MOUSE:CLOCK

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Clock
Protein Name(s)	Circadian locomoter output cycles protein kaput mCLOCK
External Links
UniProt	O08785
EMBL	AF000998 AF146793
CCDS	CCDS19360.1
RefSeq	NP_001276755.1 NP_031741.1 XP_006534807.1
UniGene	Mm.3552 Mm.392894
PDB	4F3L
PDBsum	4F3L
DisProt	DP00734
ProteinModelPortal	O08785
SMR	O08785
BioGrid	198756
DIP	DIP-30958N
IntAct	O08785
MINT	MINT-4654078
PhosphoSite	O08785
MaxQB	O08785
PaxDb	O08785
PRIDE	O08785
DNASU	12753
Ensembl	ENSMUST00000075159
GeneID	12753
KEGG	mmu:12753
UCSC	uc008xuq.1
CTD	9575
MGI	MGI:99698
eggNOG	NOG300360
GeneTree	ENSGT00760000118788
HOGENOM	HOG000234382
HOVERGEN	HBG050997
InParanoid	O08785
KO	K02223
OMA	TPINMQG
OrthoDB	EOG71G9T7
PhylomeDB	O08785
TreeFam	TF324568
Reactome	REACT_115781 REACT_198351 REACT_198352 REACT_198602 REACT_198620 REACT_226917 REACT_241925 REACT_24972
NextBio	282092
PRO	PR:O08785
Proteomes	UP000000589
Bgee	O08785
CleanEx	MM_CLOCK
ExpressionAtlas	O08785
Genevestigator	O08785
GO	GO:0033391 GO:0005694 GO:0005737 GO:0005829 GO:0005654 GO:0005634 GO:0005667 GO:0031490 GO:0001047 GO:0001046 GO:0003677 GO:0070888 GO:0004402 GO:0000978 GO:0000982 GO:0001077 GO:0001190 GO:0043565 GO:0003700 GO:0004871 GO:0008134 GO:0071479 GO:0032922 GO:0007623 GO:0000077 GO:0016573 GO:2000323 GO:0045892 GO:0050729 GO:0051092 GO:0045944 GO:0045893 GO:0043161 GO:0042634 GO:0050796 GO:0006355 GO:2000074 GO:0051775 GO:0007283 GO:0006366
Gene3D	4.10.280.10
InterPro	IPR011598 IPR001067 IPR001610 IPR000014 IPR013767
Pfam	PF00010 PF00989
PRINTS	PR00785
SMART	SM00353 SM00086 SM00091
SUPFAM	SSF47459 SSF55785
PROSITE	PS50888 PS50112

