MOUSE:CREB1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Creb1 (synonyms: Creb-1)
Protein Name(s)	Cyclic AMP-responsive element-binding protein 1 CREB-1 cAMP-responsive element-binding protein 1
External Links
UniProt	Q01147
EMBL	X67719 X67721 X67724 X67725 X67726 X67727 X67728 X67719 X67721 X67722 X67724 X67725 X67726 X67727 X67728 M95106
CCDS	CCDS15004.1 CCDS15005.1
PIR	S20955 S42699
RefSeq	NP_034082.1 NP_598589.2 XP_006495713.1 XP_006495714.1
UniGene	Mm.422634
PDB	1DH3
PDBsum	1DH3
ProteinModelPortal	Q01147
SMR	Q01147
BioGrid	198873
IntAct	Q01147
MINT	MINT-263062
PhosphoSite	Q01147
PaxDb	Q01147
PRIDE	Q01147
Ensembl	ENSMUST00000049932 ENSMUST00000087366 ENSMUST00000185594 ENSMUST00000190348
GeneID	12912
KEGG	mmu:12912
UCSC	uc007bgr.1
CTD	1385
MGI	MGI:88494
eggNOG	NOG300199
HOGENOM	HOG000007365
HOVERGEN	HBG011077
InParanoid	Q01147
KO	K05870
OMA	QXISTIA
OrthoDB	EOG72G18D
PhylomeDB	Q01147
TreeFam	TF106464
Reactome	REACT_188573 REACT_196588 REACT_196593 REACT_198242 REACT_198246 REACT_198248 REACT_205251 REACT_213852 REACT_215503 REACT_216520 REACT_218211 REACT_224314 REACT_237796
ChiTaRS	Creb1
EvolutionaryTrace	Q01147
NextBio	282540
PRO	PR:Q01147
Proteomes	UP000000589
Bgee	Q01147
CleanEx	MM_CREB1
ExpressionAtlas	Q01147
Genevestigator	Q01147
GO	GO:0000790 GO:0005654 GO:0005634 GO:0005667 GO:0003677 GO:0043565 GO:0003700 GO:0007409 GO:0071363 GO:0071294 GO:0007623 GO:0007595 GO:0060428 GO:0060430 GO:0030879 GO:0007613 GO:0021983 GO:0045600 GO:0046887 GO:0046889 GO:0040018 GO:0045672 GO:0045944 GO:0045893 GO:0006468 GO:0050821 GO:0008361 GO:0006355 GO:0042493 GO:0033762 GO:0010033 GO:0033363 GO:0006351 GO:0060509
InterPro	IPR004827 IPR003102 IPR029802 IPR001630
PANTHER	PTHR22952:SF104
Pfam	PF00170 PF02173
PRINTS	PR00041
SMART	SM00338
PROSITE	PS50217 PS00036 PS50953

