MOUSE:CDK5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cdk5 (synonyms: Cdkn5, Crk6)
Protein Name(s)	Cyclin-dependent-like kinase 5 CR6 protein kinase CRK6 Cell division protein kinase 5 Serine/threonine-protein kinase PSSALRE Tau protein kinase II catalytic subunit TPKII catalytic subunit
External Links
UniProt	P49615
EMBL	D29678 BC052007 X64604 S80121
CCDS	CCDS51434.1
PIR	I49592
RefSeq	NP_031694.1
UniGene	Mm.298798 Mm.445256
ProteinModelPortal	P49615
SMR	P49615
BioGrid	198646
DIP	DIP-29353N
IntAct	P49615
MINT	MINT-4090424
STRING	10090.ENSMUSP00000030814
PhosphoSite	P49615
MaxQB	P49615
PaxDb	P49615
PRIDE	P49615
Ensembl	ENSMUST00000030814
GeneID	12568
KEGG	mmu:12568
UCSC	uc008wrl.1
CTD	1020
MGI	MGI:101765
eggNOG	COG0515
HOGENOM	HOG000233024
HOVERGEN	HBG014652
InParanoid	P49615
KO	K02090
OMA	TMTKLPD
OrthoDB	EOG7966H8
PhylomeDB	P49615
TreeFam	TF101023
BRENDA	2.7.11.22
Reactome	REACT_198649 REACT_203795 REACT_244852
ChiTaRS	Cdk5
NextBio	281666
PRO	PR:P49615
Proteomes	UP000000589
Bgee	P49615
CleanEx	MM_CDK5
ExpressionAtlas	P49615
Genevestigator	P49615
GO	GO:0030424 GO:0030054 GO:0016533 GO:0005737 GO:0005829 GO:0030425 GO:0030175 GO:0030426 GO:0030027 GO:0016020 GO:0031594 GO:0043025 GO:0005634 GO:0043204 GO:0014069 GO:0045211 GO:0030549 GO:0005524 GO:0004693 GO:0005176 GO:0043125 GO:0016301 GO:0002039 GO:0004672 GO:0004674 GO:0050321 GO:0006915 GO:0008306 GO:0007409 GO:0048148 GO:0070509 GO:0007049 GO:0051301 GO:0016477 GO:0007160 GO:0021954 GO:0021695 GO:0021697 GO:0021549 GO:0021987 GO:0022038 GO:0030866 GO:0048813 GO:0009790 GO:0030900 GO:0021766 GO:0006886 GO:0021819 GO:0008045 GO:0030517 GO:0045786 GO:1901215 GO:0046826 GO:0031397 GO:0045861 GO:0031914 GO:0045892 GO:0051402 GO:0030182 GO:0001764 GO:0031175 GO:0006913 GO:0048709 GO:0018105 GO:0018107 GO:0045956 GO:0043525 GO:0032092 GO:0045860 GO:0090314 GO:2000273 GO:0046777 GO:0035418 GO:0006468 GO:0032801 GO:0043113 GO:0045055 GO:0030334 GO:0061001 GO:0060079 GO:0060078 GO:0048167 GO:0042220 GO:0009611 GO:0048511 GO:0014044 GO:0019233 GO:0033136 GO:0007519 GO:0007416 GO:0001963 GO:0035249 GO:0048488 GO:0021537 GO:0008542
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1903076	regulation of protein localization to plasma membrane	PMID:24607229^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q01097) regulates_o_occurs_in:(GO:0030425) regulates_o_occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:24607229^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q60829) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:24607229^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q01097) occurs_in:(UBERON:0002421) regulates:(GO:0072659)	Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	PMID:17517623^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11499	F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0061001	regulation of dendritic spine morphogenesis	PMID:17143272^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	F		Seeded From UniProt	complete
involved_in	GO:0048167	regulation of synaptic plasticity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	P		Seeded From UniProt	complete
enables	GO:0043125	ErbB-3 class receptor binding	PMID:11276227^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	C		Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	C		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	P		Seeded From UniProt	complete
enables	GO:0030549	acetylcholine receptor activator activity	PMID:11276227^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	C		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	C		Seeded From UniProt	complete
enables	GO:0005176	ErbB-2 class receptor binding	PMID:11276227^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03114	F		Seeded From UniProt	complete
involved_in	GO:0051966	regulation of synaptic transmission, glutamatergic	PMID:24607229^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0014548) regulates_o_occurs_in:(CL:0002608) regulates_o_occurs_in:(UBERON:0014548)	Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101765 PANTHER:PTN000623852 RGD:70514	P		Seeded From UniProt	complete
involved_in	GO:0048489	synaptic vesicle transport	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000623852 WB:WBGene00000407	P		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0013762 MGI:MGI:101765 PANTHER:PTN000623852	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004106 FB:FBgn0005640 FB:FBgn0013435 FB:FBgn0013762 FB:FBgn0015618 FB:FBgn0263237 MGI:MGI:101765 MGI:MGI:104772 MGI:MGI:88351 MGI:MGI:88357 PANTHER:PTN000623091 RGD:621124 RGD:70514 SGD:S000001622 SGD:S000001865 SGD:S000005488 SGD:S000005952 SGD:S000005963 SGD:S000006365 TAIR:locus:2119961 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P21127 UniProtKB:P24941 UniProtKB:P50750 UniProtKB:Q00534 UniProtKB:Q00646 UniProtKB:Q9UQ88 WB:WBGene00000405 WB:WBGene00000407 WB:WBGene00019362 ZFIN:ZDB-GENE-040808-34 dictyBase:DDB_G0267442 dictyBase:DDB_G0272813 dictyBase:DDB_G0288677	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101765 PANTHER:PTN000623703 UniProtKB:Q00535	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101765 MGI:MGI:894318 PANTHER:PTN002373304 RGD:70514 UniProtKB:Q00536 dictyBase:DDB_G0288677	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015618 FB:FBgn0019949 FB:FBgn0263237 MGI:MGI:101765 MGI:MGI:102956 MGI:MGI:104772 MGI:MGI:1328368 MGI:MGI:88353 MGI:MGI:88357 MGI:MGI:894318 PANTHER:PTN000623091 PomBase:SPAC2F3.15 PomBase:SPBC11B10.09 PomBase:SPBC32H8.10 RGD:1305435 RGD:1359638 RGD:2319 RGD:619874 RGD:621120 RGD:621124 RGD:70486 RGD:70514 SGD:S000000364 SGD:S000001622 SGD:S000002266 SGD:S000005952 TAIR:locus:2008595 TAIR:locus:2027819 TAIR:locus:2033349 TAIR:locus:2080290 TAIR:locus:2084086 TAIR:locus:2099478 TAIR:locus:2119961 TAIR:locus:2158554 TAIR:locus:2194045 UniProtKB:O76039 UniProtKB:O94921 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P21127 