 PubMed GONUTS page
- ↑ Guthmann, F et al. (2004) Phenotype of palmitic acid transport and of signalling in alveolar type II cells from E/H-FABP double-knockout mice: contribution of caveolin-1 and PPARgamma. Biochim. Biophys. Acta 1636 196-204 PubMed GONUTS page
e
p
- GO:0006656 ! phosphatidylcholine biosynthetic process
- GO:0005886 ! plasma membrane
- GO:0120162 ! positive regulation of cold-induced thermogenesis
- GO:0035360 ! positive regulation of peroxisome proliferator activated receptor signaling pathway
- GO:0014069 ! postsynaptic density
- GO:0045211 ! postsynaptic membrane
r
