GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

MOUSE:CADM1

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Cadm1 (ECO:0000312 with MGI:MGI:1889272)
Protein Name(s) Cell adhesion molecule 1

Immunoglobulin superfamily member 4 IgSF4 Nectin-like protein 2 NECL-2 Spermatogenic immunoglobulin superfamily SgIgSF Synaptic cell adhesion molecule SynCAM Tumor suppressor in lung cancer 1 TSLC-1

External Links
UniProt Q8R5M8
EMBL AF434663
AF539424
AB021964
AB021965
AB064265
AY351388
AF061260
AB092414
AB183399
AB183400
AB183401
AB183402
CCDS CCDS23147.1
CCDS23148.1
CCDS23149.1
CCDS23150.1
RefSeq NP_001020771.1
NP_061240.3
NP_997558.2
NP_997559.1
UniGene Mm.234832
ProteinModelPortal Q8R5M8
SMR Q8R5M8
IntAct Q8R5M8
MINT MINT-4131381
STRING 10090.ENSMUSP00000083073
MEROPS I43.001
PhosphoSite Q8R5M8
MaxQB Q8R5M8
PaxDb Q8R5M8
PRIDE Q8R5M8
Ensembl ENSMUST00000034581
ENSMUST00000085909
ENSMUST00000114547
ENSMUST00000114548
GeneID 54725
KEGG mmu:54725
UCSC uc009phn.1
uc009pho.1
uc009phq.1
uc009phr.1
uc009phs.1
CTD 23705
MGI MGI:1889272
eggNOG NOG69486
GeneTree ENSGT00770000120518
HOVERGEN HBG057086
InParanoid Q8R5M8
KO K06781
OrthoDB EOG7PVWPD
PhylomeDB Q8R5M8
TreeFam TF334317
Reactome REACT_230395
REACT_245004
ChiTaRS Cadm1
NextBio 311582
PRO PR:Q8R5M8
Proteomes UP000000589
Bgee Q8R5M8
CleanEx MM_CADM1
ExpressionAtlas Q8R5M8
Genevestigator Q8R5M8
GO GO:0030424
GO:0016323
GO:0005911
GO:0030425
GO:0070062
GO:0016021
GO:0005886
GO:0045202
GO:0008021
GO:0030165
GO:0042803
GO:0005102
GO:0006915
GO:0060348
GO:0007420
GO:0016338
GO:0007155
GO:0030154
GO:0008037
GO:0051606
GO:0007157
GO:0007156
GO:0002376
GO:0001889
GO:0050715
GO:0045954
GO:0007283
GO:0042271
GO:0007416
GO:0009826
Gene3D 2.60.40.10
InterPro IPR013162
IPR007110
IPR013783
IPR003599
IPR003598
IPR013106
IPR003585
Pfam PF08205
PF07686
SMART SM00294
SM00409
SM00408
PROSITE PS50835

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0022414

reproductive process

PMID:16611999[1]

ECO:0000315

P

Figures 2, 3, 4, 5, and 6.

complete
CACAO 3449

involved_in

GO:0051606

detection of stimulus

PMID:15811952[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045954

positive regulation of natural killer cell mediated cytotoxicity

PMID:15811952[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:12826663[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042271

susceptibility to natural killer cell mediated cytotoxicity

PMID:15811952[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030165

PDZ domain binding

PMID:12826663[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9JLB0

F

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

PMID:12826663[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008037

cell recognition

PMID:15811952[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007157

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

PMID:12826663[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

PMID:12826663[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005911

cell-cell junction

PMID:12826663[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:15811952[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q149L7

F

Seeded From UniProt

complete

involved_in

GO:0099560

synaptic membrane adhesion

PMID:18003830[4]

ECO:0006064

cell-free assay evidence used in manual assertion

P

occurs_in:(UBERON:0001890)

Seeded From UniProt

complete

involved_in

GO:0099560

synaptic membrane adhesion

PMID:18003830[4]

ECO:0006042

cell fractionation evidence used in manual assertion

P

occurs_in:(UBERON:0001890)

