MOUSE:CTGF

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ctgf (synonyms: Ccn2, Fisp-12, Fisp12, Hcs24)
Protein Name(s)	Connective tissue growth factor CCN family member 2 Hypertrophic chondrocyte-specific protein 24 Protein FISP-12
External Links
UniProt	P29268
EMBL	M70641 M70642 M80263 AC099695 CH466540 BC006783
CCDS	CCDS23751.1
PIR	A40578
RefSeq	NP_034347.2
UniGene	Mm.390287
ProteinModelPortal	P29268
SMR	P29268
IntAct	P29268
STRING	10090.ENSMUSP00000020171
PhosphoSite	P29268
MaxQB	P29268
PaxDb	P29268
PRIDE	P29268
Ensembl	ENSMUST00000020171
GeneID	14219
KEGG	mmu:14219
UCSC	uc011xbr.1
CTD	1490
MGI	MGI:95537
eggNOG	ENOG410IH0W ENOG4111F77
GeneTree	ENSGT00760000119225
HOGENOM	HOG000231462
HOVERGEN	HBG000635
InParanoid	P29268
KO	K06827
OMA	KCIRTPR
OrthoDB	EOG7N8ZXB
TreeFam	TF326070
NextBio	285469
PRO	PR:P29268
Proteomes	UP000000589
CleanEx	MM_CTGF
ExpressionAtlas	P29268
Genevisible	P29268
GO	GO:0005938 GO:0005801 GO:0005829 GO:0005576 GO:0005615 GO:0005794 GO:0043231 GO:0048471 GO:0005578 GO:0008201 GO:0005178 GO:0008022 GO:0001525 GO:0001502 GO:0030154 GO:0016477 GO:0007267 GO:0007160 GO:0035988 GO:0061448 GO:0060401 GO:0071897 GO:0070278 GO:0008543 GO:0007229 GO:0035556 GO:0030324 GO:0060548 GO:0010629 GO:0010260 GO:0001503 GO:0060452 GO:0050867 GO:0045597 GO:0008284 GO:0032967 GO:0043280 GO:0070374 GO:0070318 GO:0010628 GO:0046330 GO:0051496 GO:0072593 GO:0001558 GO:0032330 GO:0043200 GO:0034059 GO:0032355 GO:0070542 GO:0009749 GO:0051385 GO:0043434 GO:0001894
InterPro	IPR006207 IPR006208 IPR009030 IPR000867 IPR012395 IPR017891 IPR000884 IPR001007
Pfam	PF00007 PF00219 PF00090 PF00093
PIRSF	PIRSF036495
SMART	SM00041 SM00121 SM00209 SM00214
SUPFAM	SSF57184 SSF82895
PROSITE	PS01185 PS01225 PS00222 PS51323 PS50092 PS01208 PS50184