UniProtKB:P24941 UniProtKB:P49336 UniProtKB:P50613 UniProtKB:P61075 UniProtKB:P79432 UniProtKB:Q00534 UniProtKB:Q00535 UniProtKB:Q00646 UniProtKB:Q5B3E4 UniProtKB:Q8IDW1 UniProtKB:Q8IIL5 UniProtKB:Q8IJQ1 UniProtKB:Q8RWN3 UniProtKB:Q8W4P1 UniProtKB:Q92772 UniProtKB:Q96VK3 UniProtKB:Q9NYV4 UniProtKB:Q9UQ88 WB:WBGene00000405 dictyBase:DDB_G0267442 dictyBase:DDB_G0288677	C		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004106 FB:FBgn0005640 FB:FBgn0013762 FB:FBgn0019949 FB:FBgn0263237 MGI:MGI:104772 MGI:MGI:88351 MGI:MGI:88357 PANTHER:PTN000623091 PomBase:SPAC23H4.17c PomBase:SPAC2F3.15 PomBase:SPBC11B10.09 PomBase:SPBC19F8.07 PomBase:SPBC32H8.10 RGD:2319 RGD:621120 RGD:621124 RGD:70486 RGD:70514 SGD:S000000364 SGD:S000001622 SGD:S000005952 SGD:S000005963 SGD:S000006365 TAIR:locus:2011761 UniProtKB:A0A1D8PDA6 UniProtKB:C9K505 UniProtKB:O94921 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P24941 UniProtKB:P50750 UniProtKB:P61075 UniProtKB:Q00534 UniProtKB:Q00646 UniProtKB:Q8IJQ1 WB:WBGene00000405 ZFIN:ZDB-GENE-010131-2 dictyBase:DDB_G0272813 dictyBase:DDB_G0288677	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904646	cellular response to amyloid-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901216	positive regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00535	P		Seeded From UniProt	complete
enables	GO:0099635	voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	F		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098883	synapse pruning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090314	positive regulation of protein targeting to membrane	PMID:18054859^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4941830	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070509	calcium ion import	PMID:18054859^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:17529984^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3720892,MGI:MGI:3720937	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060078	regulation of postsynaptic membrane potential	PMID:16203963^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P	regulates_o_occurs_in:(EMAPA:17701) regulates_o_occurs_in:(CL:0000188)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	PMID:17591690^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048813	dendrite morphogenesis	PMID:17143272^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048813	dendrite morphogenesis	PMID:12372285^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048812	neuron projection morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048709	oligodendrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00535	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048488	synaptic vesicle endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048167	regulation of synaptic plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048148	behavioral response to cocaine	PMID:18032670^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3531299,MGI:MGI:3720892	P		Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046826	negative regulation of protein export from nucleus	PMID:17591690^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045956	positive regulation of calcium ion-dependent exocytosis	PMID:15123626^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00535	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045861	negative regulation of proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00535	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045860	positive regulation of protein kinase activity	PMID:16203963^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P	regulates_o_occurs_in:(EMAPA:35578) has_regulation_target:(MGI:MGI:95410)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045786	negative regulation of cell cycle	PMID:16237170^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045055	regulated exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043113	receptor clustering	PMID:16203963^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042501	serine phosphorylation of STAT protein	PMID:15096606^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042220	response to cocaine	PMID:14769920^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035418	protein localization to synapse	PMID:18054859^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035249	synaptic transmission, glutamatergic	PMID:14769920^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034352	positive regulation of glial cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032801	receptor catabolic process	PMID:17529984^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3720892,MGI:MGI:3720937	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	PMID:18054859^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4941830	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031914	negative regulation of synaptic plasticity	PMID:17529984^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3720892,MGI:MGI:3720937	P		Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031397	negative regulation of protein ubiquitination	PMID:17591690^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:17694053^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030866	cortical actin cytoskeleton organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030517	negative regulation of axon extension	PMID:22573681^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1197518	P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:3627430^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030334	regulation of cell migration	PMID:12941275^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:16237170^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:17202132^[20]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q00314	P		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	PMID:12496365^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00535	