Seeded From UniProt

complete

involved_in

GO:0099560

synaptic membrane adhesion

PMID:18003830[4]

ECO:0005589

confocal microscopy evidence used in manual assertion

P

occurs_in:(UBERON:0001890)

Seeded From UniProt

complete

involved_in

GO:0099560

synaptic membrane adhesion

PMID:18003830[4]

ECO:0000279

western blot evidence used in manual assertion

P

occurs_in:(UBERON:0001890)

Seeded From UniProt

complete

part_of

GO:0099056

integral component of presynaptic membrane

PMID:26687224[5]

ECO:0006003

electron microscopy evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0099055

integral component of postsynaptic membrane

PMID:26687224[5]

ECO:0006004

super-resolution microscopy evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0099055

integral component of postsynaptic membrane

PMID:26687224[5]

ECO:0006004

super-resolution microscopy evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0099055

integral component of postsynaptic membrane

PMID:26687224[5]

ECO:0006003

electron microscopy evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0099055

integral component of postsynaptic membrane

PMID:26687224[5]

ECO:0006003

electron microscopy evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0099054

presynapse assembly

PMID:12202822[6]

ECO:0006063

over expression analysis evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0099054

presynapse assembly

PMID:12202822[6]

ECO:0006039

genetically encoded fluorescent electrophysiology assay evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0099054

presynapse assembly

PMID:12202822[6]

ECO:0005589

confocal microscopy evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:12202822[6]

ECO:0006063

over expression analysis evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:12202822[6]

ECO:0006039

genetically encoded fluorescent electrophysiology assay evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:12202822[6]

ECO:0005589

confocal microscopy evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0098942

retrograde trans-synaptic signaling by trans-synaptic protein complex

PMID:23209303[7]

ECO:0006063

over expression analysis evidence used in manual assertion

P

occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0098942

retrograde trans-synaptic signaling by trans-synaptic protein complex

PMID:23209303[7]

ECO:0005589

confocal microscopy evidence used in manual assertion

P

occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0098942

retrograde trans-synaptic signaling by trans-synaptic protein complex

PMID:23209303[7]

ECO:0001225

knockout evidence used in manual assertion

P

occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0098880

maintenance of postsynaptic specialization structure

PMID:21145003[8]

ECO:0006003

electron microscopy evidence used in manual assertion

P

occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0098880

maintenance of postsynaptic specialization structure

PMID:21145003[8]

ECO:0006003

electron microscopy evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0098880

maintenance of postsynaptic specialization structure

PMID:21145003[8]

ECO:0005589

confocal microscopy evidence used in manual assertion

P

occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0098880

maintenance of postsynaptic specialization structure

PMID:21145003[8]

ECO:0005589

confocal microscopy evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0098880

maintenance of postsynaptic specialization structure

PMID:21145003[8]

ECO:0001225

knockout evidence used in manual assertion

P

occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0098880

maintenance of postsynaptic specialization structure

PMID:21145003[8]

ECO:0001225

knockout evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0098685

Schaffer collateral - CA1 synapse

PMID:26687224[5]

ECO:0006004

super-resolution microscopy evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0098685

Schaffer collateral - CA1 synapse

PMID:26687224[5]

ECO:0006003

electron microscopy evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0098685

Schaffer collateral - CA1 synapse

PMID:21145003[8]

ECO:0006003

electron microscopy evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0098685

Schaffer collateral - CA1 synapse

PMID:21145003[8]

ECO:0005589

confocal microscopy evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0098685

Schaffer collateral - CA1 synapse

PMID:21145003[8]

ECO:0001225

knockout evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007416

synapse assembly

PMID:21145003[8]

ECO:0006003

electron microscopy evidence used in manual assertion

P

occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0007416

synapse assembly

PMID:21145003[8]

ECO:0006003

electron microscopy evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007416

synapse assembly

PMID:21145003[8]