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Contributes to	GO:0016563	transcription activator activity	PMID:9616112^[1]	ECO:0000315			F		Fig 4B to 4D show CLOCK, BMAL1, and the mutant CLOCK delta 19 assayed at transcriptional activation sites in the luciferase reporter derived from the 5' flanking region of the mper1 gene. Transcriptional activator activity is present when only when both CLOCK and BMAL1 are present, and transcriptional activator activity is not present with the mutant CLOCK delta 19.	complete
	GO:0005634	nucleus	PMID:12897057^[2]	ECO:0000314			C		Fig. 1 SCN extracts obtained from C57BL/6J mice at designated circadian times were fractionated and analyzed by Western blotting using CLOCK antibodies	complete
	GO:0005737	cytoplasm	PMID:12897057^[2]	ECO:0000314			C		Fig. 1 SCN extracts obtained from C57BL/6J mice at designated circadian times were fractionated and analyzed by Western blotting using CLOCK antibodies	complete
	GO:0005667	transcription factor complex	PMID:9616112^[1]	ECO:0000316		UniProtKB:Q9WTL8	C		Fig 4B to 4D show CLOCK and BMAL1 assayed at transcriptional activation sites in the luciferase reporter derived from the 5' flanking region of the mper1 gene.	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:30012868^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:30012868^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:30012868^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:15147242^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15516	C		Seeded From UniProt	complete
involved_in	GO:0006473	protein acetylation	PMID:28985504^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:24043798^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:24051492^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:21113167^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22208286^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18662546^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19299583^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:19299583^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:19299583^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24089055^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:24089055^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20861012^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20861012^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:22894897^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:22894897^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:21768648^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:21768648^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:21768648^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:20106950^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15193144^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(ENSEMBL:ENSMUSG00000020893)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:14672706^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15147242^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:14672706^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:15147242^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:15560782^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:14672706^[18]	ECO:0000305	curator inference used in manual assertion	GO:0045944	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:15147242^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	PMID:24378737^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000074	regulation of type B pancreatic cell development	PMID:20562852^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:12738229^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:20430893^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:19605937^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051775	response to redox state	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15516	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:22895791^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	PMID:20562852^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20430893^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18316400^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12397359^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24736997^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12738229^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19605937^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:24378737^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21613214^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:23395176^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042634	regulation of hair cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15516	P		Seeded From UniProt	complete
part_of	GO:0033391	chromatoid body	PMID:22900038^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:18316400^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:23785138^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:20430893^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:19141540^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:22653727^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	PMID:24610784^[35]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:14645221^[36]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:22900038^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:22653727^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:22653727^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17310242^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	PMID:19141540^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:22653727^[34]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O15516	F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:24385426^[38]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071479	cellular response to ionizing radiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051775	response to redox state	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16606840^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096381	P	has_regulation_target:(MGI:MGI:1098283)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19217292^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620271	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042634	regulation of hair cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032922	circadian regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:11707566^[41]	ECO:0000247	sequence alignment evidence used in manual assertion	EMBL:AJ318057	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007623	circadian rhythm	PMID:8171325^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861634	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007623	circadian rhythm	PMID:12024206^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861634	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007623	circadian rhythm	PMID:12897057^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006473	protein acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12024206^[43]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	C		Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620271	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12897057^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620271	C		Seeded From UniProt	complete
part_of	GO:0005726	perichromatin fibrils	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620271	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:16606840^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12897057^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620271	C		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12024206^[43]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11707566^[41]	ECO:0000247	sequence alignment evidence used in manual assertion	EMBL:AJ318057	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000077	DNA damage checkpoint	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15516	P		Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004402	P		Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004402	P		Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004402	P		Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004402	P		Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004402	P		Seeded From UniProt	complete
