MOUSE:CO1A1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Col1a1 (synonyms: Cola1)
Protein Name(s)	Collagen alpha-1(I) chain Alpha-1 type I collagen
External Links
UniProt	P11087
EMBL	U08020 AL662790 AL606480 AL606480 AL662790 BC050014 BC059281 K01688 S67530 S67482 X54876 M14423 M17491 K03036 K03029 K03030 K03031 K03032 K03033 K03034 K03035 X06753 X15896 X57981
CCDS	CCDS25265.1
PIR	I49558 S57243
RefSeq	NP_031768.2
UniGene	Mm.277735 Mm.458212
ProteinModelPortal	P11087
SMR	P11087
BioGrid	198831
IntAct	P11087
MINT	MINT-4091294
STRING	10090.ENSMUSP00000001547
PhosphoSite	P11087
MaxQB	P11087
PaxDb	P11087
PRIDE	P11087
Ensembl	ENSMUST00000001547
GeneID	12842
KEGG	mmu:12842
UCSC	uc007kzn.1
CTD	1277
MGI	MGI:88467
eggNOG	NOG12793
GeneTree	ENSGT00770000120467
HOVERGEN	HBG004933
InParanoid	P11087
KO	K06236
OMA	KNCPGAQ
OrthoDB	EOG7TJ3HH
PhylomeDB	P11087
TreeFam	TF344135
Reactome	REACT_196515 REACT_196581 REACT_196595 REACT_196606 REACT_196607 REACT_196644 REACT_198984 REACT_199046 REACT_199055 REACT_206066 REACT_216309 REACT_220092 REACT_225107 REACT_225233
ChiTaRS	Col1a1
NextBio	282376
PMAP-CutDB	P11087
PRO	PR:P11087
Proteomes	UP000000589
Bgee	P11087
CleanEx	MM_COL1A1
ExpressionAtlas	P11087
Genevestigator	P11087
GO	GO:0005581 GO:0005584 GO:0005737 GO:0005783 GO:0031012 GO:0005615 GO:0005794 GO:0005578 GO:0030141 GO:0005201 GO:0046872 GO:0001568 GO:0060346 GO:0060351 GO:0071230 GO:0071364 GO:0044344 GO:1902618 GO:0071260 GO:0071300 GO:0071560 GO:0071356 GO:0071306 GO:0032964 GO:0030199 GO:0048706 GO:0001958 GO:0060325 GO:0001957 GO:0010812 GO:0001649 GO:0090263 GO:0030335 GO:0010718 GO:0045893 GO:0070208 GO:0034504 GO:0015031 GO:0051591 GO:0031960 GO:0042493 GO:0032355 GO:0042542 GO:0055093 GO:0043434 GO:0007605 GO:0001501 GO:0048705 GO:0043588 GO:0043589 GO:0044691 GO:0034505 GO:0007601 GO:0042060
InterPro	IPR008160 IPR000885 IPR001007
Pfam	PF01410 PF01391 PF00093
ProDom	PD002078
SMART	SM00038 SM00214
PROSITE	PS51461 PS01208 PS50184