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:12496365^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022038	corpus callosum development	PMID:18032654^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928281,MGI:MGI:3043819	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021987	cerebral cortex development	PMID:9698328^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021954	central nervous system neuron development	PMID:8855328^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021819	layer formation in cerebral cortex	PMID:11517264^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021766	hippocampus development	PMID:11517264^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021697	cerebellar cortex formation	PMID:10407039^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021695	cerebellar cortex development	PMID:8855328^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021549	cerebellum development	PMID:11226314^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021537	telencephalon development	PMID:18032654^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928281,MGI:MGI:3043819	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019233	sensory perception of pain	PMID:17194758^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3042874,MGI:MGI:3043819	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018107	peptidyl-threonine phosphorylation	PMID:18054859^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	PMID:18054859^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179066 MGI:MGI:4941828	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	PMID:18054859^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00535	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016572	histone phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
part_of	GO:0016533	protein kinase 5 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	PMID:18032654^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928281,MGI:MGI:3043819	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	PMID:17694053^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	PMID:12496365^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016310	phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00535	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014044	Schwann cell development	PMID:16203963^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P	occurs_in:(EMAPA:17701) results_in_development_of:(CL:0000218)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009611	response to wounding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008542	visual learning	PMID:17529984^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3720892,MGI:MGI:3720937	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008306	associative learning	PMID:11978846^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008045	motor neuron axon guidance	PMID:16203963^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P	occurs_in:(EMAPA:17701) occurs_in:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007519	skeletal muscle tissue development	PMID:9191048^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007416	synapse assembly	PMID:18054859^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007409	axonogenesis	PMID:11163260^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007160	cell-matrix adhesion	PMID:12496365^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007005	mitochondrion organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	PMID:9126296^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006913	nucleocytoplasmic transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006887	exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006886	intracellular protein transport	PMID:8855328^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:17060449^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:894678	P	occurs_in:(EMAPA:16894) has_participant:(MGI:MGI:1932915)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:17591690^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:17194758^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:15489224^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:15123626^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:12372285^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:11517264^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:17202132^[20]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03114	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00535	C		Seeded From UniProt	complete
colocalizes_with	GO:0005874	microtubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:9202329^[35]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:12496365^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00535	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9191048^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:3627430^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15096606^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	C		Seeded From UniProt	complete
