MOUSE:DDX5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ddx5 (synonyms: Tnz2)
Protein Name(s)	Probable ATP-dependent RNA helicase DDX5 DEAD box RNA helicase DEAD1 mDEAD1 DEAD box protein 5 RNA helicase p68
External Links
UniProt	Q61656
EMBL	X65627 AL603664
PIR	I48385
UniGene	Mm.491096
ProteinModelPortal	Q61656
SMR	Q61656
DIP	DIP-32293N
IntAct	Q61656
MINT	MINT-1549637
PhosphoSite	Q61656
MaxQB	Q61656
PaxDb	Q61656
PRIDE	Q61656
UCSC	uc007lzs.1
MGI	MGI:105037
eggNOG	COG0513
HOVERGEN	HBG015893
InParanoid	Q61656
ChiTaRS	Ddx5
PRO	PR:Q61656
Proteomes	UP000000589
CleanEx	MM_DDX5
Genevestigator	Q61656
GO	GO:0005730 GO:0005634 GO:0030529 GO:0005681 GO:0050681 GO:0005524 GO:0008026 GO:0030331 GO:0003723 GO:0003724 GO:0003713 GO:0003712 GO:0007623 GO:0001701 GO:0072332 GO:0006397 GO:0000122 GO:0043517 GO:0045944 GO:0045893 GO:0000381 GO:0060765 GO:0045667 GO:2001014 GO:0008380 GO:0006351
Gene3D	3.40.50.300
InterPro	IPR011545 IPR014001 IPR001650 IPR027417 IPR012587 IPR000629 IPR014014
Pfam	PF00270 PF00271 PF08061
SMART	SM00487 SM00490
SUPFAM	SSF52540
PROSITE	PS00039 PS51192 PS51194 PS51195

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0030521	androgen receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
involved_in	GO:0030520	intracellular estrogen receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
involved_in	GO:0000380	alternative mRNA splicing, via spliceosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
enables	GO:0043021	ribonucleoprotein complex binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	F		Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	F		Seeded From UniProt	complete
involved_in	GO:0000956	nuclear-transcribed mRNA catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
involved_in	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	PMID:23022728^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
involved_in	GO:0045445	myoblast differentiation	PMID:24910439^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	PMID:24910439^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061614	pri-miRNA transcription by RNA polymerase II	PMID:24910439^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	C		Seeded From UniProt	complete
involved_in	GO:0000380	alternative mRNA splicing, via spliceosome	PMID:24910439^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001014	regulation of skeletal muscle cell differentiation	PMID:17011493^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
involved_in	GO:0060765	regulation of androgen receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	F		Seeded From UniProt	complete
involved_in	GO:0045667	regulation of osteoblast differentiation	PMID:17960593^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	C		Seeded From UniProt	complete
enables	GO:0003724	RNA helicase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	F		Seeded From UniProt	complete
involved_in	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:18809582^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
part_of	GO:0071013	catalytic step 2 spliceosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	C		Seeded From UniProt	complete
enables	GO:0070878	primary miRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	F		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060765	regulation of androgen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	F		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619906	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15464984^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045069	regulation of viral genome replication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619906	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
enables	GO:0043021	ribonucleoprotein complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	F		Seeded From UniProt	complete
enables	GO:0036002	pre-mRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	F		Seeded From UniProt	complete
part_of	GO:0035770	ribonucleoprotein granule	PMID:26627310^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0035500	MH2 domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030521	androgen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030520	intracellular estrogen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030509	BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619906	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009299	mRNA transcription	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007623	circadian rhythm	PMID:22767893^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006606	protein import into nucleus	PMID:22665494^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:5440479	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15464984^[6]	ECO:0000305	curator inference used in manual assertion	GO:0003712	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619906	F		Seeded From UniProt	complete
enables	GO:0004004	ATP-dependent RNA helicase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619906	F		Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	F		Seeded From UniProt	complete
enables	GO:0003724	RNA helicase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22665494^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	PMID:15464984^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000956	nuclear-transcribed mRNA catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000380	alternative mRNA splicing, via spliceosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17844	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011545	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011545	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0508	P		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0005681	spliceosomal complex	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0747	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0507	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Dardenne, E et al. (2012) Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness. Nat. Struct. Mol. Biol. 19 1139-46 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Dardenne, E et al. (2014) RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation. Cell Rep 7 1900-13 PubMed GONUTS page
↑ Caretti, G et al. (2006) The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation. Dev. Cell 11 547-60 PubMed GONUTS page
↑ Jensen, ED et al. (2008) p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation. J. Cell. Biochem. 103 1438-51 PubMed GONUTS page
↑ Maggi, LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol. Cell. Biol. 28 7050-65 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Warner, DR et al. (2004) Functional interaction between Smad, CREB binding protein, and p68 RNA helicase. Biochem. Biophys. Res. Commun. 324 70-6 PubMed GONUTS page
↑ Berg, JM et al. (2015) JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron 88 1173-1191 PubMed GONUTS page
↑ Padmanabhan, K et al. (2012) Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science 337 599-602 PubMed GONUTS page
↑ ^9.0 ^9.1 Arun, G et al. (2012) mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells. Mol. Cell. Biol. 32 3140-52 PubMed GONUTS page

[PMID:23022728-1] Dardenne, E et al. (2012) Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness. Nat. Struct. Mol. Biol. 19 1139-46 PubMed GONUTS page

[PMID:24910439-2] 2.0 ^2.1 ^2.2 ^2.3 Dardenne, E et al. (2014) RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation. Cell Rep 7 1900-13 PubMed GONUTS page

[PMID:17011493-3] Caretti, G et al. (2006) The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation. Dev. Cell 11 547-60 PubMed GONUTS page

[PMID:17960593-4] Jensen, ED et al. (2008) p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation. J. Cell. Biochem. 103 1438-51 PubMed GONUTS page

[PMID:18809582-5] Maggi, LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol. Cell. Biol. 28 7050-65 PubMed GONUTS page

[PMID:15464984-6] 6.0 ^6.1 ^6.2 Warner, DR et al. (2004) Functional interaction between Smad, CREB binding protein, and p68 RNA helicase. Biochem. Biophys. Res. Commun. 324 70-6 PubMed GONUTS page

[PMID:26627310-7] Berg, JM et al. (2015) JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron 88 1173-1191 PubMed GONUTS page

[PMID:22767893-8] Padmanabhan, K et al. (2012) Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science 337 599-602 PubMed GONUTS page

[PMID:22665494-9] 9.0 ^9.1 Arun, G et al. (2012) mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells. Mol. Cell. Biol. 32 3140-52 PubMed GONUTS page

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MOUSE:DDX5

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