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28071719^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0000006)	Seeded From UniProt	complete
enables	GO:0030020	extracellular matrix structural constituent conferring tensile strength	PMID:28071719^[1]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0000006)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:22159717^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002048)\|part_of:(UBERON:0001155)	Seeded From UniProt	complete
enables	GO:0030020	extracellular matrix structural constituent conferring tensile strength	PMID:22159717^[2]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0002048)\|occurs_in:(UBERON:0001155)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:24006456^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002548)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:23658023^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	PMID:16311053^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:21625049^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043588	skin development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88467 PANTHER:PTN002771192	P		Seeded From UniProt	complete
involved_in	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002771192 RGD:61817	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88445 MGI:MGI:88446 MGI:MGI:88452 MGI:MGI:88453 MGI:MGI:88457 MGI:MGI:88467 PANTHER:PTN002513067	C		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1095415 MGI:MGI:2152695 MGI:MGI:2672118 MGI:MGI:88451 PANTHER:PTN002513067 WB:WBGene00001263 ZFIN:ZDB-GENE-030131-2281	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002771192 RGD:61817	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88467 PANTHER:PTN002771192 ZFIN:ZDB-GENE-030131-9102	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88452 MGI:MGI:88468 PANTHER:PTN002513067 RGD:61817 RGD:70936 RGD:727898 UniProtKB:P02452 UniProtKB:P02458 UniProtKB:P02461 UniProtKB:P08123 UniProtKB:Q9BXS0	C		Seeded From UniProt	complete
part_of	GO:0005584	collagen type I trimer	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88467 PANTHER:PTN002771192 UniProtKB:P02452	C		Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104687 MGI:MGI:2672118 MGI:MGI:88457 MGI:MGI:88467 PANTHER:PTN002513067 UniProtKB:P02461 UniProtKB:P02462 UniProtKB:P53420	F		Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88467 PANTHER:PTN002771192 UniProtKB:P02452	P		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002771192 RGD:61817	P		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88467 PANTHER:PTN002771192 UniProtKB:P02452 ZFIN:ZDB-GENE-030131-9102	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071230	cellular response to amino acid stimulus	PMID:20548288^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070208	protein heterotrimerization	PMID:9213002^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060351	cartilage development involved in endochondral bone morphogenesis	PMID:18248096^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3769585	P	results_in_development_of:(EMAPA:35503)\|results_in_development_of:(EMAPA:18028)\|results_in_development_of:(EMAPA:18010)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060346	bone trabecula formation	PMID:17440987^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97009	P	results_in_formation_of:(EMAPA:35503)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060325	face morphogenesis	PMID:17440987^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97009	P	has_participant:(EMAPA:35238)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048706	embryonic skeletal system development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048705	skeletal system morphogenesis	PMID:17440987^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97009	P	has_participant:(EMAPA:35456)	Seeded From UniProt	complete
enables	GO:0048407	platelet-derived growth factor binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043589	skin morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043588	skin development	PMID:18248096^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3769585	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042060	wound healing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	PMID:10970885^[12]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02454	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034505	tooth mineralization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034504	protein localization to nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032964	collagen biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:8984825^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17931)\|part_of:(EMAPA:16104)\|part_of:(EMAPA:17930)\|part_of:(EMAPA:17931)	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:8906420^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:7629088^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:7589890^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17760)	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:7573384^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000650)	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:2209468^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16728)\|part_of:(EMAPA:16728)\|part_of:(EMAPA:16728)	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:17029294^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17869)\|part_of:(EMAPA:17339)\|part_of:(EMAPA:17342)	Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:10878613^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030199	collagen fibril organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	P		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61817	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015031	protein transport	PMID:8906420^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010812	negative regulation of cell-substrate adhesion	PMID:17018525^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007601	visual perception	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61817	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61817	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:8018053^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32906) part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61817	C		Seeded From UniProt	complete
part_of	GO:0005584	collagen type I trimer	PMID:7790374^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857154	C	part_of:(EMAPA:36509)	Seeded From UniProt	complete
part_of	GO:0005584	collagen type I trimer	PMID:8018053^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32906)	Seeded From UniProt	complete
part_of	GO:0005584	collagen type I trimer	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	C		Seeded From UniProt	complete
part_of	GO:0005581	collagen trimer	PMID:14630726^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179405	C	part_of:(EMAPA:18601)	Seeded From UniProt	complete
part_of	GO:0005581	collagen trimer	PMID:8686743^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17525)	Seeded From UniProt	complete