NOT\|part_of	GO:0005730	nucleolus	PMID:3627430^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9191048^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8891282^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17591690^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15096606^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00535	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	C		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18054859^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:15489224^[34]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12941275^[19]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:1924386)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00535	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:18054859^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179066 MGI:MGI:4941828	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:16203963^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	F	occurs_in:(EMAPA:35578) has_direct_input:(MGI:MGI:95410)\|occurs_in(EMAPA:35578) has_direct_input:(MGI:MGI:95411)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:14769920^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:9202329^[35]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:9126296^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:17194758^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:15123626^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:12372285^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:12077184^[37]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:11517264^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:11343650^[38]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:11226314^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:17202132^[20]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03114	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:17591690^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P02340	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001963	synaptic transmission, dopaminergic	PMID:14769920^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70514	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:15067135^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3043819,MGI:MGI:3043822	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:10407039^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861809	P		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0048488	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048488	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0099533	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0099533	C		Seeded From UniProt	complete
involved_in	GO:0099533	positive regulation of presynaptic cytosolic calcium concentration	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0099635	P		Seeded From UniProt	complete
involved_in	GO:0099533	positive regulation of presynaptic cytosolic calcium concentration	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099635	P		Seeded From UniProt	complete
involved_in	GO:0099703	induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0099635	P		Seeded From UniProt	complete
involved_in	GO:0099703	induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099635	P		Seeded From UniProt	complete
involved_in	GO:2000273	positive regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030549	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00535 ensembl:ENSP00000419782	P		Seeded From UniProt	complete
involved_in	GO:0048709	oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00535 ensembl:ENSP00000419782	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00535 ensembl:ENSP00000419782	P		Seeded From UniProt	complete
involved_in	GO:0045861	negative regulation of proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00535 ensembl:ENSP00000419782	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00535 ensembl:ENSP00000419782	C		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00535 ensembl:ENSP00000419782	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00535 ensembl:ENSP00000419782	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00535 ensembl:ENSP00000419782	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00535 ensembl:ENSP00000419782	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00535 ensembl:ENSP00000419782	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00535 ensembl:ENSP00000419782	F		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
enables	GO:0099635	voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	F		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	C		Seeded From UniProt	complete
involved_in	GO:0098883	synapse pruning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	C		Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	F		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
involved_in	GO:0048167	regulation of synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
involved_in	GO:0045055	regulated exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	C		Seeded From UniProt	complete
involved_in	GO:0034352	positive regulation of glial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	C		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
involved_in	GO:0030866	cortical actin cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	C		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
involved_in	GO:0016572	histone phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
part_of	GO:0016533	protein kinase 5 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	C		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	F		Seeded From UniProt	complete
involved_in	GO:0007519	skeletal muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
involved_in	GO:0006913	nucleocytoplasmic transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
involved_in	GO:0006887	exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	C		Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03114 ensembl:ENSRNOP00000011052	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A090N7W4 ensembl:ENSP00000419782	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A090N7W4 ensembl:ENSP00000419782	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A090N7W4 ensembl:ENSP00000419782	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A090N7W4 ensembl:ENSP00000419782	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-8870566 Reactome:R-NUL-421136 Reactome:R-MMU-8868677 Reactome:R-MMU-8868589 Reactome:R-MMU-8868583 Reactome:R-MMU-8868331 Reactome:R-MMU-1013873	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-8868383 Reactome:R-MMU-8868356	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-MMU-8868383 Reactome:R-MMU-8868356	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0291	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0197	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0288	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Plattner, F et al. (2014) Memory enhancement by targeting Cdk5 regulation of NR2B. Neuron 81 1070-1083 PubMed GONUTS page
