MOUSE:CRERF

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Crebrf
Protein Name(s)	CREB3 regulatory factor Luman recruitment factor LRF
External Links
UniProt	Q8CDG5
EMBL	AK020796 AK030092 AK044760 CT025550 BC113191 BC113192
CCDS	CCDS37516.1
RefSeq	NP_084146.1 XP_006525177.1 XP_006525178.1 XP_006525179.1 XP_006525180.1
UniGene	Mm.275414
PhosphoSite	Q8CDG5
PRIDE	Q8CDG5
Ensembl	ENSMUST00000062519
GeneID	77128
KEGG	mmu:77128
UCSC	uc008bej.1
CTD	153222
MGI	MGI:1924378
eggNOG	NOG85144
GeneTree	ENSGT00390000007125
HOGENOM	HOG000088620
HOVERGEN	HBG106858
InParanoid	Q8CDG5
OrthoDB	EOG7R2BJ4
PhylomeDB	Q8CDG5
TreeFam	TF330810
NextBio	346534
Proteomes	UP000000589
Bgee	Q8CDG5
CleanEx	MM_A930001N09RIK
ExpressionAtlas	Q8CDG5
Genevestigator	Q8CDG5
GO	GO:0005737 GO:0016604 GO:0043565 GO:0003700 GO:0042711 GO:1900102 GO:1900170 GO:0000122 GO:0032388 GO:1902213 GO:0045732 GO:0051222 GO:0034976 GO:0006986 GO:0006351 GO:0006810
InterPro	IPR004827
PROSITE	PS00036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:1900170	negative regulation of glucocorticoid mediated signaling pathway	PMID:23071095	ECO:0000315			P		Fig. 6C - GR (= glucocorticoid receptor) activates transcription of pMMTV-luc reporter, transcription activation occurred to a lesser extent when LRF was added - this indicates LRF reduces GR activity Fig. 6D - GR levels decreased in cell over time in the presence of LRF, increased over time in the presence of LRF - this indicates LRF degrades GR	complete CACAO 10163
involved_in	GO:1900170	negative regulation of glucocorticoid mediated signaling pathway	PMID:23071095	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900102	negative regulation of endoplasmic reticulum unfolded protein response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IUR6-1	P		Seeded From UniProt	complete
involved_in	GO:0051222	positive regulation of protein transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IUR6-1	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IUR6-1	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IUR6-1	P		Seeded From UniProt	complete
involved_in	GO:0032388	positive regulation of intracellular transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IUR6-1	P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IUR6-1	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IUR6-1	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8IUR6-1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902213	positive regulation of prolactin signaling pathway	PMID:23071095	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900170	negative regulation of glucocorticoid mediated signaling pathway	PMID:23071095	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900102	negative regulation of endoplasmic reticulum unfolded protein response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IUR6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051222	positive regulation of protein transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IUR6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IUR6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IUR6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042711	maternal behavior	PMID:23071095	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95824 MGI:MGI:97762	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042711	maternal behavior	PMID:23071095	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IUR6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032388	positive regulation of intracellular transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IUR6	P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	PMID:23071095	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IUR6	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IUR6	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IUR6	C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IUR6	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IUR6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IUR6	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IUR6 ensembl:ENSP00000296953	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IUR6 ensembl:ENSP00000296953	C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IUR6 ensembl:ENSP00000296953	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IUR6 ensembl:ENSP00000296953	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827	P		Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039165	P		Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0834	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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