involved_in	GO:0071479	cellular response to ionizing radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	F		Seeded From UniProt	complete
involved_in	GO:0051775	response to redox state	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	C		Seeded From UniProt	complete
involved_in	GO:0042634	regulation of hair cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	P		Seeded From UniProt	complete
involved_in	GO:0006473	protein acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	C		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	F		Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15516 ensembl:ENSP00000426983	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001067	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001067	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001067	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001067	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001067 InterPro:IPR013767	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.48	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-4568946 Reactome:R-MMU-5667072 Reactome:R-MMU-549451 Reactome:R-MMU-508656 Reactome:R-MMU-508619	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-8878686 Reactome:R-MMU-5669295 Reactome:R-MMU-5663189 Reactome:R-MMU-5663185 Reactome:R-MMU-5663172 Reactome:R-MMU-5663169 Reactome:R-MMU-5663161 Reactome:R-MMU-5663158 Reactome:R-MMU-5663147 Reactome:R-MMU-5663146 Reactome:R-MMU-5663129 Reactome:R-MMU-5663114 Reactome:R-MMU-508741 Reactome:R-MMU-508656	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	Reactome:R-NUL-4568946	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
enables	GO:0016746	transferase activity, transferring acyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0012	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Gekakis, N et al. (1998) Role of the CLOCK protein in the mammalian circadian mechanism. Science 280 1564-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Kondratov, RV et al. (2003) BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes Dev. 17 1921-32 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Nakashima, A et al. (2018) Dec1 and CLOCK Regulate Na/K-ATPase β1 Subunit Expression and Blood Pressure. Hypertension 72 746-754 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Hamaguchi, H et al. (2004) Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system. Biochem. J. 382 43-50 PubMed GONUTS page
↑ Lin, R et al. (2017) CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol. Cell 68 198-209.e6 PubMed GONUTS page
↑ Lande-Diner, L et al. (2013) A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery. Proc. Natl. Acad. Sci. U.S.A. 110 16021-6 PubMed GONUTS page
↑ Miki, T et al. (2013) p53 regulates Period2 expression and the circadian clock. Nat Commun 4 2444 PubMed GONUTS page
↑ Katada, S & Sassone-Corsi, P (2010) The histone methyltransferase MLL1 permits the oscillation of circadian gene expression. Nat. Struct. Mol. Biol. 17 1414-21 PubMed GONUTS page
↑ Devos, J et al. (2011) Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells. J Circadian Rhythms 9 12 PubMed GONUTS page
↑ Asher, G et al. (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134 317-28 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Ramsey, KM et al. (2009) Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 324 651-4 PubMed GONUTS page
↑ ^12.0 ^12.1 Li, DQ et al. (2013) Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun 4 2545 PubMed GONUTS page
↑ ^13.0 ^13.1 Ward, SM et al. (2010) The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. J. Biol. Chem. 285 38987-9000 PubMed GONUTS page
↑ ^14.0 ^14.1 Bellet, MM et al. (2012) The RelB subunit of NFκB acts as a negative regulator of circadian gene expression. Cell Cycle 11 3304-11 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Koyanagi, S et al. (2011) cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. J. Biol. Chem. 286 32416-23 PubMed GONUTS page
↑ Xu, CX et al. (2010) Disruption of CLOCK-BMAL1 transcriptional activity is responsible for aryl hydrocarbon receptor-mediated regulation of Period1 gene. Toxicol. Sci. 115 98-108 PubMed GONUTS page
↑ Li, Y et al. (2004) DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1. Biochem. J. 382 895-904 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Kawamoto, T et al. (2004) A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem. Biophys. Res. Commun. 313 117-24 PubMed GONUTS page
↑ Sato, F et al. (2004) Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. Eur. J. Biochem. 271 4409-19 PubMed GONUTS page
↑ ^20.0 ^20.1 Han, DH et al. (2014) Modulation of glucocorticoid receptor induction properties by core circadian clock proteins. Mol. Cell. Endocrinol. 383 170-80 PubMed GONUTS page
↑ ^21.0 ^21.1 Marcheva, B et al. (2010) Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 466 627-31 PubMed GONUTS page
↑ ^22.0 ^22.1 Schoenhard, JA et al. (2003) Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2. J. Mol. Cell. Cardiol. 35 473-81 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Doi, R et al. (2010) CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2. J. Biol. Chem. 285 22114-21 PubMed GONUTS page
↑ ^24.0 ^24.1 Sasaki, M et al. (2009) Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription. J. Biol. Chem. 284 25149-59 PubMed GONUTS page
↑ Spengler, ML et al. (2012) Core circadian protein CLOCK is a positive regulator of NF-κB-mediated transcription. Proc. Natl. Acad. Sci. U.S.A. 109 E2457-65 PubMed GONUTS page
↑ ^26.0 ^26.1 Bertolucci, C et al. (2008) Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators. Mol. Cell. Biol. 28 3070-5 PubMed GONUTS page
↑ Honma, S et al. (2002) Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature 419 841-4 PubMed GONUTS page
↑ Goriki, A et al. (2014) A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 12 e1001839 PubMed GONUTS page
↑ Ye, R et al. (2011) Biochemical analysis of the canonical model for the mammalian circadian clock. J. Biol. Chem. 286 25891-902 PubMed GONUTS page
↑ Li, MD et al. (2013) O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination. Cell Metab. 17 303-10 PubMed GONUTS page
↑ ^31.0 ^31.1 Peruquetti, RL et al. (2012) Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells. PLoS ONE 7 e42695 PubMed GONUTS page
↑ Baeza-Raja, B et al. (2013) p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J. Neurosci. 33 10221-34 PubMed GONUTS page
↑ ^33.0 ^33.1 Nader, N et al. (2009) Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications. FASEB J. 23 1572-83 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 ^34.3 Huang, N et al. (2012) Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science 337 189-94 PubMed GONUTS page
↑ Richards, J et al. (2014) A role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells. J. Biol. Chem. 289 11791-806 PubMed GONUTS page
↑ Curtis, AM et al. (2004) Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J. Biol. Chem. 279 7091-7 PubMed GONUTS page
↑ Zhao, WN et al. (2007) CIPC is a mammalian circadian clock protein without invertebrate homologues. Nat. Cell Biol. 9 268-75 PubMed GONUTS page
↑ Annayev, Y et al. (2014) Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. J. Biol. Chem. 289 5013-24 PubMed GONUTS page
↑ ^39.0 ^39.1 Yujnovsky, I et al. (2006) Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc. Natl. Acad. Sci. U.S.A. 103 6386-91 PubMed GONUTS page
↑ Duffield, GE et al. (2009) A role for Id2 in regulating photic entrainment of the mammalian circadian system. Curr. Biol. 19 297-304 PubMed GONUTS page
↑ ^41.0 ^41.1 Avivi, A et al. (2001) Biological clock in total darkness: the Clock/MOP3 circadian system of the blind subterranean mole rat. Proc. Natl. Acad. Sci. U.S.A. 98 13751-6 PubMed GONUTS page
↑ Vitaterna, MH et al. (1994) Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264 719-25 PubMed GONUTS page
↑ ^43.0 ^43.1 ^43.2 Cheng, MY et al. (2002) Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 417 405-10 PubMed GONUTS page