↑ Luo, W et al. (2007) Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc. Natl. Acad. Sci. U.S.A. 104 9511-6 PubMed GONUTS page
↑ ^3.0 ^3.1 Fu, WY et al. (2007) Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat. Neurosci. 10 67-76 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Fu, AK et al. (2001) Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Nat. Neurosci. 4 374-81 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Samuels, BA et al. (2007) Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron 56 823-37 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Hawasli, AH et al. (2007) Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nat. Neurosci. 10 880-6 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Fu, AK et al. (2005) Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice. Proc. Natl. Acad. Sci. U.S.A. 102 15224-9 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Lee, JH et al. (2007) Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. J. Cell. Sci. 120 2259-71 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Sasaki, Y et al. (2002) Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron 35 907-20 PubMed GONUTS page
↑ Benavides, DR et al. (2007) Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability. J. Neurosci. 27 12967-76 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Lilja, L et al. (2004) Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis. J. Biol. Chem. 279 29534-41 PubMed GONUTS page
↑ ^13.0 ^13.1 Cicero, S & Herrup, K (2005) Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation. J. Neurosci. 25 9658-68 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Fu, AK et al. (2004) Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity. Proc. Natl. Acad. Sci. U.S.A. 101 6728-33 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Chergui, K et al. (2004) Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum. Proc. Natl. Acad. Sci. U.S.A. 101 2191-6 PubMed GONUTS page
↑ ^16.0 ^16.1 Remedios, R et al. (2007) A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. Nat. Neurosci. 10 1141-50 PubMed GONUTS page
↑ Takano, T et al. (2012) LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner. J. Neurosci. 32 6587-99 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Eiden, LE et al. (1987) A nomenclature proposal for the chromogranin/secretogranin proteins. Neuroscience 21 1019-21 PubMed GONUTS page
↑ ^19.0 ^19.1 Xie, Z et al. (2003) Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. Cell 114 469-82 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Li, T et al. (2007) Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. J. Biol. Chem. 282 6619-28 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 Gao, C et al. (2002) CDK5 regulates cell adhesion and migration in corneal epithelial cells. Mol. Cancer Res. 1 12-24 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Hirota, Y et al. (2007) Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone. J. Neurosci. 27 12829-38 PubMed GONUTS page
↑ Gilmore, EC et al. (1998) Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex. J. Neurosci. 18 6370-7 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Ohshima, T et al. (1996) Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc. Natl. Acad. Sci. U.S.A. 93 11173-8 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 Ko, J et al. (2001) p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J. Neurosci. 21 6758-71 PubMed GONUTS page
↑ ^26.0 ^26.1 Ohshima, T et al. (1999) Migration defects of cdk5(-/-) neurons in the developing cerebellum is cell autonomous. J. Neurosci. 19 6017-26 PubMed GONUTS page
↑ ^27.0 ^27.1 Ohshima, T et al. (2001) Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. Proc. Natl. Acad. Sci. U.S.A. 98 2764-9 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 Pareek, TK et al. (2007) Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc. Natl. Acad. Sci. U.S.A. 104 660-5 PubMed GONUTS page
↑ Fischer, A et al. (2002) Cyclin-dependent kinase 5 is required for associative learning. J. Neurosci. 22 3700-7 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Lazaro, JB et al. (1997) Cyclin dependent kinase 5, cdk5, is a positive regulator of myogenesis in mouse C2 cells. J. Cell. Sci. 110 ( Pt 10) 1251-60 PubMed GONUTS page
↑ Niethammer, M et al. (2000) NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron 28 697-711 PubMed GONUTS page
↑ ^32.0 ^32.1 Zhang, Q et al. (1997) Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling. Dev. Biol. 183 222-33 PubMed GONUTS page
↑ Mori, D et al. (2007) NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol. Cell. Biol. 27 352-67 PubMed GONUTS page
↑ ^34.0 ^34.1 Li, Z et al. (2004) Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription. J. Biol. Chem. 279 54438-44 PubMed GONUTS page
↑ ^35.0 ^35.1 Lazzaro, MA et al. (1997) A novel cdc2-related protein kinase expressed in the nervous system. J. Neurochem. 69 348-64 PubMed GONUTS page
↑ Ino, H & Chiba, T (1996) Intracellular localization of cyclin-dependent kinase 5 (CDK5) in mouse neuron: CDK5 is located in both nucleus and cytoplasm. Brain Res. 732 179-85 PubMed GONUTS page
↑ Keshvara, L et al. (2002) Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling. J. Neurosci. 22 4869-77 PubMed GONUTS page
↑ Nguyen, MD et al. (2001) Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Neuron 30 135-47 PubMed GONUTS page
↑ Hirasawa, M et al. (2004) Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects. Proc. Natl. Acad. Sci. U.S.A. 101 6249-54 PubMed GONUTS page

