MOUSE:CELR1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Celsr1
Protein Name(s)	Cadherin EGF LAG seven-pass G-type receptor 1
External Links
UniProt	O35161
EMBL	AF031572 AC116764 AC139513
CCDS	CCDS37172.1
PIR	T14119
RefSeq	NP_034016.2
UniGene	Mm.22680
ProteinModelPortal	O35161
IntAct	O35161
MINT	MINT-5312768
STRING	10090.ENSMUSP00000016172
PhosphoSite	O35161
MaxQB	O35161
PaxDb	O35161
PRIDE	O35161
Ensembl	ENSMUST00000016172
GeneID	12614
KEGG	mmu:12614
UCSC	uc007xdt.1
CTD	9620
MGI	MGI:1100883
eggNOG	NOG12793
GeneTree	ENSGT00760000118805
HOGENOM	HOG000231346
HOVERGEN	HBG050887
InParanoid	O35161
KO	K04600
OMA	EYERPYC
OrthoDB	EOG7BP81K
TreeFam	TF323983
ChiTaRS	Celsr1
NextBio	281774
PRO	PR:O35161
Proteomes	UP000000589
Bgee	O35161
Genevestigator	O35161
GO	GO:0005887 GO:0016020 GO:0005634 GO:0005509 GO:0004930 GO:0046983 GO:0004888 GO:0009952 GO:0045176 GO:0007267 GO:0007417 GO:0048105 GO:0001736 GO:0042249 GO:0007186 GO:0001702 GO:0001942 GO:0007156 GO:0042472 GO:0060490 GO:0007626 GO:0001843 GO:0001764 GO:0007218 GO:0060488 GO:0090179 GO:0060489 GO:0090251 GO:0032956 GO:0046928 GO:0007266 GO:0007165 GO:0042060
Gene3D	2.60.120.200 2.60.40.60
InterPro	IPR002126 IPR015919 IPR020894 IPR013320 IPR022624 IPR000742 IPR013032 IPR000152 IPR002049 IPR017981 IPR001879 IPR000832 IPR000203 IPR009030 IPR001791
Pfam	PF00002 PF00028 PF12003 PF00008 PF01825 PF02793 PF00053 PF02210
PRINTS	PR00205 PR00249
SMART	SM00112 SM00181 SM00180 SM00303 SM00008 SM00282
SUPFAM	SSF49313 SSF49899 SSF57184
PROSITE	PS00010 PS00232 PS50268 PS00022 PS01186 PS50026 PS01248 PS50027 PS50227 PS50261 PS50221 PS50025

