GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:8171325
| Citation |
Vitaterna, MH, King, DP, Chang, AM, Kornhauser, JM, Lowrey, PL, McDonald, JD, Dove, WF, Pinto, LH, Turek, FW and Takahashi, JS (1994) Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264:719-25 |
|---|---|
| Abstract |
In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N-ethyl-N-nitrosourea (ENU) were screened for circadian clock mutations. A semidominant mutation, Clock, that lengthens circadian period and abolishes persistence of rhythmicity was identified. Clock segregated as a single gene that mapped to the midportion of mouse chromosome 5, a region syntenic to human chromosome 4. The power of ENU mutagenesis combined with the ability to clone murine genes by map position provides a generally applicable approach to study complex behavior in mammals. |
| Links | |
| Keywords |
Animals; Chromosome Mapping; Chromosomes, Human, Pair 4; Circadian Rhythm/genetics; Ethylnitrosourea; Female; Genes; Genotype; Humans; Male; Mice; Mice, Inbred C57BL; Mutagenesis; Phenotype |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
