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PMID:18849982

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Citation

Devenport, D and Fuchs, E (2008) Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles. Nat. Cell Biol. 10:1257-68

Abstract

Mammalian body hairs align along the anterior-posterior (A-P) axis and offer a striking but poorly understood example of global cell polarization, a phenomenon known as planar cell polarity (PCP). We have discovered that during embryogenesis, marked changes in cell shape and cytoskeletal polarization occur as nascent hair follicles become anteriorly angled, morphologically polarized and molecularly compartmentalized along the A-P axis. Hair follicle initiation coincides with asymmetric redistribution of Vangl2, Celsr1 and Fzd6 within the embryonic epidermal basal layer. Moreover, loss-of-function mutations in Vangl2 and Celsr1 show that they have an essential role in hair follicle polarization and orientation, which develop in part through non-autonomous mechanisms. Vangl2 and Celsr1 are both required for their planar localization in vivo, and physically associate in a complex in vitro. Finally, we provide in vitro evidence that homotypic intracellular interactions of Celsr1 are required to recruit Vangl2 and Fzd6 to sites of cell-cell contact.

Links

PubMed PMC2607065 Online version:10.1038/ncb1784

Keywords

Animals; Body Patterning; Cell Polarity/genetics; Cells, Cultured; Embryo, Mammalian; Epidermis/embryology; Epidermis/metabolism; Frizzled Receptors/genetics; Frizzled Receptors/metabolism; Gene Expression; Hair/metabolism; Hair Follicle/metabolism; Immunohistochemistry; Keratinocytes/metabolism; Mice; Mice, Knockout; Mice, Mutant Strains; Morphogenesis; Mutation; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Receptors, G-Protein-Coupled/genetics; Receptors, G-Protein-Coupled/metabolism; Transfection

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:CELR1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:Q91ZD4

F

Seeded From UniProt

complete

MOUSE:CELR1

acts_upstream_of_or_within

GO:0001942: hair follicle development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2668337

P

  • results_in_development_of:(EMAPA:18771)

Seeded From UniProt

complete

MOUSE:CELR1

acts_upstream_of_or_within

GO:0009952: anterior/posterior pattern specification

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2668337

P

  • occurs_in:(EMAPA:18771)

Seeded From UniProt

complete

MOUSE:CELR1

acts_upstream_of_or_within

GO:0048105: establishment of body hair planar orientation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2668337

P

Seeded From UniProt

complete

MOUSE:VANG2

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:O35161

F

Seeded From UniProt

complete

MOUSE:VANG2

acts_upstream_of_or_within

GO:0001942: hair follicle development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857642

P

  • results_in_development_of:(EMAPA:18771)

Seeded From UniProt

complete

MOUSE:VANG2

acts_upstream_of_or_within

GO:0009952: anterior/posterior pattern specification

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857642

P

  • occurs_in:(EMAPA:18771)

Seeded From UniProt

complete

MOUSE:VANG2

acts_upstream_of_or_within

GO:0048105: establishment of body hair planar orientation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857642

P

Seeded From UniProt

complete

MOUSE:CELR1

acts_upstream_of_or_within

GO:0009952: anterior/posterior pattern specification

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2668337

P

Seeded From UniProt

complete

MOUSE:CELR1

acts_upstream_of_or_within

GO:0001942: hair follicle development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2668337

P

results_in_development_of:(EMAPA:18771)

Seeded From UniProt

complete

MOUSE:CELR1

acts_upstream_of_or_within

GO:0048105: establishment of body hair planar orientation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2668337

P

has_participant:(EMAPA:18771)

Seeded From UniProt

complete

MOUSE:CELR1

acts_upstream_of_or_within

GO:0090251: protein localization involved in establishment of planar polarity

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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