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0000790	nuclear chromatin	PMID:20876357^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	PMID:20876357^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:20876357^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_regulation_target:(ENSEMBL:ENSMUSG00000038872) part_of:(GO:0071300)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20876357^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSMUSG00000038872) part_of:(GO:0071300)	Seeded From UniProt	complete
part_of	GO:1990589	ATF4-CREB1 transcription factor complex	PMID:12871976^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034976)	Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	PMID:16427017^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:16427017^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:21728997^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046889	positive regulation of lipid biosynthetic process	PMID:21728997^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q32M00	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20852621^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:21728997^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q32M00	P		Seeded From UniProt	complete
involved_in	GO:0045600	positive regulation of fat cell differentiation	PMID:21728997^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q32M00	P		Seeded From UniProt	complete
involved_in	GO:0033762	response to glucagon	PMID:20852621^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:20852621^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21728997^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1298366 MGI:MGI:88494 MGI:MGI:88495 PANTHER:PTN001119557 RGD:1307360 RGD:620218	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990830	cellular response to leukemia inhibitory factor	PMID:20439489^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1990763	arrestin family protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	F		Seeded From UniProt	complete
part_of	GO:1990589	ATF4-CREB1 transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900273	positive regulation of long-term synaptic potentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071294	cellular response to zinc ion	PMID:23716681^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060509	type I pneumocyte differentiation	PMID:21408140^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4999627	P	occurs_in:(EMAPA:17655) results_in_acquisition_of_features_of:(CL:0002062)\|occurs_in(EMAPA:17663) results_in_acquisition_of_features_of:(CL:0002062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060430	lung saccule development	PMID:21408140^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4999627	P	results_in_development_of:(EMAPA:19182)\|results_in_development_of:(EMAPA:19190)\|results_in_development_of:(EMAPA:19188)\|results_in_development_of:(EMAPA:19186)\|results_in_development_of:(EMAPA:19184)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060428	lung epithelium development	PMID:21408140^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4999627	P	results_in_development_of:(EMAPA:19182)\|results_in_development_of:(EMAPA:19190)\|results_in_development_of:(EMAPA:19188)\|results_in_development_of:(EMAPA:19186)\|results_in_development_of:(EMAPA:19184)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060251	regulation of glial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055025	positive regulation of cardiac muscle tissue development	PMID:24364879^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048145	regulation of fibroblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046887	positive regulation of hormone secretion	PMID:16141355^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:2181395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18252718^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:1923719)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8798441^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045672	positive regulation of osteoclast differentiation	PMID:23395171^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0002092)	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:15030764^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042752	regulation of circadian rhythm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	PMID:9098922^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16039)\|occurs_in:(EMAPA:16039)\|occurs_in:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040018	positive regulation of multicellular organism growth	PMID:16141355^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:2181395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035729	cellular response to hepatocyte growth factor stimulus	PMID:21072211^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035497	cAMP response element binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	F		Seeded From UniProt	complete
enables	GO:0035035	histone acetyltransferase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034670	chemotaxis to arachidonic acid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033363	secretory granule organization	PMID:21408140^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4999627	P	occurs_in:(EMAPA:17655) occurs_in:(CL:0002063)\|occurs_in:(EMAPA:17663) occurs_in:(CL:0002063)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032916	positive regulation of transforming growth factor beta3 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030879	mammary gland development	PMID:16141355^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:2181395	P	results_in_development_of:(EMAPA:36566)	Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021983	pituitary gland development	PMID:16141355^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:2181395	P	results_in_development_of:(EMAPA:35998)	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010944	negative regulation of transcription by competitive promoter binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010033	response to organic substance	PMID:8798441^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008542	visual learning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008361	regulation of cell size	PMID:12015964^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1332637	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	PMID:23223304^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:19037)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007595	lactation	PMID:16141355^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:2181395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007409	axonogenesis	PMID:11988169^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153538	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:8798441^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006366	transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12220541^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	C		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:11354513^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7565774^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21408140^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16728)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16251435^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15927180^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15817708^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14517290^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8798441^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19033670^[28]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15337	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12220541^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:8798441^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:14594818^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:11354513^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	F		Seeded From UniProt	complete