ECO:0005589

confocal microscopy evidence used in manual assertion

P

occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0007416

synapse assembly

PMID:21145003[8]

ECO:0005589

confocal microscopy evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007416

synapse assembly

PMID:21145003[8]

ECO:0001225

knockout evidence used in manual assertion

P

occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0007416

synapse assembly

PMID:21145003[8]

ECO:0001225

knockout evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042271

susceptibility to natural killer cell mediated cytotoxicity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1889272
PANTHER:PTN000589344
UniProtKB:Q9BY67

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060348

bone development

PMID:22876197[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051606

detection of stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9BY67

P

Seeded From UniProt

complete

enables

GO:0050839

cell adhesion molecule binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1310999

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050715

positive regulation of cytokine secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9BY67

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045954

positive regulation of natural killer cell mediated cytotoxicity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9BY67

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:12202822[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1310999

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042271

susceptibility to natural killer cell mediated cytotoxicity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9BY67

P

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

PMID:15707673[11]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17544)
  • part_of:(CL:0000117)

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:15707673[11]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17544)
  • part_of:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016338

calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

PMID:12202822[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0014069

postsynaptic density

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1310999

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009826

unidimensional cell growth

PMID:18055550[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3769418

P

  • occurs_in:(EMAPA:17972)
  • occurs_in:(CL:0000019)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008037

cell recognition

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9BY67

P

Seeded From UniProt

complete

part_of

GO:0008021

synaptic vesicle

PMID:12202822[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007416

synapse assembly

PMID:12202822[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007155

cell adhesion

PMID:12202822[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005911

cell-cell junction

PMID:22512338[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15707673[11]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17544)
  • part_of:(CL:0000117)

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9BY67

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1310999

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9BY67

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001889

liver development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1310999

P

Seeded From UniProt

complete

part_of

GO:0070852

cell body fiber

PMID:21482734[14]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000540)

Seeded From UniProt

complete

part_of

GO:0070852

cell body fiber

PMID:21482734[14]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000540)

Seeded From UniProt

complete

part_of

GO:0043196

varicosity

PMID:21482734[14]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000540)

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0770
UniProtKB-SubCell:SL-0258

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0744

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. van der Weyden, L et al. (2006) Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis. Mol. Cell. Biol. 26 3595-609 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Boles, KS et al. (2005) The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. Blood 106 779-86 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Shingai, T et al. (2003) Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. J. Biol. Chem. 278 35421-7 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Fogel, AI et al. (2007) SynCAMs organize synapses through heterophilic adhesion. J. Neurosci. 27 12516-30 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Perez de Arce, K et al. (2015) Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains. Neuron 88 1165-1172 PubMed GONUTS page
  6. 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 Biederer, T et al. (2002) SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 297 1525-31 PubMed GONUTS page
  7. 7.0 7.1 7.2 Cheadle, L & Biederer, T (2012) The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization. J. Cell Biol. 199 985-1001 PubMed GONUTS page
  8. 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 8.13 8.14 Robbins, EM et al. (2010) SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning. Neuron 68 894-906 PubMed GONUTS page
  9. Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  10. Bassett, JH et al. (2012) Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. PLoS Genet. 8 e1002858 PubMed GONUTS page
  11. 11.0 11.1 11.2 Fujita, E et al. (2005) Distribution of RA175/TSLC1/SynCAM, a member of the immunoglobulin superfamily, in the developing nervous system. Brain Res. Dev. Brain Res. 154 199-209 PubMed GONUTS page
  12. Fujita, E et al. (2007) Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice. Am. J. Pathol. 171 1800-10 PubMed GONUTS page
  13. Ishiuchi, T & Takeichi, M (2012) Nectins localize Willin to cell-cell junctions. Genes Cells 17 387-97 PubMed GONUTS page
  14. 14.0 14.1 14.2 Hagiyama, M et al. (2011) Enhanced nerve-mast cell interaction by a neuronal short isoform of cell adhesion molecule-1. J. Immunol. 186 5983-92 PubMed GONUTS page