MOUSE:ERN1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ern1 (ECO:0000312 with MGI:MGI:1930134) (synonyms: Ire1 (ECO:0000250 with UniProtKB:O75460))
Protein Name(s)	Serine/threonine-protein kinase/endoribonuclease IRE1 Endoplasmic reticulum-to-nucleus signaling 1 Inositol-requiring protein 1 Ire1-alpha IRE1a Serine/threonine-protein kinase Endoribonuclease
External Links
UniProt	Q9EQY0
EMBL	AB031332 AK018505
CCDS	CCDS25556.1
RefSeq	NP_076402.1
UniGene	Mm.340943
PDB	4PL3 4PL4 4PL5
PDBsum	4PL3 4PL4 4PL5
ProteinModelPortal	Q9EQY0
SMR	Q9EQY0
BioGrid	219724
IntAct	Q9EQY0
MINT	MINT-2631281
MaxQB	Q9EQY0
PaxDb	Q9EQY0
PRIDE	Q9EQY0
DNASU	78943
Ensembl	ENSMUST00000001059 ENSMUST00000106801
GeneID	78943
KEGG	mmu:78943
UCSC	uc007lyy.1
CTD	2081
MGI	MGI:1930134
eggNOG	COG0515
GeneTree	ENSGT00390000015684
HOGENOM	HOG000012929
HOVERGEN	HBG051506
InParanoid	Q9EQY0
KO	K08852
OMA	YVWQREG
OrthoDB	EOG7C2R0H
PhylomeDB	Q9EQY0
TreeFam	TF313986
Reactome	REACT_231085
NextBio	349824
PRO	PR:Q9EQY0
Proteomes	UP000000589
Bgee	Q9EQY0
ExpressionAtlas	Q9EQY0
Genevestigator	Q9EQY0
GO	GO:0005789 GO:0030176 GO:0005739 GO:0005637 GO:0005524 GO:0004519 GO:0004521 GO:0000287 GO:0004674 GO:0006987 GO:0007050 GO:0030968 GO:0070055 GO:0070059 GO:0070054 GO:1900103 GO:0033120 GO:0046777 GO:0006468 GO:0006355 GO:0006351
Gene3D	2.140.10.10
InterPro	IPR010513 IPR011009 IPR018391 IPR000719 IPR006567 IPR027295 IPR011047 IPR008271
Pfam	PF00069 PF06479
SMART	SM00564 SM00580
SUPFAM	SSF50998 SSF56112
PROSITE	PS51392 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0036498	IRE1-mediated unfolded protein response	PMID:25164867^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:25164867^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:25164867^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006379	mRNA cleavage	PMID:25164867^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:25164867^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033120	positive regulation of RNA splicing	PMID:25164867^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:25164867^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity	PMID:10650002^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0034976)	Seeded From UniProt	complete
part_of	GO:1990597	AIP1-IRE1 complex	PMID:18281285^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q3UHC7	C	exists_during:(GO:0034976)	Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
involved_in	GO:0001935	endothelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:19328063^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033120	positive regulation of RNA splicing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
involved_in	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:11146108^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036498	IRE1-mediated unfolded protein response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
part_of	GO:0005637	nuclear inner membrane	PMID:11850408^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	PMID:11850408^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
part_of	GO:1990604	IRE1-TRAF2-ASK1 complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1349436 PANTHER:PTN000359335 UniProtKB:O75460	C		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1349436 MGI:MGI:1930134 PANTHER:PTN000359335	P		Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000359335 SGD:S000001121	F		Seeded From UniProt	complete
involved_in	GO:0036498	IRE1-mediated unfolded protein response	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261984 MGI:MGI:1930134 PANTHER:PTN000359335 PomBase:SPAC167.01 UniProtKB:O75460	P		Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261984 MGI:MGI:1930134 PANTHER:PTN000359335 PomBase:SPAC167.01 SGD:S000001121 TAIR:locus:2053928 UniProtKB:O75460 UniProtKB:Q4WKP8 UniProtKB:Q93VJ2 WB:WBGene00002147	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1349436 MGI:MGI:1930134 PANTHER:PTN000359335 SGD:S000001121 TAIR:locus:2053928 UniProtKB:O75460 UniProtKB:Q7XIT1	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930134 PANTHER:PTN000359335 SGD:S000001121 UniProtKB:O75460 UniProtKB:Q76MJ5	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1930134 PANTHER:PTN000359335 SGD:S000001121 UniProtKB:O75460 UniProtKB:Q76MJ5	F		Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261984 MGI:MGI:1930134 PANTHER:PTN000359335 PomBase:SPAC167.01 SGD:S000001121 TAIR:locus:2053928 UniProtKB:O75460 UniProtKB:Q4WKP8 UniProtKB:Q93VJ2	F		Seeded From UniProt	complete
part_of	GO:1990630	IRE1-RACK1-PP2A complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	C		Seeded From UniProt	complete
part_of	GO:1990604	IRE1-TRAF2-ASK1 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990579	peptidyl-serine trans-autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901142	insulin metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098787	mRNA cleavage involved in mRNA processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071333	cellular response to glucose stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:11146108^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1559716	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	PMID:11430819^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
enables	GO:0043531	ADP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036498	IRE1-mediated unfolded protein response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036289	peptidyl-serine autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035924	cellular response to vascular endothelial growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034620	cellular response to unfolded protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033120	positive regulation of RNA splicing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:15601821^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:11430819^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:10882126^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
part_of	GO:0030176	integral component of endoplasmic reticulum membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007257	activation of JUN kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:9755171^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:23028046^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:15601821^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001935	endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75460	F		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004521	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004521	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004521	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004521	P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004521	P		Seeded From UniProt	complete
part_of	GO:1990630	IRE1-RACK1-PP2A complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	C		Seeded From UniProt	complete
part_of	GO:1990604	IRE1-TRAF2-ASK1 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	C		Seeded From UniProt	complete
involved_in	GO:1990579	peptidyl-serine trans-autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
involved_in	GO:1901142	insulin metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
involved_in	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
involved_in	GO:0098787	mRNA cleavage involved in mRNA processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
involved_in	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
enables	GO:0043531	ADP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	F		Seeded From UniProt	complete
involved_in	GO:0036498	IRE1-mediated unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
involved_in	GO:0036289	peptidyl-serine autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
involved_in	GO:0034620	cellular response to unfolded protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
involved_in	GO:0033120	positive regulation of RNA splicing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	F		Seeded From UniProt	complete
part_of	GO:0030176	integral component of endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	F		Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	F		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	F		Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	F		Seeded From UniProt	complete
involved_in	GO:0001935	endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75460 ensembl:ENSP00000401445	F		Seeded From UniProt	complete
enables	GO:0004540	ribonuclease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010513	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010513	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0834	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Sanches, M et al. (2014) Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun 5 4202 PubMed GONUTS page
↑ Urano, F et al. (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287 664-6 PubMed GONUTS page
↑ Luo, D et al. (2008) AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. J. Biol. Chem. 283 11905-12 PubMed GONUTS page
↑ Lisbona, F et al. (2009) BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol. Cell 33 679-91 PubMed GONUTS page
↑ ^5.0 ^5.1 Miyoshi, K et al. (2000) Characterization of mouse Ire1 alpha: cloning, mRNA localization in the brain and functional analysis in a neural cell line. Brain Res. Mol. Brain Res. 85 68-76 PubMed GONUTS page
↑ ^6.0 ^6.1 Lee, K et al. (2002) IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 16 452-66 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 Harding, HP et al. (2001) Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol. Cell 7 1153-63 PubMed GONUTS page
↑ ^9.0 ^9.1 Marciniak, SJ et al. (2004) CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 18 3066-77 PubMed GONUTS page
↑ Harding, HP et al. (2000) Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol. Cell 5 897-904 PubMed GONUTS page
↑ Wang, XZ et al. (1998) Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 17 5708-17 PubMed GONUTS page
↑ Ha, SD et al. (2012) Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. Mol. Cell. Biol. 32 4846-60 PubMed GONUTS page

