MOUSE:CFTR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cftr (synonyms: Abcc7)
Protein Name(s)	Cystic fibrosis transmembrane conductance regulator CFTR ATP-binding cassette sub-family C member 7 Channel conductance-controlling ATPase cAMP-dependent chloride channel
External Links
UniProt	P26361
EMBL	M69298 M60493 AF162137 L04873 S65942 S65940 S65941 S65942 S65941 S65940
CCDS	CCDS19930.1
PIR	A39901 A40303 I49593 I58115 I78527
RefSeq	NP_066388.1 XP_006505040.1 XP_006505041.1
UniGene	Mm.15621
PDB	1Q3H 1R0W 1R0X 1R0Y 1R0Z 1R10 1XF9 1XFA 3SI7
PDBsum	1Q3H 1R0W 1R0X 1R0Y 1R0Z 1R10 1XF9 1XFA 3SI7
ProteinModelPortal	P26361
SMR	P26361
BioGrid	198687
DIP	DIP-29618N
IntAct	P26361
MINT	MINT-2841263
PhosphoSite	P26361
PRIDE	P26361
DNASU	12638
Ensembl	ENSMUST00000045706 ENSMUST00000115405 ENSMUST00000140407
GeneID	12638
KEGG	mmu:12638
UCSC	uc009bai.1
CTD	1080
MGI	MGI:88388
eggNOG	COG1132
GeneTree	ENSGT00770000120479
HOGENOM	HOG000185880
HOVERGEN	HBG004169
InParanoid	P26361
KO	K05031
OMA	NALRRCF
OrthoDB	EOG7C2R0B
PhylomeDB	P26361
TreeFam	TF105200
BRENDA	3.6.3.49
Reactome	REACT_237882
ChiTaRS	Cftr
EvolutionaryTrace	P26361
NextBio	281830
PRO	PR:P26361
Proteomes	UP000000589
Bgee	P26361
ExpressionAtlas	P26361
Genevestigator	P26361
GO	GO:0016324 GO:0016323 GO:0009986 GO:0034707 GO:0030659 GO:0005769 GO:0031901 GO:0031205 GO:0070062 GO:0005902 GO:0005886 GO:0005524 GO:0015106 GO:0005260 GO:0005254 GO:0019869 GO:0015108 GO:0071320 GO:0032870 GO:1902476 GO:0006821 GO:0006695 GO:0030301 GO:0051454 GO:0015705 GO:0030324 GO:0060081 GO:0045909 GO:1902943 GO:0034097 GO:0042493 GO:0043627 GO:0043434 GO:0048240 GO:0030321 GO:0042311 GO:0006833
Gene3D	3.40.50.300
InterPro	IPR003593 IPR011527 IPR003439 IPR017871 IPR009147 IPR025837 IPR027417
PANTHER	PTHR24223:SF19
Pfam	PF00664 PF00005 PF14396
PRINTS	PR01851
SMART	SM00382
SUPFAM	SSF52540 SSF90123
TIGRFAMs	TIGR01271
PROSITE	PS50929 PS00211 PS50893

