MOUSE:COX41

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cox4i1 (synonyms: Cox4, Cox4a)
Protein Name(s)	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Cytochrome c oxidase polypeptide IV Cytochrome c oxidase subunit IV isoform 1 COX IV-1
External Links
UniProt	P19783
EMBL	X54691 M37831 M58034 M37829 AK012583 AK019276 AK150447
CCDS	CCDS40498.1
PIR	S12142
RefSeq	NP_001280488.1 NP_034071.2
UniGene	Mm.386758
ProteinModelPortal	P19783
SMR	P19783
BioGrid	198840
IntAct	P19783
MINT	MINT-1860013
STRING	10090.ENSMUSP00000034276
iPTMnet	P19783
PhosphoSitePlus	P19783
EPD	P19783
MaxQB	P19783
PaxDb	P19783
PeptideAtlas	P19783
PRIDE	P19783
TopDownProteomics	P19783
Ensembl	ENSMUST00000034276 ENSMUST00000181586
GeneID	12857
KEGG	mmu:12857
UCSC	uc009nrh.2
CTD	1327
MGI	MGI:88473
eggNOG	KOG4075 ENOG4111T97
GeneTree	ENSGT00390000002407
HOGENOM	HOG000231486
HOVERGEN	HBG051087
InParanoid	P19783
KO	K02263
OMA	EKHYVYG
OrthoDB	EOG091G0XDH
PhylomeDB	P19783
TreeFam	TF105061
ChiTaRS	Cox4i1
PRO	PR:P19783
Proteomes	UP000000589
Bgee	ENSMUSG00000031818
CleanEx	MM_COX4I1
ExpressionAtlas	P19783
Genevisible	P19783
GO	GO:0070062 GO:0016020 GO:0005743 GO:0031966 GO:0005751 GO:0005739 GO:0005634 GO:0004129 GO:0006123 GO:0007584
CDD	cd00922
InterPro	IPR013288 IPR004203
PANTHER	PTHR10707
Pfam	PF02936
PRINTS	PR01873
SUPFAM	SSF81406

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005743	mitochondrial inner membrane	PMID:20959514^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000076140 SGD:S000001373 SGD:S000004997 WB:WBGene00012354	P		Seeded From UniProt	complete
part_of	GO:0005751	mitochondrial respiratory chain complex IV	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000076140 SGD:S000001373 UniProtKB:P00423 UniProtKB:P13073	C		Seeded From UniProt	complete
contributes_to	GO:0004129	cytochrome-c oxidase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000076140 SGD:S000001373 SGD:S000004997 UniProtKB:P00423 UniProtKB:Q96KJ9	F		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	PMID:17923681^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005751	mitochondrial respiratory chain complex IV	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13073	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	PMID:12865426^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	PMID:12910269^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14651853^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:16894)\|part_of:(EMAPA:17373)\|part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:26767982^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:22783020^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:22555453^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17759)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:16103131^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:11940593^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13073	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13073	C		Seeded From UniProt	complete
involved_in	GO:1902600	proton transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004129	P		Seeded From UniProt	complete
involved_in	GO:1902600	proton transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004129	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10888 ensembl:ENSRNOP00000024033	P		Seeded From UniProt	complete
part_of	GO:0005751	mitochondrial respiratory chain complex IV	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13073 ensembl:ENSP00000457513	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13073 ensembl:ENSP00000457513	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13073 ensembl:ENSP00000457513	C		Seeded From UniProt	complete
enables	GO:0004129	cytochrome-c oxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004203 InterPro:IPR036639	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0999 UniProtKB-SubCell:SL-0168	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Strub, GM et al. (2011) Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. FASEB J. 25 600-12 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Lombard, DB et al. (2007) Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol. Cell. Biol. 27 8807-14 PubMed GONUTS page
↑ Da Cruz, S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J. Biol. Chem. 278 41566-71 PubMed GONUTS page
↑ Zhou, Z et al. (2003) Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat. Genet. 35 49-56 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
↑ Martin, J et al. (2016) Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein. Am. J. Physiol. Gastrointest. Liver Physiol. 310 G497-509 PubMed GONUTS page
↑ Somekawa, S et al. (2012) Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 109 12064-9 PubMed GONUTS page
↑ Arnandis, T et al. (2012) Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization. Cell Death Differ. 19 1536-48 PubMed GONUTS page
↑ Diaz, F et al. (2005) Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency. Hum. Mol. Genet. 14 2737-48 PubMed GONUTS page
↑ Carmona, MC et al. (2002) Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha. J. Biol. Chem. 277 21489-98 PubMed GONUTS page

[PMID:20959514-1] Strub, GM et al. (2011) Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. FASEB J. 25 600-12 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17923681-3] Lombard, DB et al. (2007) Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol. Cell. Biol. 27 8807-14 PubMed GONUTS page

[PMID:12865426-4] Da Cruz, S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J. Biol. Chem. 278 41566-71 PubMed GONUTS page

[PMID:12910269-5] Zhou, Z et al. (2003) Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat. Genet. 35 49-56 PubMed GONUTS page

[PMID:18614015-6] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:14651853-7] Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

[PMID:26767982-8] Martin, J et al. (2016) Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein. Am. J. Physiol. Gastrointest. Liver Physiol. 310 G497-509 PubMed GONUTS page

[PMID:22783020-9] Somekawa, S et al. (2012) Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 109 12064-9 PubMed GONUTS page

[PMID:22555453-10] Arnandis, T et al. (2012) Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization. Cell Death Differ. 19 1536-48 PubMed GONUTS page

[PMID:16103131-11] Diaz, F et al. (2005) Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency. Hum. Mol. Genet. 14 2737-48 PubMed GONUTS page

[PMID:11940593-12] Carmona, MC et al. (2002) Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha. J. Biol. Chem. 277 21489-98 PubMed GONUTS page

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MOUSE:COX41

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