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MOUSE:CSEN
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Kcnip3 (synonyms: Csen, Dream, Kchip3) | |
| Protein Name(s) | Calsenilin
A-type potassium channel modulatory protein 3 DRE-antagonist modulator DREAM Kv channel-interacting protein 3 KChIP3 | |
| External Links | ||
| UniProt | Q9QXT8 | |
| EMBL | AF287732 AF287733 AF287737 AF287734 AF287735 AF287736 AF287737 AF287734 AF287735 AF287736 AF287737 AF287734 AF287735 AF287736 AF184624 AF274050 AF300870 BC026980 BC047139 BC057329 | |
| CCDS | CCDS16703.1 CCDS71139.1 | |
| RefSeq | NP_001104801.1 NP_001277934.1 NP_062763.2 | |
| UniGene | Mm.315292 | |
| PDB | 2JUL | |
| PDBsum | 2JUL | |
| DisProt | DP00291 | |
| ProteinModelPortal | Q9QXT8 | |
| SMR | Q9QXT8 | |
| BioGrid | 208000 | |
| MINT | MINT-193520 | |
| STRING | 10090.ENSMUSP00000028850 | |
| PhosphoSite | Q9QXT8 | |
| MaxQB | Q9QXT8 | |
| PRIDE | Q9QXT8 | |
| Ensembl | ENSMUST00000103215 | |
| GeneID | 56461 | |
| KEGG | mmu:56461 | |
| UCSC | uc008mfm.1 | |
| CTD | 30818 | |
| MGI | MGI:1929258 | |
| GeneTree | ENSGT00760000118820 | |
| HOVERGEN | HBG108179 | |
| InParanoid | Q9QXT8 | |
| TreeFam | TF318560 | |
| EvolutionaryTrace | Q9QXT8 | |
| NextBio | 312710 | |
| PRO | PR:Q9QXT8 | |
| Proteomes | UP000000589 | |
| Bgee | Q9QXT8 | |
| CleanEx | MM_KCNIP3 | |
| ExpressionAtlas | Q9QXT8 | |
| Genevestigator | Q9QXT8 | |
| GO | GO:0043679 GO:0005829 GO:0030425 GO:0005783 GO:0005794 GO:0005634 GO:0005886 GO:0032993 GO:0005509 GO:0048306 GO:0003677 GO:0005267 GO:0015459 GO:0008022 GO:0043565 GO:0005244 GO:0006915 GO:0048266 GO:0006886 GO:0000122 GO:0045892 GO:0006813 GO:0043523 GO:0048265 GO:0019233 GO:0006351 | |
| Gene3D | 1.10.238.10 | |
| InterPro | IPR011992 IPR018247 IPR002048 IPR028846 | |
| PANTHER | PTHR23055 | |
| Pfam | PF13499 | |
| SMART | SM00054 | |
| PROSITE | PS00018 PS50222 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001046 |
core promoter sequence-specific DNA binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
activated_by:(CHEBI:18420) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
activated_by:(CHEBI:29108) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0072659 |
protein localization to plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901379 |
regulation of potassium ion transmembrane transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0015459 |
potassium channel regulator activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0008076 |
voltage-gated potassium channel complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0048266 |
behavioral response to pain |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2679303 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048265 |
response to pain |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2179103 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044325 |
ion channel binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:70888 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043679 |
axon terminus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:70888 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:70888 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043523 |
regulation of neuron apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:70888 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:70888 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030424 |
axon |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:70888 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0019233 |
sensory perception of pain |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2179103 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0015459 |
potassium channel regulator activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:70888 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008022 |
protein C-terminus binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006886 |
intracellular protein transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:70888 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:70888 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2179103 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006813 |
potassium ion transport |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005267 |
potassium channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071805 |
potassium ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006813 |
potassium ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005244 |
voltage-gated ion channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034765 |
regulation of ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Osawa, M et al. (2005) Mg2+ and Ca2+ differentially regulate DNA binding and dimerization of DREAM. J. Biol. Chem. 280 18008-14 PubMed GONUTS page
- ↑ Marionneau, C et al. () Proteomic analyses of native brain K(V)4.2 channel complexes. Channels (Austin) 3 284-94 PubMed GONUTS page
- ↑ 3.0 3.1 Foeger, NC et al. (2012) Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization. J. Biol. Chem. 287 9640-50 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Norris, AJ et al. (2010) Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons. J. Neurosci. 30 13644-55 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Chang, JW et al. (2007) Neuronal vulnerability of CLN3 deletion to calcium-induced cytotoxicity is mediated by calsenilin. Hum. Mol. Genet. 16 317-26 PubMed GONUTS page
- ↑ Lilliehook, C et al. (2003) Altered Abeta formation and long-term potentiation in a calsenilin knock-out. J. Neurosci. 23 9097-106 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Cheng, HY et al. (2002) DREAM is a critical transcriptional repressor for pain modulation. Cell 108 31-43 PubMed GONUTS page
- ↑ 8.0 8.1 Spreafico, F et al. (2001) Mouse DREAM/calsenilin/KChIP3: gene structure, coding potential, and expression. Mol. Cell. Neurosci. 17 1-16 PubMed GONUTS page
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- GO:0005886 ! plasma membrane
- GO:0005267 ! potassium channel activity
- GO:0015459 ! potassium channel regulator activity
- GO:0006813 ! potassium ion transport
- GO:0071805 ! potassium ion transmembrane transport
- GO:0032993 ! protein-DNA complex
- GO:0042803 ! protein homodimerization activity
- GO:0072659 ! protein localization to plasma membrane
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