[PMID:9616112-1] 1.0 ^1.1 Gekakis, N et al. (1998) Role of the CLOCK protein in the mammalian circadian mechanism. Science 280 1564-9 PubMed GONUTS page

[PMID:12897057-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Kondratov, RV et al. (2003) BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes Dev. 17 1921-32 PubMed GONUTS page

[PMID:30012868-3] 3.0 ^3.1 ^3.2 Nakashima, A et al. (2018) Dec1 and CLOCK Regulate Na/K-ATPase β1 Subunit Expression and Blood Pressure. Hypertension 72 746-754 PubMed GONUTS page

[PMID:15147242-4] 4.0 ^4.1 ^4.2 ^4.3 Hamaguchi, H et al. (2004) Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system. Biochem. J. 382 43-50 PubMed GONUTS page

[PMID:28985504-5] Lin, R et al. (2017) CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol. Cell 68 198-209.e6 PubMed GONUTS page

[PMID:24043798-6] Lande-Diner, L et al. (2013) A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery. Proc. Natl. Acad. Sci. U.S.A. 110 16021-6 PubMed GONUTS page

[PMID:24051492-7] Miki, T et al. (2013) p53 regulates Period2 expression and the circadian clock. Nat Commun 4 2444 PubMed GONUTS page

[PMID:21113167-8] Katada, S & Sassone-Corsi, P (2010) The histone methyltransferase MLL1 permits the oscillation of circadian gene expression. Nat. Struct. Mol. Biol. 17 1414-21 PubMed GONUTS page

[PMID:22208286-9] Devos, J et al. (2011) Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells. J Circadian Rhythms 9 12 PubMed GONUTS page

[PMID:18662546-10] Asher, G et al. (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134 317-28 PubMed GONUTS page

[PMID:19299583-11] 11.0 ^11.1 ^11.2 Ramsey, KM et al. (2009) Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 324 651-4 PubMed GONUTS page

[PMID:24089055-12] 12.0 ^12.1 Li, DQ et al. (2013) Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun 4 2545 PubMed GONUTS page

[PMID:20861012-13] 13.0 ^13.1 Ward, SM et al. (2010) The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. J. Biol. Chem. 285 38987-9000 PubMed GONUTS page

[PMID:22894897-14] 14.0 ^14.1 Bellet, MM et al. (2012) The RelB subunit of NFκB acts as a negative regulator of circadian gene expression. Cell Cycle 11 3304-11 PubMed GONUTS page

[PMID:21768648-15] 15.0 ^15.1 ^15.2 Koyanagi, S et al. (2011) cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. J. Biol. Chem. 286 32416-23 PubMed GONUTS page

[PMID:20106950-16] Xu, CX et al. (2010) Disruption of CLOCK-BMAL1 transcriptional activity is responsible for aryl hydrocarbon receptor-mediated regulation of Period1 gene. Toxicol. Sci. 115 98-108 PubMed GONUTS page

[PMID:15193144-17] Li, Y et al. (2004) DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1. Biochem. J. 382 895-904 PubMed GONUTS page

[PMID:14672706-18] 18.0 ^18.1 ^18.2 Kawamoto, T et al. (2004) A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem. Biophys. Res. Commun. 313 117-24 PubMed GONUTS page