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001764	neuron migration	PMID:20631168^[1]	ECO:0000315			P		Fig.2B,F,J,N Defective FBM neuron migration in Celsr1,2,3 KO mice	complete
NOT	GO:0021594	rhombomere formation	PMID:20631168^[1]	ECO:0000315			P		Fig.6 The specification of r3-r6 and rhombomeric borders appeared normal in all mutants studied.	complete
enables	GO:0046983	protein dimerization activity	PMID:9339365^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046928	regulation of neurotransmitter secretion	PMID:9339365^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:9339365^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:9339365^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:9339365^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:9339365^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:9339365^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	PMID:9339365^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001843	neural tube closure	PMID:12842012^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001736	establishment of planar polarity	PMID:12842012^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001702	gastrulation with mouth forming second	PMID:9339365^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090251	protein localization involved in establishment of planar polarity	PMID:18849982^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090179	planar cell polarity pathway involved in neural tube closure	PMID:20704721^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1918711 MGI:MGI:2135272	P	occurs_in:(EMAPA:16470)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060490	lateral sprouting involved in lung morphogenesis	PMID:20223754^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668337	P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060489	planar dichotomous subdivision of terminal units involved in lung branching morphogenesis	PMID:20223754^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668337	P	has_participant:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060488	orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis	PMID:20223754^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668337	P	has_participant:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048105	establishment of body hair planar orientation	PMID:19357712^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4430218	P	has_participant:(EMAPA:18769)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048105	establishment of body hair planar orientation	PMID:18849982^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668337	P	has_participant:(EMAPA:18771)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045176	apical protein localization	PMID:16687519^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668337	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:12842012^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1862019 MGI:MGI:2668337	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042249	establishment of planar polarity of embryonic epithelium	PMID:12842012^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1862019 MGI:MGI:2668337	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042060	wound healing	PMID:20643356^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1918711 MGI:MGI:2135272 MGI:MGI:2145950 MGI:MGI:2655333	P	occurs_in:(EMAPA:17528)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032956	regulation of actin cytoskeleton organization	PMID:20223754^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668337	P	regulates_o_occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:20353824^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:19357712^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4430218	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:18849982^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668337	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:10932191^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1862019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007266	Rho protein signal transduction	PMID:20223754^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668337	P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NYQ6	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NYQ6	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001942	hair follicle development	PMID:18849982^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668337	P	results_in_development_of:(EMAPA:18771)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001843	neural tube closure	PMID:17229766^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107926 MGI:MGI:2135272	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:20631168^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668337	P	occurs_in:(EMAPA:16916) results_in_movement_of:(CL:0000100)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NYQ6 ensembl:ENSP00000262738	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NYQ6 ensembl:ENSP00000262738	C		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000832 InterPro:IPR001879 InterPro:IPR036445	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001881 InterPro:IPR002126 InterPro:IPR015919	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020894	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020894	P		Seeded From UniProt	complete
involved_in	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002126	P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017981	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000832	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001879 InterPro:IPR002126 InterPro:IPR015919 InterPro:IPR036445	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000832 InterPro:IPR017981	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9339365^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:12842012^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Qu, Y et al. (2010) Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J. Neurosci. 30 9392-401 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Hadjantonakis, AK et al. (1997) Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter. Genomics 45 97-104 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Curtin, JA et al. (2003) Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr. Biol. 13 1129-33 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Devenport, D & Fuchs, E (2008) Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles. Nat. Cell Biol. 10 1257-68 PubMed GONUTS page
↑ Paudyal, A et al. (2010) The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear. BMC Dev. Biol. 10 87 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Yates, LL et al. (2010) The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. Hum. Mol. Genet. 19 2251-67 PubMed GONUTS page
↑ ^7.0 ^7.1 Ravni, A et al. (2009) Planar cell polarity cadherin Celsr1 regulates skin hair patterning in the mouse. J. Invest. Dermatol. 129 2507-9 PubMed GONUTS page
↑ Montcouquiol, M et al. (2006) Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J. Neurosci. 26 5265-75 PubMed GONUTS page
↑ Caddy, J et al. (2010) Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Dev. Cell 19 138-47 PubMed GONUTS page
↑ Formstone, CJ et al. (2010) Basal enrichment within neuroepithelia suggests novel function(s) for Celsr1 protein. Mol. Cell. Neurosci. 44 210-22 PubMed GONUTS page
↑ Nolan, PM et al. (2000) A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat. Genet. 25 440-3 PubMed GONUTS page
↑ Ybot-Gonzalez, P et al. (2007) Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development 134 789-99 PubMed GONUTS page

[PMID:20631168-1] 1.0 ^1.1 ^1.2 Qu, Y et al. (2010) Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J. Neurosci. 30 9392-401 PubMed GONUTS page

[PMID:9339365-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Hadjantonakis, AK et al. (1997) Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter. Genomics 45 97-104 PubMed GONUTS page

[PMID:12842012-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Curtin, JA et al. (2003) Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr. Biol. 13 1129-33 PubMed GONUTS page

[PMID:18849982-4] 4.0 ^4.1 ^4.2 ^4.3 Devenport, D & Fuchs, E (2008) Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles. Nat. Cell Biol. 10 1257-68 PubMed GONUTS page

[PMID:20704721-5] Paudyal, A et al. (2010) The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear. BMC Dev. Biol. 10 87 PubMed GONUTS page

[PMID:20223754-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Yates, LL et al. (2010) The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. Hum. Mol. Genet. 19 2251-67 PubMed GONUTS page

[PMID:19357712-7] 7.0 ^7.1 Ravni, A et al. (2009) Planar cell polarity cadherin Celsr1 regulates skin hair patterning in the mouse. J. Invest. Dermatol. 129 2507-9 PubMed GONUTS page

[PMID:16687519-8] Montcouquiol, M et al. (2006) Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J. Neurosci. 26 5265-75 PubMed GONUTS page

[PMID:20643356-9] Caddy, J et al. (2010) Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Dev. Cell 19 138-47 PubMed GONUTS page

[PMID:20353824-10] Formstone, CJ et al. (2010) Basal enrichment within neuroepithelia suggests novel function(s) for Celsr1 protein. Mol. Cell. Neurosci. 44 210-22 PubMed GONUTS page

[PMID:10932191-11] Nolan, PM et al. (2000) A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat. Genet. 25 440-3 PubMed GONUTS page

[PMID:17229766-12] Ybot-Gonzalez, P et al. (2007) Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development 134 789-99 PubMed GONUTS page

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MOUSE:CELR1

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