part_of	GO:0005581	collagen trimer	PMID:7704020^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005581	collagen trimer	PMID:17662583^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005581	collagen trimer	PMID:15383546^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005581	collagen trimer	PMID:10608859^[29]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17527) part_of:(CL:0000057)	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:15383546^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001958	endochondral ossification	PMID:8130375^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001957	intramembranous ossification	PMID:17440987^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97009	P	has_participant:(EMAPA:35238)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:14630726^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179405	P	occurs_in:(EMAPA:18601)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001501	skeletal system development	PMID:8163675^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001501	skeletal system development	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P02452	P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P		Seeded From UniProt	complete
involved_in	GO:0048706	embryonic skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P		Seeded From UniProt	complete
enables	GO:0048407	platelet-derived growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P		Seeded From UniProt	complete
involved_in	GO:0043589	skin morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	F		Seeded From UniProt	complete
involved_in	GO:0034505	tooth mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P		Seeded From UniProt	complete
involved_in	GO:0032964	collagen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P		Seeded From UniProt	complete
involved_in	GO:0030199	collagen fibril organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P		Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	C		Seeded From UniProt	complete
part_of	GO:0005584	collagen type I trimer	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	C		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	F		Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02452 ensembl:ENSP00000225964	P		Seeded From UniProt	complete
involved_in	GO:1902618	cellular response to fluoride	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:1902617	response to fluoride	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0071306	cellular response to vitamin E	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0055093	response to hyperoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0048545	response to steroid hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0044691	tooth eruption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0044344	cellular response to fibroblast growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0031960	response to corticosteroid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	C		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	C		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02454 ensembl:ENSRNOP00000005311	P		Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000885	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-MMU-8985650	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005581	collagen trimer	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0176	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page
↑ ^2.0 ^2.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page
↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
↑ Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page
↑ Govoni, KE et al. (2006) Regulation of insulin-like growth factor binding protein-5, four and a half lim-2, and a disintegrin and metalloprotease-9 expression in osteoblasts. Growth Horm. IGF Res. 16 49-56 PubMed GONUTS page
↑ Scott, A et al. (2011) Mechanical force modulates scleraxis expression in bioartificial tendons. J Musculoskelet Neuronal Interact 11 124-32 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Pogribny, IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab. Invest. 90 1437-46 PubMed GONUTS page
↑ Balk, ML et al. (1997) Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim). Bone 21 7-15 PubMed GONUTS page
↑ ^10.0 ^10.1 Lisse, TS et al. (2008) ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta. PLoS Genet. 4 e7 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Egeblad, M et al. (2007) Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development. Dev. Dyn. 236 1683-93 PubMed GONUTS page
↑ Bhatt, RS et al. (2000) Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons. Genes Dev. 14 2216-28 PubMed GONUTS page
↑ Ohsaki, Y et al. (1995) Localization of types I and III collagen and fibronectin in the developing mouse palatal shelves. Acta Anat (Basel) 153 161-7 PubMed GONUTS page
↑ ^14.0 ^14.1 Iruela-Arispe, ML et al. (1996) Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: implications for fibroblast function. Dev. Dyn. 207 171-83 PubMed GONUTS page
↑ Lamandé, SR & Bateman, JF (1995) The type I collagen pro alpha 1(I) COOH-terminal propeptide N-linked oligosaccharide. Functional analysis by site-directed mutagenesis. J. Biol. Chem. 270 17858-65 PubMed GONUTS page
↑ Keely, PJ et al. (1995) The spatial and temporal expression of the alpha 2 beta 1 integrin and its ligands, collagen I, collagen IV, and laminin, suggest important roles in mouse mammary morphogenesis. Differentiation 59 1-13 PubMed GONUTS page
↑ He, CJ et al. (1995) Relationships between mesangial cell proliferation and types I and IV collagen mRNA levels in vitro. Am. J. Physiol. 269 C554-62 PubMed GONUTS page
↑ Heine, UI et al. (1990) Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis. Development 109 29-36 PubMed GONUTS page
↑ Lincoln, J et al. (2006) ColVa1 and ColXIa1 are required for myocardial morphogenesis and heart valve development. Dev. Dyn. 235 3295-305 PubMed GONUTS page
↑ Unda, FJ et al. (2000) Dissection of the odontoblast differentiation process in vitro by a combination of FGF1, FGF2, and TGFbeta1. Dev. Dyn. 218 480-9 PubMed GONUTS page
↑ Oganesian, A et al. (2006) The NH2-terminal propeptide of type I procollagen acts intracellularly to modulate cell function. J. Biol. Chem. 281 38507-18 PubMed GONUTS page
↑ ^22.0 ^22.1 Shroff, B et al. (1994) Dynamic variations in the expression of type I collagen and its molecular chaperone Hsp47 in cells of the mouse dental follicle during tooth eruption. Arch. Oral Biol. 39 231-43 PubMed GONUTS page
↑ Liu, X et al. (1995) A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J. Cell Biol. 130 227-37 PubMed GONUTS page
↑ ^24.0 ^24.1 Rahkonen, O et al. (2004) Mice with a deletion in the first intron of the Col1a1 gene develop age-dependent aortic dissection and rupture. Circ. Res. 94 83-90 PubMed GONUTS page
↑ Buck, M et al. (1996) Tumor necrosis factor-alpha inhibits collagen alpha1(I) gene expression and wound healing in a murine model of cachexia. Am. J. Pathol. 149 195-204 PubMed GONUTS page
↑ Andrikopoulos, K et al. (1995) Targeted mutation in the col5a2 gene reveals a regulatory role for type V collagen during matrix assembly. Nat. Genet. 9 31-6 PubMed GONUTS page
↑ Forlino, A et al. (2007) Selective retention and degradation of molecules with a single mutant alpha1(I) chain in the Brtl IV mouse model of OI. Matrix Biol. 26 604-14 PubMed GONUTS page
↑ ^28.0 ^28.1 Wenstrup, RJ et al. (2004) Type V collagen controls the initiation of collagen fibril assembly. J. Biol. Chem. 279 53331-7 PubMed GONUTS page
↑ Forlino, A et al. (1999) Use of the Cre/lox recombination system to develop a non-lethal knock-in murine model for osteogenesis imperfecta with an alpha1(I) G349C substitution. Variability in phenotype in BrtlIV mice. J. Biol. Chem. 274 37923-31 PubMed GONUTS page
↑ Kratochwil, K et al. (1993) Restricted expression of Mov13 mutant alpha 1(I) collagen gene in osteoblasts and its consequences for bone development. Dev. Dyn. 198 273-83 PubMed GONUTS page
↑ Pereira, R et al. (1994) Phenotypic variability and incomplete penetrance of spontaneous fractures in an inbred strain of transgenic mice expressing a mutated collagen gene (COL1A1). J. Clin. Invest. 93 1765-9 PubMed GONUTS page