[PMID:15560782-19] Sato, F et al. (2004) Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. Eur. J. Biochem. 271 4409-19 PubMed GONUTS page

[PMID:24378737-20] 20.0 ^20.1 Han, DH et al. (2014) Modulation of glucocorticoid receptor induction properties by core circadian clock proteins. Mol. Cell. Endocrinol. 383 170-80 PubMed GONUTS page

[PMID:20562852-21] 21.0 ^21.1 Marcheva, B et al. (2010) Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 466 627-31 PubMed GONUTS page

[PMID:12738229-22] 22.0 ^22.1 Schoenhard, JA et al. (2003) Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2. J. Mol. Cell. Cardiol. 35 473-81 PubMed GONUTS page

[PMID:20430893-23] 23.0 ^23.1 ^23.2 Doi, R et al. (2010) CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2. J. Biol. Chem. 285 22114-21 PubMed GONUTS page

[PMID:19605937-24] 24.0 ^24.1 Sasaki, M et al. (2009) Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription. J. Biol. Chem. 284 25149-59 PubMed GONUTS page

[PMID:22895791-25] Spengler, ML et al. (2012) Core circadian protein CLOCK is a positive regulator of NF-κB-mediated transcription. Proc. Natl. Acad. Sci. U.S.A. 109 E2457-65 PubMed GONUTS page

[PMID:18316400-26] 26.0 ^26.1 Bertolucci, C et al. (2008) Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators. Mol. Cell. Biol. 28 3070-5 PubMed GONUTS page

[PMID:12397359-27] Honma, S et al. (2002) Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature 419 841-4 PubMed GONUTS page

[PMID:24736997-28] Goriki, A et al. (2014) A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 12 e1001839 PubMed GONUTS page

[PMID:21613214-29] Ye, R et al. (2011) Biochemical analysis of the canonical model for the mammalian circadian clock. J. Biol. Chem. 286 25891-902 PubMed GONUTS page

[PMID:23395176-30] Li, MD et al. (2013) O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination. Cell Metab. 17 303-10 PubMed GONUTS page

[PMID:22900038-31] 31.0 ^31.1 Peruquetti, RL et al. (2012) Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells. PLoS ONE 7 e42695 PubMed GONUTS page

[PMID:23785138-32] Baeza-Raja, B et al. (2013) p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J. Neurosci. 33 10221-34 PubMed GONUTS page

[PMID:19141540-33] 33.0 ^33.1 Nader, N et al. (2009) Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications. FASEB J. 23 1572-83 PubMed GONUTS page

[PMID:22653727-34] 34.0 ^34.1 ^34.2 ^34.3 Huang, N et al. (2012) Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science 337 189-94 PubMed GONUTS page

[PMID:24610784-35] Richards, J et al. (2014) A role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells. J. Biol. Chem. 289 11791-806 PubMed GONUTS page

[PMID:14645221-36] Curtis, AM et al. (2004) Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J. Biol. Chem. 279 7091-7 PubMed GONUTS page

[PMID:17310242-37] Zhao, WN et al. (2007) CIPC is a mammalian circadian clock protein without invertebrate homologues. Nat. Cell Biol. 9 268-75 PubMed GONUTS page

[PMID:24385426-38] Annayev, Y et al. (2014) Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. J. Biol. Chem. 289 5013-24 PubMed GONUTS page

[PMID:16606840-39] 39.0 ^39.1 Yujnovsky, I et al. (2006) Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc. Natl. Acad. Sci. U.S.A. 103 6386-91 PubMed GONUTS page

[PMID:19217292-40] Duffield, GE et al. (2009) A role for Id2 in regulating photic entrainment of the mammalian circadian system. Curr. Biol. 19 297-304 PubMed GONUTS page

[PMID:11707566-41] 41.0 ^41.1 Avivi, A et al. (2001) Biological clock in total darkness: the Clock/MOP3 circadian system of the blind subterranean mole rat. Proc. Natl. Acad. Sci. U.S.A. 98 13751-6 PubMed GONUTS page

[PMID:8171325-42] Vitaterna, MH et al. (1994) Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264 719-25 PubMed GONUTS page

[PMID:12024206-43] 43.0 ^43.1 ^43.2 Cheng, MY et al. (2002) Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 417 405-10 PubMed GONUTS page

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