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0014028	notochord formation	PMID:23839921^[1]	ECO:0000315			P		Figure 3. A/B, Figure 5.A.	complete CACAO 11549
part_of	GO:0005615	extracellular space	PMID:24006456^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002548)	Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000142748 RGD:621392	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95537 PANTHER:PTN000142748	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95537 PANTHER:PTN000142748	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88613 PANTHER:PTN000142748 RGD:620763	P		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88613 MGI:MGI:95537 PANTHER:PTN000142748 UniProtKB:P48745	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072593	reactive oxygen species metabolic process	PMID:19364818^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29279	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070318	positive regulation of G0 to G1 transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070278	extracellular matrix constituent secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061448	connective tissue development	PMID:23839921^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4949916	P	results_in_development_of:(EMAPA:32739)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060548	negative regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060452	positive regulation of cardiac muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060401	cytosolic calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29279	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050867	positive regulation of cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29279	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045597	positive regulation of cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29279	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035988	chondrocyte proliferation	PMID:18597638^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2663631	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032330	regulation of chondrocyte differentiation	PMID:18597638^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2663631	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:9184077^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:18213577^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2663631	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:15305294^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_acquisition_of_features_of:(CL:0000138)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	PMID:10082563^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:18597638^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2663631	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:9184077^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:9184077^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29279	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007229	integrin-mediated signaling pathway	PMID:10446209^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007229	integrin-mediated signaling pathway	PMID:10082563^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007160	cell-matrix adhesion	PMID:9184077^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	C		Seeded From UniProt	complete
part_of	GO:0005801	cis-Golgi network	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:1888698^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:10446209^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001968	fibronectin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621392	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001894	tissue homeostasis	PMID:23839921^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4949916	P	occurs_in:(EMAPA:32739)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:12736220^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2663631	P	has_participant:(EMAPA:32782)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:10446209^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:10082563^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001503	ossification	PMID:12736220^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2663631	P	has_participant:(EMAPA:17213)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001503	ossification	PMID:11237711^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001502	cartilage condensation	PMID:15305294^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29279 ensembl:ENSP00000356954	P		Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29279 ensembl:ENSP00000356954	P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29279 ensembl:ENSP00000356954	P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29279 ensembl:ENSP00000356954	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29279 ensembl:ENSP00000356954	F		Seeded From UniProt	complete
involved_in	GO:0070542	response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0070318	positive regulation of G0 to G1 transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0070278	extracellular matrix constituent secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0060452	positive regulation of cardiac muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0060401	cytosolic calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0051385	response to mineralocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0050867	positive regulation of cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	C		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0034059	response to anoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	C		Seeded From UniProt	complete
part_of	GO:0005801	cis-Golgi network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	C		Seeded From UniProt	complete
enables	GO:0001968	fibronectin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E9 ensembl:ENSRNOP00000020528	P		Seeded From UniProt	complete
enables	GO:0005520	insulin-like growth factor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000867	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000867	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0071897	DNA biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0237	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Bedore, J et al. (2013) Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2. Arthritis Rheum. 65 2634-44 PubMed GONUTS page
↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Juric, V et al. (2009) Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo. Mol. Cell. Biol. 29 3266-79 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Kawaki, H et al. (2008) Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage. J. Bone Miner. Res. 23 1751-64 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Kireeva, ML et al. (1997) Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development. Exp. Cell Res. 233 63-77 PubMed GONUTS page
↑ Baguma-Nibasheka, M & Kablar, B (2008) Pulmonary hypoplasia in the connective tissue growth factor (Ctgf) null mouse. Dev. Dyn. 237 485-93 PubMed GONUTS page
↑ ^8.0 ^8.1 Shimo, T et al. (2004) Expression and roles of connective tissue growth factor in Meckel's cartilage development. Dev. Dyn. 231 136-47 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Babic, AM et al. (1999) Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol. Cell. Biol. 19 2958-66 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Jedsadayanmata, A et al. (1999) Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3). J. Biol. Chem. 274 24321-7 PubMed GONUTS page
↑ Ryseck, RP et al. (1991) Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein. Cell Growth Differ. 2 225-33 PubMed GONUTS page
↑ ^12.0 ^12.1 Ivkovic, S et al. (2003) Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 130 2779-91 PubMed GONUTS page
↑ Nakanishi, T et al. (2001) Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism. Biochem. Biophys. Res. Commun. 281 678-81 PubMed GONUTS page

[PMID:23839921-1] 1.0 ^1.1 ^1.2 Bedore, J et al. (2013) Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2. Arthritis Rheum. 65 2634-44 PubMed GONUTS page

[PMID:24006456-2] Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19364818-4] Juric, V et al. (2009) Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo. Mol. Cell. Biol. 29 3266-79 PubMed GONUTS page

[PMID:18597638-5] 5.0 ^5.1 ^5.2 Kawaki, H et al. (2008) Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage. J. Bone Miner. Res. 23 1751-64 PubMed GONUTS page

[PMID:9184077-6] 6.0 ^6.1 ^6.2 ^6.3 Kireeva, ML et al. (1997) Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development. Exp. Cell Res. 233 63-77 PubMed GONUTS page

[PMID:18213577-7] Baguma-Nibasheka, M & Kablar, B (2008) Pulmonary hypoplasia in the connective tissue growth factor (Ctgf) null mouse. Dev. Dyn. 237 485-93 PubMed GONUTS page

[PMID:15305294-8] 8.0 ^8.1 Shimo, T et al. (2004) Expression and roles of connective tissue growth factor in Meckel's cartilage development. Dev. Dyn. 231 136-47 PubMed GONUTS page

[PMID:10082563-9] 9.0 ^9.1 ^9.2 Babic, AM et al. (1999) Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol. Cell. Biol. 19 2958-66 PubMed GONUTS page

[PMID:10446209-10] 10.0 ^10.1 ^10.2 Jedsadayanmata, A et al. (1999) Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3). J. Biol. Chem. 274 24321-7 PubMed GONUTS page

[PMID:1888698-11] Ryseck, RP et al. (1991) Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein. Cell Growth Differ. 2 225-33 PubMed GONUTS page

[PMID:12736220-12] 12.0 ^12.1 Ivkovic, S et al. (2003) Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 130 2779-91 PubMed GONUTS page

[PMID:11237711-13] Nakanishi, T et al. (2001) Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism. Biochem. Biophys. Res. Commun. 281 678-81 PubMed GONUTS page

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