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PMID:23839921

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Citation

Bedore, J, Sha, W, McCann, MR, Liu, S, Leask, A and Séguin, CA (2013) Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2. Arthritis Rheum. 65:2634-44

Abstract

Currently, our ability to treat intervertebral disc (IVD) degeneration is hampered by an incomplete understanding of disc development and aging. The specific function of matricellular proteins, including CCN2, during these processes remains an enigma. The aim of this study was to determine the tissue-specific localization of CCN proteins and to characterize their role in IVD tissues during embryonic development and age-related degeneration by using a mouse model of notochord-specific CCN2 deletion.

Links

PubMed Online version:10.1002/art.38075

Keywords

Aggrecans/physiology; Aging/physiology; Animals; Collagen Type I/physiology; Collagen Type II/physiology; Connective Tissue Growth Factor/deficiency; Connective Tissue Growth Factor/genetics; Disease Models, Animal; Embryonic Development/physiology; Female; Intervertebral Disc/embryology; Intervertebral Disc/pathology; Intervertebral Disc/physiopathology; Intervertebral Disc Degeneration/pathology; Intervertebral Disc Degeneration/physiopathology; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Notochord/embryology; Notochord/pathology; Notochord/physiopathology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:CCN2

involved_in

GO:0061448: connective tissue development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:4949916

P

  • RO:0002296:(EMAPA:32739)

Seeded From UniProt

complete

MOUSE:CCN2

involved_in

GO:0001894: tissue homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:4949916

P

Seeded From UniProt

complete

MOUSE:CTGF

acts_upstream_of_or_within

GO:0001894: tissue homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:4949916

P

occurs_in:(EMAPA:32739)

Seeded From UniProt

complete

MOUSE:CTGF

GO:0014028: notochord formation

ECO:0000315:

P

Figure 3. A/B, Figure 5.A.

complete
CACAO 11549

MOUSE:CTGF

acts_upstream_of_or_within

GO:0061448: connective tissue development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:4949916

P

results_in_development_of:(EMAPA:32739)

Seeded From UniProt

complete

Notes

See also

References

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