MOUSE:CIDEA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cidea
Protein Name(s)	Cell death activator CIDE-A Cell death-inducing DFFA-like effector A
External Links
UniProt	O70302
EMBL	AF041376 AC154125 CH466528 CH466528 BC096649
CCDS	CCDS37846.1
RefSeq	NP_031728.2
UniGene	Mm.449
ProteinModelPortal	O70302
SMR	O70302
BioGrid	198712
IntAct	O70302
STRING	10090.ENSMUSP00000025404
PhosphoSite	O70302
PaxDb	O70302
PRIDE	O70302
Ensembl	ENSMUST00000025404
GeneID	12683
KEGG	mmu:12683
UCSC	uc012beh.1
CTD	1149
MGI	MGI:1270845
eggNOG	ENOG410IVIC ENOG4111SUV
GeneTree	ENSGT00390000018596
HOGENOM	HOG000029211
HOVERGEN	HBG050961
InParanoid	O70302
OMA	IRPLTFM
OrthoDB	EOG7K3TN6
TreeFam	TF334321
NextBio	281928
PRO	PR:O70302
Proteomes	UP000000589
Genevisible	O70302
GO	GO:0005737 GO:0005811 GO:0005740 GO:0005739 GO:0005634 GO:0042803 GO:0006915 GO:0008219 GO:0006629 GO:0019915 GO:0050710 GO:1900118 GO:0050995 GO:0030512 GO:0032720 GO:0010890 GO:1902510 GO:0006355 GO:0035634 GO:0001659 GO:0006351
InterPro	IPR003508
Pfam	PF02017
SMART	SM00266
PROSITE	PS51135

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:12910269^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902510	regulation of apoptotic DNA fragmentation	PMID:9564035^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900118	negative regulation of execution phase of apoptosis	PMID:17080483^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050995	negative regulation of lipid catabolic process	PMID:12910269^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:17080483^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PMID:17080483^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019915	lipid storage	PMID:12910269^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010890	positive regulation of sequestering of triglyceride	PMID:18509062^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000449)	Seeded From UniProt	complete
involved_in	GO:0008219	cell death	PMID:17080483^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005811	lipid droplet	PMID:18509062^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000449)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17080483^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17080483^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001659	temperature homeostasis	PMID:12910269^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035634	response to stilbenoid	PMID:17086191^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270845 PANTHER:PTN000959606 UniProtKB:O60543	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050995	negative regulation of lipid catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60543	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050710	negative regulation of cytokine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60543	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60543	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006629	lipid metabolic process	PMID:12910269^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2675505	P		Seeded From UniProt	complete
colocalizes_with	GO:0005811	lipid droplet	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60543	C		Seeded From UniProt	complete
part_of	GO:0005740	mitochondrial envelope	PMID:12910269^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:12910269^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050995	negative regulation of lipid catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60543 ensembl:ENSP00000320209	P		Seeded From UniProt	complete
involved_in	GO:0050710	negative regulation of cytokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60543 ensembl:ENSP00000320209	P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60543 ensembl:ENSP00000320209	P		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60543 ensembl:ENSP00000320209	C		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032936	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003508	P		Seeded From UniProt	complete
involved_in	GO:0019915	lipid storage	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032936	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0551 UniProtKB-SubCell:SL-0154	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Zhou, Z et al. (2003) Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat. Genet. 35 49-56 PubMed GONUTS page
↑ Inohara, N et al. (1998) CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 17 2526-33 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Iwahana, H et al. (2006) Glycoproteome profiling of transforming growth factor-beta (TGFbeta) signaling: nonglycosylated cell death-inducing DFF-like effector A inhibits TGFbeta1-dependent apoptosis. Proteomics 6 6168-80 PubMed GONUTS page
↑ ^4.0 ^4.1 Puri, V et al. (2008) Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc. Natl. Acad. Sci. U.S.A. 105 7833-8 PubMed GONUTS page
↑ Baur, JA et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444 337-42 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12910269-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Zhou, Z et al. (2003) Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat. Genet. 35 49-56 PubMed GONUTS page

[PMID:9564035-2] Inohara, N et al. (1998) CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 17 2526-33 PubMed GONUTS page

[PMID:17080483-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Iwahana, H et al. (2006) Glycoproteome profiling of transforming growth factor-beta (TGFbeta) signaling: nonglycosylated cell death-inducing DFF-like effector A inhibits TGFbeta1-dependent apoptosis. Proteomics 6 6168-80 PubMed GONUTS page

[PMID:18509062-4] 4.0 ^4.1 Puri, V et al. (2008) Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc. Natl. Acad. Sci. U.S.A. 105 7833-8 PubMed GONUTS page

[PMID:17086191-5] Baur, JA et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444 337-42 PubMed GONUTS page

[PMID:21873635-6] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:CIDEA

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