[PMID:28071719-1] 1.0 ^1.1 Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page

[PMID:22159717-2] 2.0 ^2.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page

[PMID:24006456-3] Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page

[PMID:23658023-4] Soteriou, D et al. (2013) Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J. Biol. Chem. 288 18716-31 PubMed GONUTS page

[PMID:16311053-5] Govoni, KE et al. (2006) Regulation of insulin-like growth factor binding protein-5, four and a half lim-2, and a disintegrin and metalloprotease-9 expression in osteoblasts. Growth Horm. IGF Res. 16 49-56 PubMed GONUTS page

[PMID:21625049-6] Scott, A et al. (2011) Mechanical force modulates scleraxis expression in bioartificial tendons. J Musculoskelet Neuronal Interact 11 124-32 PubMed GONUTS page

[PMID:21873635-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20548288-8] Pogribny, IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab. Invest. 90 1437-46 PubMed GONUTS page

[PMID:9213002-9] Balk, ML et al. (1997) Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim). Bone 21 7-15 PubMed GONUTS page

[PMID:18248096-10] 10.0 ^10.1 Lisse, TS et al. (2008) ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta. PLoS Genet. 4 e7 PubMed GONUTS page

[PMID:17440987-11] 11.0 ^11.1 ^11.2 ^11.3 Egeblad, M et al. (2007) Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development. Dev. Dyn. 236 1683-93 PubMed GONUTS page

[PMID:10970885-12] Bhatt, RS et al. (2000) Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons. Genes Dev. 14 2216-28 PubMed GONUTS page

[PMID:8984825-13] Ohsaki, Y et al. (1995) Localization of types I and III collagen and fibronectin in the developing mouse palatal shelves. Acta Anat (Basel) 153 161-7 PubMed GONUTS page

[PMID:8906420-14] 14.0 ^14.1 Iruela-Arispe, ML et al. (1996) Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: implications for fibroblast function. Dev. Dyn. 207 171-83 PubMed GONUTS page