enables	GO:0001225	RNA polymerase II transcription coactivator binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16220	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620218	C		Seeded From UniProt	complete
enables	GO:1990763	arrestin family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
involved_in	GO:1990314	cellular response to insulin-like growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:1902065	response to L-glutamate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0071398	cellular response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0060251	regulation of glial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0048145	regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0036120	cellular response to platelet-derived growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
enables	GO:0035035	histone acetyltransferase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
involved_in	GO:0034670	chemotaxis to arachidonic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0032916	positive regulation of transforming growth factor beta3 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	C		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	P		Seeded From UniProt	complete
enables	GO:0001225	RNA polymerase II transcription coactivator binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15337 ensembl:ENSRNOP00000018326	C		Seeded From UniProt	complete
part_of	GO:1990589	ATF4-CREB1 transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	F		Seeded From UniProt	complete
enables	GO:0035497	cAMP response element binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	F		Seeded From UniProt	complete
involved_in	GO:0010944	negative regulation of transcription by competitive promoter binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	P		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16220 ensembl:ENSP00000387699	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U0J5 ensembl:ENSP00000387699	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001630	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001630 InterPro:IPR004827	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001630	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001630 InterPro:IPR003102 InterPro:IPR004827	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9022187 Reactome:R-MMU-9021925 Reactome:R-MMU-9021887 Reactome:R-MMU-9021848 Reactome:R-MMU-2976706	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Kim, TS et al. () The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Dis Model Mech 3 752-62 PubMed GONUTS page
↑ Luo, S et al. (2003) Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. J. Biol. Chem. 278 37375-85 PubMed GONUTS page
↑ ^3.0 ^3.1 Riccio, A et al. (2006) A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol. Cell 21 283-94 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Ma, X et al. (2011) CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes. Biochem. J. 439 27-38 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Zhang, EE et al. (2010) Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat. Med. 16 1152-6 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page
↑ Chowanadisai, W et al. (2013) Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12). Proc. Natl. Acad. Sci. U.S.A. 110 9903-8 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Bird, AD et al. (2011) cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development. PLoS ONE 6 e17843 PubMed GONUTS page
↑ Hao, J et al. (2014) Neuregulin-1β induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors. Biochem. J. 458 335-41 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Mantamadiotis, T et al. (2006) Hypothalamic 3',5'-cyclic adenosine monophosphate response element-binding protein loss causes anterior pituitary hypoplasia and dwarfism in mice. Mol. Endocrinol. 20 204-11 PubMed GONUTS page
↑ Reynolds, JG et al. (2008) Deregulated protein kinase A signaling and myospryn expression in muscular dystrophy. J. Biol. Chem. 283 8070-4 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Ji, L et al. (1996) CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas. J. Biol. Chem. 271 22687-91 PubMed GONUTS page
↑ Kim, H et al. (2013) Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. Cell Metab. 17 249-60 PubMed GONUTS page
↑ Bialek, P et al. (2004) A twist code determines the onset of osteoblast differentiation. Dev. Cell 6 423-35 PubMed GONUTS page
↑ Wlodarczyk, BC et al. (1996) Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology 54 284-97 PubMed GONUTS page
↑ Coudriet, GM et al. (2010) Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS ONE 5 e15384 PubMed GONUTS page
↑ Sordella, R et al. (2002) Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development. Dev. Cell 2 553-65 PubMed GONUTS page
↑ Sekeres, MJ et al. (2012) Increasing CRTC1 function in the dentate gyrus during memory formation or reactivation increases memory strength without compromising memory quality. J. Neurosci. 32 17857-68 PubMed GONUTS page
↑ Lonze, BE et al. (2002) Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron 34 371-85 PubMed GONUTS page
↑ ^21.0 ^21.1 Gong, P et al. (2002) Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. Arch. Biochem. Biophys. 405 265-74 PubMed GONUTS page
↑ ^22.0 ^22.1 Umesh, H et al. () Secalonic acid D alters the expression and phosphorylation of the transcription factors and their binding to cAMP response element in developing murine secondary palate. J. Craniofac. Genet. Dev. Biol. 20 173-82 PubMed GONUTS page
↑ Komada, M & Kitamura, N (1995) Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain. Mol. Cell. Biol. 15 6213-21 PubMed GONUTS page
↑ Moosmang, S et al. (2005) Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory. J. Neurosci. 25 9883-92 PubMed GONUTS page
↑ Catena, R et al. (2005) Proteolytic cleavage of ALF into alpha- and beta-subunits that form homologous and heterologous complexes with somatic TFIIA and TRF2 in male germ cells. FEBS Lett. 579 3401-10 PubMed GONUTS page
↑ Wilmanski, J et al. (2005) Augmented IL-10 production and redox-dependent signaling pathways in glucose-6-phosphate dehydrogenase-deficient mouse peritoneal macrophages. J. Leukoc. Biol. 78 85-94 PubMed GONUTS page
↑ Cullinan, SB et al. (2003) Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol. Cell. Biol. 23 7198-209 PubMed GONUTS page
↑ Takayanagi, Y et al. (2008) Endogenous prolactin-releasing peptide regulates food intake in rodents. J. Clin. Invest. 118 4014-24 PubMed GONUTS page
↑ Merluzzi, S et al. (2004) CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism. J. Biol. Chem. 279 1777-86 PubMed GONUTS page

