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MOUSE:BAZ2A

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Baz2a (synonyms: Kiaa0314, Tip5)
Protein Name(s) Bromodomain adjacent to zinc finger domain protein 2A

Transcription termination factor I-interacting protein 5 TTF-I-interacting protein 5 Tip5

External Links
UniProt Q91YE5
EMBL AK155523
AJ309544
AK122243
UniGene Mm.252213
ProteinModelPortal Q91YE5
SMR Q91YE5
PhosphoSite Q91YE5
MaxQB Q91YE5
PaxDb Q91YE5
PRIDE Q91YE5
MGI MGI:2151152
eggNOG COG5076
HOGENOM HOG000169644
HOVERGEN HBG107494
InParanoid Q91YE5
PhylomeDB Q91YE5
Reactome REACT_200667
REACT_214440
ChiTaRS Baz2a
PRO PR:Q91YE5
Proteomes UP000000589
CleanEx MM_BAZ2A
Genevestigator Q91YE5
GO GO:0005677
GO:0005730
GO:0033553
GO:0003677
GO:0070577
GO:0003723
GO:0008270
GO:0006338
GO:0000183
GO:0006306
GO:0070869
GO:0016575
GO:0051567
GO:0070933
GO:0034770
GO:0006351
Gene3D 1.20.920.10
3.30.40.10
3.30.890.10
InterPro IPR017956
IPR001487
IPR018359
IPR004022
IPR018500
IPR018501
IPR016177
IPR001739
IPR028940
IPR028942
IPR028935
IPR011011
IPR001965
IPR019787
IPR013083
PANTHER PTHR22880:SF141
Pfam PF00439
PF02791
PF01429
PF00628
PF15612
PF15614
PRINTS PR00503
SMART SM00384
SM00297
SM00571
SM00391
SM00249
SUPFAM SSF47370
SSF54171
SSF57903
PROSITE PS00633
PS50014
PS50827
PS50982
PS50016

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016479

negative regulation of transcription from RNA polymerase I promoter

PMID:12368916[1]

ECO:0000315

P

Figure 1a. Increase in Tip5 increases proportion of heterochromatin,preventing Pol1 transcription.

complete
CACAO 3895

involved_in

GO:0016479

negative regulation of transcription by RNA polymerase I

PMID:12368916[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070577

lysine-acetylated histone binding

PMID:16085498[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0070577

lysine-acetylated histone binding

PMID:19578370[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0033553

rDNA heterochromatin

PMID:12198165[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0033553

rDNA heterochromatin

PMID:19578370[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016575

histone deacetylation

PMID:12198165[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006306

DNA methylation

PMID:16085498[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006306

DNA methylation

PMID:19578370[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:18600236[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:16085498[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:19578370[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005677

chromatin silencing complex

PMID:16085498[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005677

chromatin silencing complex

PMID:19578370[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:18600236[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:19578370[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000183

chromatin silencing at rDNA

PMID:12198165[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000183

chromatin silencing at rDNA

PMID:16085498[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000183

chromatin silencing at rDNA

PMID:19578370[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070933

histone H4 deacetylation

PMID:16678107[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070869

heterochromatin assembly involved in chromatin silencing

PMID:20168299[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070869

heterochromatin assembly involved in chromatin silencing

PMID:16678107[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051567

histone H3-K9 methylation

PMID:16678107[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042393

histone binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UIF9

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034770

histone H4-K20 methylation

PMID:16678107[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UIF9

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006338

chromatin remodeling

PMID:11532953[8]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1935129

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UIF9

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:16678107[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:11532953[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:16678107[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:11532953[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001164

RNA polymerase I CORE element sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UIF9

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000183

chromatin silencing at rDNA

PMID:20168299[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000183

chromatin silencing at rDNA

PMID:16678107[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001188

RNA polymerase I preinitiation complex assembly

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0001164

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001739
InterPro:IPR016177
InterPro:IPR017956

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001739

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-MMU-573383
Reactome:R-MMU-573376
Reactome:R-MMU-573336

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Santoro, R et al. (2002) The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Nat. Genet. 32 393-6 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Zhou, Y & Grummt, I (2005) The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing. Curr. Biol. 15 1434-8 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Zhou, Y et al. (2009) Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing. Nat. Cell Biol. 11 1010-6 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Zhou, Y et al. (2002) The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription. EMBO J. 21 4632-40 PubMed GONUTS page
  5. ↑ 5.0 5.1 Mayer, C et al. (2008) The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus. EMBO Rep. 9 774-80 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Mayer, C et al. (2006) Intergenic transcripts regulate the epigenetic state of rRNA genes. Mol. Cell 22 351-61 PubMed GONUTS page
  7. ↑ 7.0 7.1 Guetg, C et al. (2010) The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats. EMBO J. 29 2135-46 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Strohner, R et al. (2001) NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines. EMBO J. 20 4892-900 PubMed GONUTS page
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