[PMID:7629088-15] Lamandé, SR & Bateman, JF (1995) The type I collagen pro alpha 1(I) COOH-terminal propeptide N-linked oligosaccharide. Functional analysis by site-directed mutagenesis. J. Biol. Chem. 270 17858-65 PubMed GONUTS page

[PMID:7589890-16] Keely, PJ et al. (1995) The spatial and temporal expression of the alpha 2 beta 1 integrin and its ligands, collagen I, collagen IV, and laminin, suggest important roles in mouse mammary morphogenesis. Differentiation 59 1-13 PubMed GONUTS page

[PMID:7573384-17] He, CJ et al. (1995) Relationships between mesangial cell proliferation and types I and IV collagen mRNA levels in vitro. Am. J. Physiol. 269 C554-62 PubMed GONUTS page

[PMID:2209468-18] Heine, UI et al. (1990) Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis. Development 109 29-36 PubMed GONUTS page

[PMID:17029294-19] Lincoln, J et al. (2006) ColVa1 and ColXIa1 are required for myocardial morphogenesis and heart valve development. Dev. Dyn. 235 3295-305 PubMed GONUTS page

[PMID:10878613-20] Unda, FJ et al. (2000) Dissection of the odontoblast differentiation process in vitro by a combination of FGF1, FGF2, and TGFbeta1. Dev. Dyn. 218 480-9 PubMed GONUTS page

[PMID:17018525-21] Oganesian, A et al. (2006) The NH2-terminal propeptide of type I procollagen acts intracellularly to modulate cell function. J. Biol. Chem. 281 38507-18 PubMed GONUTS page

[PMID:8018053-22] 22.0 ^22.1 Shroff, B et al. (1994) Dynamic variations in the expression of type I collagen and its molecular chaperone Hsp47 in cells of the mouse dental follicle during tooth eruption. Arch. Oral Biol. 39 231-43 PubMed GONUTS page

[PMID:7790374-23] Liu, X et al. (1995) A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J. Cell Biol. 130 227-37 PubMed GONUTS page

[PMID:14630726-24] 24.0 ^24.1 Rahkonen, O et al. (2004) Mice with a deletion in the first intron of the Col1a1 gene develop age-dependent aortic dissection and rupture. Circ. Res. 94 83-90 PubMed GONUTS page

[PMID:8686743-25] Buck, M et al. (1996) Tumor necrosis factor-alpha inhibits collagen alpha1(I) gene expression and wound healing in a murine model of cachexia. Am. J. Pathol. 149 195-204 PubMed GONUTS page

[PMID:7704020-26] Andrikopoulos, K et al. (1995) Targeted mutation in the col5a2 gene reveals a regulatory role for type V collagen during matrix assembly. Nat. Genet. 9 31-6 PubMed GONUTS page

[PMID:17662583-27] Forlino, A et al. (2007) Selective retention and degradation of molecules with a single mutant alpha1(I) chain in the Brtl IV mouse model of OI. Matrix Biol. 26 604-14 PubMed GONUTS page

[PMID:15383546-28] 28.0 ^28.1 Wenstrup, RJ et al. (2004) Type V collagen controls the initiation of collagen fibril assembly. J. Biol. Chem. 279 53331-7 PubMed GONUTS page

[PMID:10608859-29] Forlino, A et al. (1999) Use of the Cre/lox recombination system to develop a non-lethal knock-in murine model for osteogenesis imperfecta with an alpha1(I) G349C substitution. Variability in phenotype in BrtlIV mice. J. Biol. Chem. 274 37923-31 PubMed GONUTS page

[PMID:8130375-30] Kratochwil, K et al. (1993) Restricted expression of Mov13 mutant alpha 1(I) collagen gene in osteoblasts and its consequences for bone development. Dev. Dyn. 198 273-83 PubMed GONUTS page

[PMID:8163675-31] Pereira, R et al. (1994) Phenotypic variability and incomplete penetrance of spontaneous fractures in an inbred strain of transgenic mice expressing a mutated collagen gene (COL1A1). J. Clin. Invest. 93 1765-9 PubMed GONUTS page

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MOUSE:CO1A1

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