[PMID:24607229-1] 1.0 ^1.1 ^1.2 ^1.3 Plattner, F et al. (2014) Memory enhancement by targeting Cdk5 regulation of NR2B. Neuron 81 1070-1083 PubMed GONUTS page

[PMID:17517623-2] Luo, W et al. (2007) Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc. Natl. Acad. Sci. U.S.A. 104 9511-6 PubMed GONUTS page

[PMID:17143272-3] 3.0 ^3.1 Fu, WY et al. (2007) Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat. Neurosci. 10 67-76 PubMed GONUTS page

[PMID:11276227-4] 4.0 ^4.1 ^4.2 Fu, AK et al. (2001) Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Nat. Neurosci. 4 374-81 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18054859-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Samuels, BA et al. (2007) Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron 56 823-37 PubMed GONUTS page

[PMID:17529984-7] 7.0 ^7.1 ^7.2 ^7.3 Hawasli, AH et al. (2007) Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nat. Neurosci. 10 880-6 PubMed GONUTS page

[PMID:16203963-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Fu, AK et al. (2005) Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice. Proc. Natl. Acad. Sci. U.S.A. 102 15224-9 PubMed GONUTS page

[PMID:17591690-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Lee, JH et al. (2007) Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. J. Cell. Sci. 120 2259-71 PubMed GONUTS page

[PMID:12372285-10] 10.0 ^10.1 ^10.2 Sasaki, Y et al. (2002) Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron 35 907-20 PubMed GONUTS page

[PMID:18032670-11] Benavides, DR et al. (2007) Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability. J. Neurosci. 27 12967-76 PubMed GONUTS page

[PMID:15123626-12] 12.0 ^12.1 ^12.2 Lilja, L et al. (2004) Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis. J. Biol. Chem. 279 29534-41 PubMed GONUTS page

[PMID:16237170-13] 13.0 ^13.1 Cicero, S & Herrup, K (2005) Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation. J. Neurosci. 25 9658-68 PubMed GONUTS page

[PMID:15096606-14] 14.0 ^14.1 ^14.2 Fu, AK et al. (2004) Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity. Proc. Natl. Acad. Sci. U.S.A. 101 6728-33 PubMed GONUTS page

[PMID:14769920-15] 15.0 ^15.1 ^15.2 ^15.3 Chergui, K et al. (2004) Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum. Proc. Natl. Acad. Sci. U.S.A. 101 2191-6 PubMed GONUTS page

[PMID:17694053-16] 16.0 ^16.1 Remedios, R et al. (2007) A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. Nat. Neurosci. 10 1141-50 PubMed GONUTS page

[PMID:22573681-17] Takano, T et al. (2012) LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner. J. Neurosci. 32 6587-99 PubMed GONUTS page