[PMID:20876357-1] 1.0 ^1.1 ^1.2 ^1.3 Kim, TS et al. () The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Dis Model Mech 3 752-62 PubMed GONUTS page

[PMID:12871976-2] Luo, S et al. (2003) Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. J. Biol. Chem. 278 37375-85 PubMed GONUTS page

[PMID:16427017-3] 3.0 ^3.1 Riccio, A et al. (2006) A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol. Cell 21 283-94 PubMed GONUTS page

[PMID:21728997-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Ma, X et al. (2011) CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes. Biochem. J. 439 27-38 PubMed GONUTS page

[PMID:20852621-5] 5.0 ^5.1 ^5.2 Zhang, EE et al. (2010) Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat. Med. 16 1152-6 PubMed GONUTS page

[PMID:21873635-6] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20439489-7] Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page

[PMID:23716681-8] Chowanadisai, W et al. (2013) Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12). Proc. Natl. Acad. Sci. U.S.A. 110 9903-8 PubMed GONUTS page

[PMID:21408140-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Bird, AD et al. (2011) cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development. PLoS ONE 6 e17843 PubMed GONUTS page

[PMID:24364879-10] Hao, J et al. (2014) Neuregulin-1β induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors. Biochem. J. 458 335-41 PubMed GONUTS page

[PMID:16141355-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Mantamadiotis, T et al. (2006) Hypothalamic 3',5'-cyclic adenosine monophosphate response element-binding protein loss causes anterior pituitary hypoplasia and dwarfism in mice. Mol. Endocrinol. 20 204-11 PubMed GONUTS page

[PMID:18252718-12] Reynolds, JG et al. (2008) Deregulated protein kinase A signaling and myospryn expression in muscular dystrophy. J. Biol. Chem. 283 8070-4 PubMed GONUTS page

[PMID:8798441-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Ji, L et al. (1996) CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas. J. Biol. Chem. 271 22687-91 PubMed GONUTS page

[PMID:23395171-14] Kim, H et al. (2013) Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. Cell Metab. 17 249-60 PubMed GONUTS page

[PMID:15030764-15] Bialek, P et al. (2004) A twist code determines the onset of osteoblast differentiation. Dev. Cell 6 423-35 PubMed GONUTS page

[PMID:9098922-16] Wlodarczyk, BC et al. (1996) Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology 54 284-97 PubMed GONUTS page

[PMID:21072211-17] Coudriet, GM et al. (2010) Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS ONE 5 e15384 PubMed GONUTS page

[PMID:12015964-18] Sordella, R et al. (2002) Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development. Dev. Cell 2 553-65 PubMed GONUTS page

[PMID:23223304-19] Sekeres, MJ et al. (2012) Increasing CRTC1 function in the dentate gyrus during memory formation or reactivation increases memory strength without compromising memory quality. J. Neurosci. 32 17857-68 PubMed GONUTS page

[PMID:11988169-20] Lonze, BE et al. (2002) Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron 34 371-85 PubMed GONUTS page

[PMID:12220541-21] 21.0 ^21.1 Gong, P et al. (2002) Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. Arch. Biochem. Biophys. 405 265-74 PubMed GONUTS page

[PMID:11354513-22] 22.0 ^22.1 Umesh, H et al. () Secalonic acid D alters the expression and phosphorylation of the transcription factors and their binding to cAMP response element in developing murine secondary palate. J. Craniofac. Genet. Dev. Biol. 20 173-82 PubMed GONUTS page

[PMID:7565774-23] Komada, M & Kitamura, N (1995) Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain. Mol. Cell. Biol. 15 6213-21 PubMed GONUTS page

[PMID:16251435-24] Moosmang, S et al. (2005) Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory. J. Neurosci. 25 9883-92 PubMed GONUTS page

[PMID:15927180-25] Catena, R et al. (2005) Proteolytic cleavage of ALF into alpha- and beta-subunits that form homologous and heterologous complexes with somatic TFIIA and TRF2 in male germ cells. FEBS Lett. 579 3401-10 PubMed GONUTS page

[PMID:15817708-26] Wilmanski, J et al. (2005) Augmented IL-10 production and redox-dependent signaling pathways in glucose-6-phosphate dehydrogenase-deficient mouse peritoneal macrophages. J. Leukoc. Biol. 78 85-94 PubMed GONUTS page

[PMID:14517290-27] Cullinan, SB et al. (2003) Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol. Cell. Biol. 23 7198-209 PubMed GONUTS page

[PMID:19033670-28] Takayanagi, Y et al. (2008) Endogenous prolactin-releasing peptide regulates food intake in rodents. J. Clin. Invest. 118 4014-24 PubMed GONUTS page

[PMID:14594818-29] Merluzzi, S et al. (2004) CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism. J. Biol. Chem. 279 1777-86 PubMed GONUTS page

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MOUSE:CREB1

Contents

Annotations

Notes

References

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