GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:23839921
| Citation |
Bedore, J, Sha, W, McCann, MR, Liu, S, Leask, A and Séguin, CA (2013) Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2. Arthritis Rheum. 65:2634-44 |
|---|---|
| Abstract |
Currently, our ability to treat intervertebral disc (IVD) degeneration is hampered by an incomplete understanding of disc development and aging. The specific function of matricellular proteins, including CCN2, during these processes remains an enigma. The aim of this study was to determine the tissue-specific localization of CCN proteins and to characterize their role in IVD tissues during embryonic development and age-related degeneration by using a mouse model of notochord-specific CCN2 deletion. |
| Links |
PubMed Online version:10.1002/art.38075 |
| Keywords |
Aggrecans/physiology; Aging/physiology; Animals; Collagen Type I/physiology; Collagen Type II/physiology; Connective Tissue Growth Factor/deficiency; Connective Tissue Growth Factor/genetics; Disease Models, Animal; Embryonic Development/physiology; Female; Intervertebral Disc/embryology; Intervertebral Disc/pathology; Intervertebral Disc/physiopathology; Intervertebral Disc Degeneration/pathology; Intervertebral Disc Degeneration/physiopathology; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Notochord/embryology; Notochord/pathology; Notochord/physiopathology |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
MOUSE:CCN2 |
involved_in |
GO:0061448: connective tissue development |
ECO:0000315: mutant phenotype evidence used in manual assertion |
MGI:MGI:4949916 |
P |
|
Seeded From UniProt |
complete |
|
MOUSE:CCN2 |
involved_in |
GO:0001894: tissue homeostasis |
ECO:0000315: mutant phenotype evidence used in manual assertion |
MGI:MGI:4949916 |
P |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0001894: tissue homeostasis |
ECO:0000315: mutant phenotype evidence used in manual assertion |
MGI:MGI:4949916 |
P |
occurs_in:(EMAPA:32739) |
Seeded From UniProt |
complete | |
| GO:0014028: notochord formation |
ECO:0000315: |
P |
Figure 3. A/B, Figure 5.A. |
complete | ||||
|
acts_upstream_of_or_within |
GO:0061448: connective tissue development |
ECO:0000315: mutant phenotype evidence used in manual assertion |
MGI:MGI:4949916 |
P |
results_in_development_of:(EMAPA:32739) |
Seeded From UniProt |
complete | |
Notes
See also
References
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