[PMID:25164867-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Sanches, M et al. (2014) Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun 5 4202 PubMed GONUTS page

[PMID:10650002-2] Urano, F et al. (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287 664-6 PubMed GONUTS page

[PMID:18281285-3] Luo, D et al. (2008) AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. J. Biol. Chem. 283 11905-12 PubMed GONUTS page

[PMID:19328063-4] Lisbona, F et al. (2009) BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol. Cell 33 679-91 PubMed GONUTS page

[PMID:11146108-5] 5.0 ^5.1 Miyoshi, K et al. (2000) Characterization of mouse Ire1 alpha: cloning, mRNA localization in the brain and functional analysis in a neural cell line. Brain Res. Mol. Brain Res. 85 68-76 PubMed GONUTS page

[PMID:11850408-6] 6.0 ^6.1 Lee, K et al. (2002) IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 16 452-66 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11430819-8] 8.0 ^8.1 Harding, HP et al. (2001) Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol. Cell 7 1153-63 PubMed GONUTS page

[PMID:15601821-9] 9.0 ^9.1 Marciniak, SJ et al. (2004) CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 18 3066-77 PubMed GONUTS page

[PMID:10882126-10] Harding, HP et al. (2000) Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol. Cell 5 897-904 PubMed GONUTS page

[PMID:9755171-11] Wang, XZ et al. (1998) Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 17 5708-17 PubMed GONUTS page

[PMID:23028046-12] Ha, SD et al. (2012) Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. Mol. Cell. Biol. 32 4846-60 PubMed GONUTS page

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