[PMID:3627430-18] 18.0 ^18.1 ^18.2 Eiden, LE et al. (1987) A nomenclature proposal for the chromogranin/secretogranin proteins. Neuroscience 21 1019-21 PubMed GONUTS page

[PMID:12941275-19] 19.0 ^19.1 Xie, Z et al. (2003) Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. Cell 114 469-82 PubMed GONUTS page

[PMID:17202132-20] 20.0 ^20.1 ^20.2 Li, T et al. (2007) Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. J. Biol. Chem. 282 6619-28 PubMed GONUTS page

[PMID:12496365-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 Gao, C et al. (2002) CDK5 regulates cell adhesion and migration in corneal epithelial cells. Mol. Cancer Res. 1 12-24 PubMed GONUTS page

[PMID:18032654-22] 22.0 ^22.1 ^22.2 Hirota, Y et al. (2007) Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone. J. Neurosci. 27 12829-38 PubMed GONUTS page

[PMID:9698328-23] Gilmore, EC et al. (1998) Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex. J. Neurosci. 18 6370-7 PubMed GONUTS page

[PMID:8855328-24] 24.0 ^24.1 ^24.2 Ohshima, T et al. (1996) Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc. Natl. Acad. Sci. U.S.A. 93 11173-8 PubMed GONUTS page

[PMID:11517264-25] 25.0 ^25.1 ^25.2 ^25.3 Ko, J et al. (2001) p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J. Neurosci. 21 6758-71 PubMed GONUTS page

[PMID:10407039-26] 26.0 ^26.1 Ohshima, T et al. (1999) Migration defects of cdk5(-/-) neurons in the developing cerebellum is cell autonomous. J. Neurosci. 19 6017-26 PubMed GONUTS page

[PMID:11226314-27] 27.0 ^27.1 Ohshima, T et al. (2001) Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. Proc. Natl. Acad. Sci. U.S.A. 98 2764-9 PubMed GONUTS page

[PMID:17194758-28] 28.0 ^28.1 ^28.2 Pareek, TK et al. (2007) Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc. Natl. Acad. Sci. U.S.A. 104 660-5 PubMed GONUTS page

[PMID:11978846-29] Fischer, A et al. (2002) Cyclin-dependent kinase 5 is required for associative learning. J. Neurosci. 22 3700-7 PubMed GONUTS page

[PMID:9191048-30] 30.0 ^30.1 ^30.2 Lazaro, JB et al. (1997) Cyclin dependent kinase 5, cdk5, is a positive regulator of myogenesis in mouse C2 cells. J. Cell. Sci. 110 ( Pt 10) 1251-60 PubMed GONUTS page

[PMID:11163260-31] Niethammer, M et al. (2000) NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron 28 697-711 PubMed GONUTS page

[PMID:9126296-32] 32.0 ^32.1 Zhang, Q et al. (1997) Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling. Dev. Biol. 183 222-33 PubMed GONUTS page

[PMID:17060449-33] Mori, D et al. (2007) NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol. Cell. Biol. 27 352-67 PubMed GONUTS page

[PMID:15489224-34] 34.0 ^34.1 Li, Z et al. (2004) Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription. J. Biol. Chem. 279 54438-44 PubMed GONUTS page

[PMID:9202329-35] 35.0 ^35.1 Lazzaro, MA et al. (1997) A novel cdc2-related protein kinase expressed in the nervous system. J. Neurochem. 69 348-64 PubMed GONUTS page

[PMID:8891282-36] Ino, H & Chiba, T (1996) Intracellular localization of cyclin-dependent kinase 5 (CDK5) in mouse neuron: CDK5 is located in both nucleus and cytoplasm. Brain Res. 732 179-85 PubMed GONUTS page

[PMID:12077184-37] Keshvara, L et al. (2002) Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling. J. Neurosci. 22 4869-77 PubMed GONUTS page

[PMID:11343650-38] Nguyen, MD et al. (2001) Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Neuron 30 135-47 PubMed GONUTS page

[PMID:15067135-39] Hirasawa, M et al. (2004) Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects. Proc. Natl. Acad. Sci. U.S.A. 101 6249-54 PubMed GONUTS page

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MOUSE:CDK5

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