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:21884936^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34158	C		Seeded From UniProt	complete
involved_in	GO:0006904	vesicle docking involved in exocytosis	PMID:24885604^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000169) happens_during:(GO:0030073)	Seeded From UniProt	complete
involved_in	GO:0045921	positive regulation of exocytosis	PMID:24885604^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000169) happens_during:(GO:0030073)	Seeded From UniProt	complete
NOT\|involved_in	GO:0003254	regulation of membrane depolarization	PMID:24885604^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902161	positive regulation of cyclic nucleotide-gated ion channel activity	PMID:24885604^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000169) causally_upstream_of:(GO:0030073) has_regulation_target:(UniProtKB:Q8BHY3)	Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	PMID:24885604^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0000169)	Seeded From UniProt	complete
involved_in	GO:1902476	chloride transmembrane transport	PMID:24885604^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000169)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:24885604^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000169)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:24885604^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000169)	Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	PMID:24885604^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000169)	Seeded From UniProt	complete
involved_in	GO:0050891	multicellular organismal water homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	P		Seeded From UniProt	complete
involved_in	GO:0035377	transepithelial water transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	P		Seeded From UniProt	complete
involved_in	GO:0015701	bicarbonate transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	C		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	F		Seeded From UniProt	complete
enables	GO:0005260	intracellularly ATP-gated chloride channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	F		Seeded From UniProt	complete
involved_in	GO:1902476	chloride transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	P		Seeded From UniProt	complete
enables	GO:0015106	bicarbonate transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	F		Seeded From UniProt	complete
involved_in	GO:1904322	cellular response to forskolin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	P		Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	PMID:21976599^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060081	membrane hyperpolarization	PMID:21976599^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051454	intracellular pH elevation	PMID:21976599^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048240	sperm capacitation	PMID:21976599^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019869	chloride channel inhibitor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	F		Seeded From UniProt	complete
enables	GO:0015108	chloride transmembrane transporter activity	PMID:21976599^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015106	bicarbonate transmembrane transporter activity	PMID:21976599^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	C		Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	F		Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	PMID:20231442^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902476	chloride transmembrane transport	PMID:20231442^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:20231442^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902476	chloride transmembrane transport	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88388 PANTHER:PTN000658665 UniProtKB:P13569	P		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000657997 RGD:3112 SGD:S000002542 TAIR:locus:2061559 UniProtKB:A7KVC2 UniProtKB:Q10RX7	P		Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000657997 RGD:71101 TAIR:locus:2061559 UniProtKB:Q9LK64	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88388 PANTHER:PTN000658665 RGD:2332 UniProtKB:P13569	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352447 PANTHER:PTN000657997 RGD:2366 RGD:3112 RGD:620268 UniProtKB:O15439 UniProtKB:O15440	C		Seeded From UniProt	complete
involved_in	GO:0015701	bicarbonate transport	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000658665 RGD:2332 UniProtKB:P13569	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2443111 MGI:MGI:88388 PANTHER:PTN002384279 UniProtKB:O15439 UniProtKB:P13569	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88388 PANTHER:PTN000658665 UniProtKB:P13569	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000077	negative regulation of type B pancreatic cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905460	negative regulation of vascular associated smooth muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904446	positive regulation of establishment of Sertoli cell barrier	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904322	cellular response to forskolin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902943	positive regulation of voltage-gated chloride channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902476	chloride transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902161	positive regulation of cyclic nucleotide-gated ion channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	P		Seeded From UniProt	complete
enables	GO:0106138	Sec61 translocon complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	P		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	C		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050891	multicellular organismal water homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045921	positive regulation of exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042311	vasodilation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035377	transepithelial water transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033005	positive regulation of mast cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030321	transepithelial chloride transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030301	cholesterol transport	PMID:17085523^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856709	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	F		Seeded From UniProt	complete
enables	GO:0019869	chloride channel inhibitor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	F		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:16537650^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015705	iodide transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015701	bicarbonate transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015701	bicarbonate transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	P		Seeded From UniProt	complete
enables	GO:0015106	bicarbonate transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006821	chloride transport	PMID:19033647^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2385184	P	occurs_in:(EMAPA:17503) occurs_in:(CL:0002079)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006821	chloride transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006695	cholesterol biosynthetic process	PMID:17085523^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856709	P		Seeded From UniProt	complete
part_of	GO:0005902	microvillus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	C		Seeded From UniProt	complete
colocalizes_with	GO:0005769	early endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2332	C		Seeded From UniProt	complete
enables	GO:0005260	intracellularly ATP-gated chloride channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	F		Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P13569	F		Seeded From UniProt	complete
involved_in	GO:1904322	cellular response to forskolin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	P		Seeded From UniProt	complete
involved_in	GO:1902943	positive regulation of voltage-gated chloride channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	P		Seeded From UniProt	complete
involved_in	GO:1902476	chloride transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	P		Seeded From UniProt	complete
involved_in	GO:1902161	positive regulation of cyclic nucleotide-gated ion channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	P		Seeded From UniProt	complete
enables	GO:0106138	Sec61 translocon complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	F		Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	C		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	F		Seeded From UniProt	complete
involved_in	GO:0050891	multicellular organismal water homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	P		Seeded From UniProt	complete
involved_in	GO:0045921	positive regulation of exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	P		Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	P		Seeded From UniProt	complete
involved_in	GO:0035377	transepithelial water transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	C		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	F		Seeded From UniProt	complete
enables	GO:0019869	chloride channel inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	F		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	C		Seeded From UniProt	complete
involved_in	GO:0015701	bicarbonate transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	P		Seeded From UniProt	complete
enables	GO:0015106	bicarbonate transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	C		Seeded From UniProt	complete
enables	GO:0005260	intracellularly ATP-gated chloride channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	F		Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13569 ensembl:ENSP00000003084	F		Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009147	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003439 InterPro:IPR011527 InterPro:IPR017871 InterPro:IPR036640	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009147	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009147	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011527 InterPro:IPR036640	C		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003439 InterPro:IPR017871	F		Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011527	F		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011527	P		Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0413	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0034707	chloride channel complex	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0869	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0869	F		Seeded From UniProt	complete
involved_in	GO:0006821	chloride transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0869	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0055038	recycling endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0231	C		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gee, HY et al. (2011) Rescue of ΔF508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway. Cell 146 746-60 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Edlund, A et al. (2014) CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells. BMC Med 12 87 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Chávez, JC et al. (2012) Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation. Biol. Reprod. 86 1-14 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Lu, M et al. (2010) Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA-regulated apical chloride channels in cortical collecting duct. Proc. Natl. Acad. Sci. U.S.A. 107 6082-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 White, NM et al. (2007) Altered cholesterol homeostasis in cultured and in vivo models of cystic fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol. 292 L476-86 PubMed GONUTS page
↑ Yang, L et al. (2006) Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis. J. Cell. Sci. 119 1320-8 PubMed GONUTS page
↑ Yang, D et al. (2009) IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J. Clin. Invest. 119 193-202 PubMed GONUTS page

[PMID:21884936-1] Gee, HY et al. (2011) Rescue of ΔF508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway. Cell 146 746-60 PubMed GONUTS page

[PMID:24885604-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Edlund, A et al. (2014) CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells. BMC Med 12 87 PubMed GONUTS page

[PMID:21976599-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Chávez, JC et al. (2012) Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation. Biol. Reprod. 86 1-14 PubMed GONUTS page

[PMID:20231442-4] 4.0 ^4.1 ^4.2 Lu, M et al. (2010) Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA-regulated apical chloride channels in cortical collecting duct. Proc. Natl. Acad. Sci. U.S.A. 107 6082-7 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17085523-6] 6.0 ^6.1 White, NM et al. (2007) Altered cholesterol homeostasis in cultured and in vivo models of cystic fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol. 292 L476-86 PubMed GONUTS page

[PMID:16537650-7] Yang, L et al. (2006) Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis. J. Cell. Sci. 119 1320-8 PubMed GONUTS page

[PMID:19033647-8] Yang, D et al. (2009) IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J. Clin. Invest. 119 193-202 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

MOUSE:CFTR

Contents

Annotations

Notes

References

a

b

c

d

e

g

i

l

m

n

o

p

r

s

t

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools