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MOUSE:CASPE

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Casp14
Protein Name(s) Caspase-14

CASP-14 Mini-ICE MICE Caspase-14 subunit p17, mature form Caspase-14 subunit p10, mature form Caspase-14 subunit p20, intermediate form Caspase-14 subunit p8, intermediate form

External Links
UniProt O89094
EMBL AF092997
AJ007750
CCDS CCDS23969.1
RefSeq NP_033939.1
XP_006513222.1
XP_006513223.1
UniGene Mm.20940
ProteinModelPortal O89094
SMR O89094
STRING 10090.ENSMUSP00000005488
MEROPS C14.018
PaxDb O89094
PRIDE O89094
Ensembl ENSMUST00000005488
GeneID 12365
KEGG mmu:12365
UCSC uc007fyd.2
CTD 23581
MGI MGI:1335092
eggNOG KOG3573
ENOG410ZQIE
HOGENOM HOG000231878
HOVERGEN HBG050804
InParanoid O89094
KO K04401
OMA QEERYDM
OrthoDB EOG7VQJDT
PhylomeDB O89094
TreeFam TF102023
NextBio 281044
PRO PR:O89094
Proteomes UP000000589
Bgee O89094
CleanEx MM_CASP14
ExpressionAtlas O89094
Genevisible O89094
GO GO:0005737
GO:0070062
GO:0045095
GO:0005634
GO:0097153
GO:0008233
GO:0030154
Gene3D 3.40.50.1460
InterPro IPR033174
IPR029030
IPR033139
IPR002138
IPR001309
IPR015917
PANTHER PTHR10454:SF131
PRINTS PR00376
SMART SM00115
SUPFAM SSF52129
PROSITE PS01122
PS50207
PS50208

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0097153

cysteine-type endopeptidase activity involved in apoptotic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0019972
MGI:MGI:107739
MGI:MGI:109383
MGI:MGI:1261423
MGI:MGI:97295
PANTHER:PTN000047947
UniProtKB:P42574
UniProtKB:Q14790

F

Seeded From UniProt

complete

involved_in

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000048016
UniProtKB:P55211

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010501
FB:FBgn0020381
FB:FBgn0026404
FB:FBgn0028381
FB:FBgn0033659
MGI:MGI:107739
MGI:MGI:109383
MGI:MGI:1261423
MGI:MGI:1277950
MGI:MGI:1312922
PANTHER:PTN000047947
RGD:2274
RGD:2275
RGD:61867
RGD:620945
RGD:69274
UniProtKB:O15519
UniProtKB:P42574
UniProtKB:P55210
UniProtKB:P55211
UniProtKB:Q14790
WB:WBGene00000417

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0019972
FB:FBgn0020381
FB:FBgn0026404
FB:FBgn0028381
FB:FBgn0033051
MGI:MGI:107739
MGI:MGI:1261423
MGI:MGI:1336166
MGI:MGI:97295
PANTHER:PTN000047947
RGD:2274
RGD:2275
RGD:61867
RGD:620945
RGD:70967
UniProtKB:O15519
UniProtKB:P31944
UniProtKB:Q95ND5
UniProtKB:Q9ULZ3
WB:WBGene00000417

C

Seeded From UniProt

complete

part_of

GO:0045095

keratin filament

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1311781

C

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

PMID:12819136[2]

ECO:0000245

automatically integrated combinatorial evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006508

proteolysis

PMID:12819136[2]

ECO:0000245

automatically integrated combinatorial evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P31944

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P31944

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P31944

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P31944

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1311781

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2CIS9
ensembl:ENSP00000393417

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2CIS9
ensembl:ENSP00000393417

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2CIS9
ensembl:ENSP00000393417

C

Seeded From UniProt

complete

part_of

GO:0045095

keratin filament

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZZ65
ensembl:ENSRNOP00000009643

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZZ65
ensembl:ENSRNOP00000009643

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P31944
ensembl:ENSP00000393417

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P31944
ensembl:ENSP00000393417

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P31944
ensembl:ENSP00000393417

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P31944
ensembl:ENSP00000393417

C

Seeded From UniProt

complete

enables

GO:0004197

cysteine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001309
InterPro:IPR002138
InterPro:IPR002398
InterPro:IPR033174

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001309
InterPro:IPR002138
InterPro:IPR002398

P

Seeded From UniProt

complete

enables

GO:0008234

cysteine-type peptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015917

F

Seeded From UniProt

complete

involved_in

GO:0070268

cornification

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033174

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

PMID:9823333[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0008234

cysteine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0788

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. 2.0 2.1 Reed, JC et al. (2003) Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res. 13 1376-88 PubMed GONUTS page
  3. Ahmad, M et al. (1998) Identification and characterization of murine caspase-14, a new member of the caspase family. Cancer Res. 58 5201-5 PubMed GONUTS page