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MOUSE:BIR1B

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Naip2 (synonyms: Birc1b, Naip-rs6)
Protein Name(s) Baculoviral IAP repeat-containing protein 1b

Neuronal apoptosis inhibitory protein 2

External Links
UniProt Q9QUK4
EMBL AF135489
AF135490
AF102871
AF131205
CT030167
U66329
CCDS CCDS26726.1
PIR T42628
RefSeq NP_001119654.1
NP_035002.2
UniGene Mm.89961
ProteinModelPortal Q9QUK4
SMR Q9QUK4
DIP DIP-59160N
STRING 10090.ENSMUSP00000070827
iPTMnet Q9QUK4
PhosphoSite Q9QUK4
MaxQB Q9QUK4
PaxDb Q9QUK4
PRIDE Q9QUK4
Ensembl ENSMUST00000067975
ENSMUST00000117913
GeneID 17948
KEGG mmu:17948
UCSC uc007rqj.2
CTD 17948
MGI MGI:1298226
eggNOG KOG1101
ENOG410YPNM
GeneTree ENSGT00500000044782
HOGENOM HOG000236326
HOVERGEN HBG050689
InParanoid Q9QUK4
KO K12807
OMA DISRHIP
OrthoDB EOG73BVBV
TreeFam TF105356
NextBio 292855
PRO PR:Q9QUK4
Proteomes UP000000589
Bgee Q9QUK4
CleanEx MM_NAIP2
ExpressionAtlas Q9QUK4
Genevisible Q9QUK4
GO GO:0005737
GO:0070062
GO:0072557
GO:0005634
GO:0005524
GO:0043027
GO:0046872
GO:0004842
GO:0071391
GO:0042742
GO:0016045
GO:0006954
GO:1990001
GO:0045087
GO:0043066
GO:0043154
GO:0016567
GO:0070269
GO:0009966
Gene3D 1.10.1170.10
3.80.10.10
InterPro IPR001370
IPR032675
IPR007111
IPR027417
Pfam PF00653
SMART SM00238
SUPFAM SSF52540
PROSITE PS01282
PS50143
PS50837

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0072557

IPAF inflammasome complex

PMID:21874021[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070269

pyroptosis

PMID:21874021[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

PMID:21874021[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016045

detection of bacterium

PMID:21874021[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:21874021[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q13075

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071391

cellular response to estrogen stimulus

PMID:17901126[2]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:29915)
  • occurs_in:(CL:0000066)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13075

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q13075

F

Seeded From UniProt

complete

enables

GO:0043027

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028789

F

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028789

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0395

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Kofoed, EM & Vance, RE (2011) Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 477 592-5 PubMed GONUTS page
  2. Yin, Y et al. (2008) Estrogen suppresses uterine epithelial apoptosis by inducing birc1 expression. Mol. Endocrinol. 22 113-25 PubMed GONUTS page